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Astronauts face numerous health challenges during long-duration space missions, including diminished immunity, bone loss and increased risk of radiation-induced carcinogenesis. Changes in the intestinal flora of astronauts may contribute to these problems. Soy-based fermented food products could provide a nutritional strategy to help alleviate these challenges by incorporating beneficial lactic acid bacteria, while reaping the benefits of soy isoflavones. We carried out strain selection for the development of soy ferments, selecting strains of lactic acid bacteria showing the most effective growth and fermentation ability in soy milk (Streptococcus thermophilus ST5, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052). Immunomodulatory bioactivity of selected ferments was assessed using an in vitro challenge system with human intestinal epithelial and macrophage cell lines, and selected ferments show the ability to down-regulate production of the pro-inflammatory cytokine interleukin-8 following challenge with tumour necrosis factor-alpha. The impact of fermentation on vitamin B1 and B6 levels and on isoflavone biotransformation to agluconic forms was also assessed, with strain variation-dependent biotransformation ability detected. Overall this suggests that probiotic bacteria can be successfully utilized to develop soy-based fermented products targeted against health problems associated with long-term space travel.  相似文献   
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Green  J.L.  Benson  R.F.  Fung  S.F.  Taylor  W.W.L.  Boardsen  S.A.  Reinisch  B.W.  Haines  D.M.  Bibl  K.  Cheney  G.  Galkin  I.A.  Huang  X.  Myers  S.H.  Sales  G.S.  Bougeret  J.-L.  Manning  R.  Meyer-Vernet  N.  Moncuquet  M.  Carpenter  D.L.  Gallagher  D.L.  Reiff  P.H. 《Space Science Reviews》2000,91(1-2):361-389
The Radio Plasma Imager (RPI) will be the first-of-its kind instrument designed to use radio wave sounding techniques to perform repetitive remote sensing measurements of electron number density (N e) structures and the dynamics of the magnetosphere and plasmasphere. RPI will fly on the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) mission to be launched early in the year 2000. The design of the RPI is based on recent advances in radio transmitter and receiver design and modern digital processing techniques perfected for ground-based ionospheric sounding over the last two decades. Free-space electromagnetic waves transmitted by the RPI located in the low-density magnetospheric cavity will be reflected at distant plasma cutoffs. The location and characteristics of the plasma at those remote reflection points can then be derived from measurements of the echo amplitude, phase, delay time, frequency, polarization, Doppler shift, and echo direction. The 500 m tip-to-tip X and Y (spin plane) antennas and 20 m Z axis antenna on RPI will be used to measures echoes coming from distances of several R E. RPI will operate at frequencies between 3 kHz to 3 MHz and will provide quantitative N e values from 10–1 to 105 cm–3. Ray tracing calculations, combined with specific radio imager instrument characteristics, enables simulations of RPI measurements. These simulations have been performed throughout an IMAGE orbit and under different model magnetospheric conditions. They dramatically show that radio sounding can be used quite successfully to measure a wealth of magnetospheric phenomena such as magnetopause boundary motions and plasmapause dynamics. The radio imaging technique will provide a truly exciting opportunity to study global magnetospheric dynamics in a way that was never before possible.  相似文献   
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The Radio Plasma Imager investigation on the IMAGE spacecraft   总被引:1,自引:0,他引:1  
Reinisch  B.W.  Haines  D.M.  Bibl  K.  Cheney  G.  Galkin  I.A.  Huang  X.  Myers  S.H.  Sales  G.S.  Benson  R.F.  Fung  S.F.  Green  J.L.  Boardsen  S.  Taylor  W.W.L.  Bougeret  J.-L.  Manning  R.  Meyer-Vernet  N.  Moncuquet  M.  Carpenter  D.L.  Gallagher  D.L.  Reiff  P. 《Space Science Reviews》2000,91(1-2):319-359
Radio plasma imaging uses total reflection of electromagnetic waves from plasmas whose plasma frequencies equal the radio sounding frequency and whose electron density gradients are parallel to the wave normals. The Radio Plasma Imager (RPI) has two orthogonal 500-m long dipole antennas in the spin plane for near omni-directional transmission. The third antenna is a 20-m dipole along the spin axis. Echoes from the magnetopause, plasmasphere and cusp will be received with the three orthogonal antennas, allowing the determination of their angle-of-arrival. Thus it will be possible to create image fragments of the reflecting density structures. The instrument can execute a large variety of programmable measuring options at frequencies between 3 kHz and 3 MHz. Tuning of the transmit antennas provides optimum power transfer from the 10 W transmitter to the antennas. The instrument can operate in three active sounding modes: (1) remote sounding to probe magnetospheric boundaries, (2) local (relaxation) sounding to probe the local plasma frequency and scalar magnetic field, and (3) whistler stimulation sounding. In addition, there is a passive mode to record natural emissions, and to determine the local electron density, the scalar magnetic field, and temperature by using a thermal noise spectroscopy technique.  相似文献   
