Harnessing functional food strategies for the health challenges of space travel—Fermented soy for astronaut nutrition

Astronauts face numerous health challenges during long-duration space missions, including diminished immunity, bone loss and increased risk of radiation-induced carcinogenesis. Changes in the intestinal flora of astronauts may contribute to these problems. Soy-based fermented food products could provide a nutritional strategy to help alleviate these challenges by incorporating beneficial lactic acid bacteria, while reaping the benefits of soy isoflavones. We carried out strain selection for the development of soy ferments, selecting strains of lactic acid bacteria showing the most effective growth and fermentation ability in soy milk (Streptococcus thermophilus ST5, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052). Immunomodulatory bioactivity of selected ferments was assessed using an in vitro challenge system with human intestinal epithelial and macrophage cell lines, and selected ferments show the ability to down-regulate production of the pro-inflammatory cytokine interleukin-8 following challenge with tumour necrosis factor-alpha. The impact of fermentation on vitamin B1 and B6 levels and on isoflavone biotransformation to agluconic forms was also assessed, with strain variation-dependent biotransformation ability detected. Overall this suggests that probiotic bacteria can be successfully utilized to develop soy-based fermented products targeted against health problems associated with long-term space travel.     

Effects of heavy ions on inactivation and DNA double strand breaks in Deinococcus radiodurans R1.

Inactivation and double strand break (dsb) induction after heavy ion irradiation were studied in stationary phase cells of the highly radiation resistant bacterium Deinococcus radiodurans R1. There is evidence that the radiation sensitivity of this bacterium is nearly independent on energy in the range of up to 15 MeV/u for lighter ions (Ar). The responses to dsb induction for charged particles show direct relationship between increasing radiation dose and residual intact DNA.     

Radiation stability of organic matter in liquid and frozen H2O, NH3 and water-ammonia mixtures

The redox properties of irradiated liquid and frozen H₂O, NH₃ and H₂O/NH₃ mixtures at 298 K and 77 K, resp., towards some simple organic molecules have been checked by injecting carrierfree ¹¹C atoms and analyzing their chemical state by means of radiochromatography. The reactions and the stability of organic products versus radiation dose (in this study by MeV protons) depend on temperature, phase state, mobility of radicals, their concentration and reactivity. Especially dangerous are the reactive OH and O₂H radicals which oxidize organic material to inorganic CO₂. Highest stability has been found at low temperatures (solid state, reduced mobility of radicals) and for systems containing H-donors (H₂O/NH₃ mixtures), which reduce the concentration of oxidizing radicals. The fact that many bodies in space consist of H₂O-ice with NH₃ and CH₄ additives at temperatures between 10 and 150 K is promising in view of the survival of organic matter under high doses of radiation.     

VLF waves: Conjugated ground-satellite relationships

The French mobile station for recording geophysical data has been put in operation at Husafell, Iceland (64°5N, 20°8W) between the 10th of July and the 22nd of September, 1977. This place was more or less conjugated with GEOS when this satellite was near its apogee. The equipments installed in the station for recording VLF and ULF phenomena have characteristics (band-pass, sampling rates) which are identical to the similar equipments installed onboard GEOS. Intercomparison between signals recorded at both points are therefore easy. We present here the results which were obtained in the VLF range.In many occasions, VLF emissions (mainly hiss) do present identical variations in amplitude, with a very abrupt (<1 mn) and very large (>20 dB) decrease in amplitude. Because of their simultaneity at both points, such abrupt variations cannot be interpreted in terms of a sudden ionospheric absorption (associated with an enhanced particle precipitation) nor in terms of a sudden crossing of detached plasma regions. In some cases, these abrupt changes in the VLF intensity are associated with the appearance and disappearance of strong ULF emissions, in the Pc-1 frequency range. Some examples of associated onboard measurements of high energy electron fluxes or cold plasma density (when available) are given, which may help understanding these VLF conjugated relationships.     

Calibration results obtained with Liulin-4 type dosimeters.

The Mobile Radiation Exposure Control System's (Liulin-4 type) main purpose is to monitor simultaneously the doses and fluxes at 4 independent places. It can also be used for personnel dosimetry. The system consists of 4 battery-operated 256-channel dosimeters-spectrometers. We describe results obtained during the calibrations of the spectrometers at the Cyclotron facilities of the University of Louvain, Belgium and of the National Institute of Radiological Sciences-STA, Chiba, Japan with protons of energies up to 70 MeV. The angular sensitivities of the devices are studied and compared with Monte-Carlo predictions. We also present the results obtained at the HIMAC accelerator with 500 MeV/u Fe ions and at the CERN high energy radiation reference fields. Records made during airplane flights are shown and compared with the predictions of the CARI-6 model.     

The extravehicular mobility unit: A review of environment, requirements, and design changes in the US spacesuit

Requirements are rarely static, and are ever more likely to evolve as the development time of a system stretches out and its service life increases. In this paper, we discuss the evolution of requirements for the US spacesuit, the extravehicular mobility unit (EMU), as a case study to highlight the need for flexibility in system design. We explore one fundamental environmental change, using the Space Shuttle EMU aboard the International Space Station, and the resulting EMU requirement and design changes. The EMU, like other complex systems, faces considerable uncertainty during its service life. Changes in the technical, political, or economic environment cause changes in requirements, which in turn necessitate design modifications or upgrades. We make the case that flexibility is a key attribute that needs to be embedded in the design of long-lived, complex systems to enable them to efficiently meet the inevitability of changing requirements after they have been fielded.     

Navigating the Bamboo Sea

Changning County, Sichuan Province- The ants are on my trail. Thinking I've lost them, I stop to rest. But a few of them have battled their way up the steep path and are catching up to me. Soon I'll be done for. In desperation, I go off trail,weaving through grass so high it blocks out the sun.