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The French mobile station for recording geophysical data has been put in operation at Husafell, Iceland (64°5N, 20°8W) between the 10th of July and the 22nd of September, 1977. This place was more or less conjugated with GEOS when this satellite was near its apogee. The equipments installed in the station for recording VLF and ULF phenomena have characteristics (band-pass, sampling rates) which are identical to the similar equipments installed onboard GEOS. Intercomparison between signals recorded at both points are therefore easy. We present here the results which were obtained in the VLF range.In many occasions, VLF emissions (mainly hiss) do present identical variations in amplitude, with a very abrupt (<1 mn) and very large (>20 dB) decrease in amplitude. Because of their simultaneity at both points, such abrupt variations cannot be interpreted in terms of a sudden ionospheric absorption (associated with an enhanced particle precipitation) nor in terms of a sudden crossing of detached plasma regions. In some cases, these abrupt changes in the VLF intensity are associated with the appearance and disappearance of strong ULF emissions, in the Pc-1 frequency range. Some examples of associated onboard measurements of high energy electron fluxes or cold plasma density (when available) are given, which may help understanding these VLF conjugated relationships.  相似文献   
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Requirements are rarely static, and are ever more likely to evolve as the development time of a system stretches out and its service life increases. In this paper, we discuss the evolution of requirements for the US spacesuit, the extravehicular mobility unit (EMU), as a case study to highlight the need for flexibility in system design. We explore one fundamental environmental change, using the Space Shuttle EMU aboard the International Space Station, and the resulting EMU requirement and design changes. The EMU, like other complex systems, faces considerable uncertainty during its service life. Changes in the technical, political, or economic environment cause changes in requirements, which in turn necessitate design modifications or upgrades. We make the case that flexibility is a key attribute that needs to be embedded in the design of long-lived, complex systems to enable them to efficiently meet the inevitability of changing requirements after they have been fielded.  相似文献   
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The paper deals with the mission analysis and conceptual design of an interplanetary 6U CubeSats system to be implemented in the L1 Earth–Sun Lagrangian Point mission for solar observation and in-situ space weather measurements.  相似文献   
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At the beginning of the GEOS lifetime, some attempts have been made for taking advantage of the passes over Alaska. GEOS was then commanded in a fixed mode and the corresponding telemetry data were recorded at the NASA stations. For two passes over Jim Creek (48°2N–121°9W) where a powerful VLF transmitter (f 0 = 18.6 kHz) is located, GEOS was put in a specific mode in order to study the magnetospheric electromagnetic field in the vicinity of f 0. The results of one pass (June 11, from 0755 UT) are presented here.During this pass, a strong enhancement of all the e.m. components at f 0 has been observed for a specific period of time, when GEOS was very near to the exact conjugacy with NKL. The distance, as measured on the ground, over which the signal was above -6 dB from the maximum is of the order of 800 km. During the corresponding period of time (0740–0750 UT), the satellite altitude varied between 8000 and 6000 km. The magnetospheric region where the signal is strong appears to be structured, as if there were many ducts.Preliminary results concerning the polarization characteristics of the signal are presented. In the absence of precise measurements of these characteristics, the comparison between the electric and magnetic components of the received signal is not easy to interpret. An examination of the onboard computed correlograms (in the frequency range from f 0 -0.6 kHz to f 0 +3.3 kHz) shows that, for this pass, no VLF emissions were triggered by NKL, at the altitude of the satellite.  相似文献   
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The physics of using a radioastronomy receiver as an in-situ detector of plasma, and in some cases of molecules and dust grains is reviewed, and applied to ICE encounter with comet Giacobini-Zinner. In the comet's plasma tail, the receiver recorded mostly quasi-thermal plasma noise. The spectroscopy of that noise yields the density and temperature of the main (cold) electron population, and parameters of hot electrons. The absence of grain detection yields a quantitative upper limit on grain mass or flux. An additionnal diagnosis is provided by partial occultations of both the radio galactic noise and the terrestrial kilometric radiation. Implications for comparison with earth-based measurements are indicated.  相似文献   
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