LET dependence of cell death, mutation induction and chromatin damage in human cells irradiated with accelerated carbon ions.

We investigated the LET dependence of cell death, mutation induction and chromatin break induction in human embryo (HE) cells irradiated by accelerated carbon-ion beams. The results showed that cell death, mutation induction and induction of non-rejoining chromatin breaks detected by the premature chromosome condensation (PCC) technique had the same LET dependence. Carbon ions of 110 to 124keV/micrometer were the most effective at all endpoints. However, the number of initially induced chromatin breaks was independent of LET. About 10 to 15 chromatin breaks per Gy per cell were induced in the LET range of 22 to 230 keV/micrometer. The deletion pattern of exons in the HPRT locus, analyzed by the polymerase chain reaction (PCR), was LET-specific. Almost all of the mutants induced by 124 keV/micrometer beams showed deletion of the entire gene, while all mutants induced by 230keV/micrometer carbon-ion beams showed no deletion. These results suggest that the difference in the density distribution of carbon-ion track and secondary electron with various LET is responsible for the LET dependency of biological effects.     

Telescience testbed for biomedical experiments in space morphological and physiological experiments of rat musculoskeletal system.

As the second telescience testbed experiment we were examined sophisticated processes of biomedical experiment, such as an implantation of a transmitter into the hamster's abdominal cavity, non-stressful blood sampling, large amount of blood collection, muscle extirpation and biopsy from the hamsters on February 6-8, 1990. To make clear the differences between successful results obtained by an experienced hand and by a non-experienced one, three operators were selected for three successive experimental days; an engineer who had never experienced any biological experiment, a non-biology student, who experienced on biological experiments, and a veterinary surgeon. Surgical procedures need much experiences on maneuvering and understanding of theory to shorten the elapse time. Especially for a non-experienced hand, graphic instructions were much helpful to understand and to maneuver the procedures. Continuous recordings of ECG from a operator and PIs were of an advantage to grasp an extent of the mental strain, which was compared with their reports requested after end of each experimental day. The mental strain was not related to degrees of scientific achievement, but showed faithfully difficulty of each experimental procedure. Training effects on PIs in successive experimental days were found in their instructions for the operator to let understand the procedures.     

Evaluation of Voigt algorithms for the ISS/JEM/SMILES L2 data processing system

We present a calculation of the accuracy and speed of the Voigt function of various algorithms (Armstrong (1967), Hui et al. (1978), Humlicek (1982) and improved version of Kuntz (1997) developed in this study) for making the faster and higher accuracy forward model required for the Superconducting Submillimeter-Wave Limb-Emission Sounder (SMILES) Level 2 (L2) data processing system.     

Changes in prevalence of subjective fatigue during 14-day 6° head-down bed rest

The present study examines the prevalence of subjective fatigue in young healthy males during 14 days of 6° head-down bed rest (HDBR) by using a multidimensional questionnaire. Forty-one subjects completed the Subjective Fatigue Scale questionnaire to assess the fatigue-related complaints and symptoms. The questionnaire is composed of three sections, with 10 items each. The sections measured drowsiness and dullness (Section 1), difficulty in concentration (Section 2), and the projection of physical disintegration (Section 3). The subjects answered simple questions between 1400 and 1700 on 6 measurement days before and during the HDBR period. The prevalence rate of low back pain was markedly high (80.5%) on the second day and more than 50% in the first half of the HDBR period, and any complaints related to either a lack of sleep or a deterioration in the quality of sleep continued until the end of the HDBR period. Our findings may be useful in developing preventive strategies against physical and mental fatigue associated with prolonged HDBR, horizontal bed rest, and microgravity environments.     

Radar beamwidth reduction techniques

It is essential and desirable to get a high resolution echo in a radar image without using a large antenna. On scanning a radar antenna, the target's distribution is smoothed by the antenna beam and a smeared echo appears on the radar display. This paper describes three different types of beam compression radars: subsurface SAR; correlation array radar; and inversion processed radar. The experimental results show that the beamwidth on display was effectively compressed by the signal processing     

The contest for leadership in East Asia: Japanese and Chinese approaches to outer space

Japan and China, as two advanced spacefaring nations in Asia-Pacific region, are often referred to as rivals in space. China's successful manned space launch program in 2003 and ASAT test in 2007 were considered as turning points which potentially introduces a “space race in Asia”. This article argues that there are three defining arenas in a space race: competition for prestige or soft power, competition over military capability or hard power, and competition of international services or public goods. It analyzes the objectives, norms and logics of space policy in Japan and China, and argues that these two countries have quite different thinking over what to do in space, explaining that they are playing different games in the first two arenas. However, Japan and China are competing for leadership and influence over the region. APRSAF and APSCO, two similar regional space organizations, are the vehicles for this competition. It concludes that there is a space race only in the third arena as a competition for leadership in Asia.     

Administrative reforms and the policy logics of Japanese space policy

The Japanese administrative reform which took place in recent years integrated NASDA and ISAS to create a larger space agency. Why was such an agency called for? What was the purpose behind the administrative reform? This article examines the motivations, objectives and responses to the reform process by using policy logic and institutional analysis to examine the evolution of the Japanese space programme. It argues that the reform aimed to rationalize the national administrative system and salvage the government from financial crisis. Thus, the reform was not designed to strengthen space activities in Japan, and as a result, Japanese space policy making is confused.     

Mesospheric nitric oxide and ozone measurements in polar winter at 69°N

Two rocket experiments were carried out just before and after the polar night at Andoya (69°N), Norway to investigate transport of nitric oxide produced by auroral processes into the middle atmosphere and its influence on the ozone chemistry. Nitric oxide densities of (2–5) × 10⁸cm⁻³ found in the 70–90 km region are one to two orders of magnitude larger than those at middle latitudes. The influence on ozone densities in the 70–90 km region due to such enhanced nitric oxide abundance is found to be insignificant as compared to that due to transport in the middle of February. The larger ozone densities found in February (in spite of longer sunlit duration) than in November in the 40–60 km region again support predominance of transport over photochemical loss.     

Transforming Japan's space policy-making

Since its beginning the objective of Japanese space policy has been to ‘catch up’ with advanced spacefaring countries. However, this catching-up strategy is now facing several difficulties, because of the downturn in the economy and changing political and technological circumstances. In such circumstances the Japanese space community has realized the need to change its national space strategy. In 2005 a group of powerful Japanese politicians issued a report on constructing a national space strategy, which recommended that the government establish a new decision-making structure by creating a new Basic Law of Space Activities. These efforts underline the need for Japanese space to shift the focus of its policy from technological development to applications.     

Assessment of space debris collisions against spacecraft with deorbit devices

Deorbit methods have been employed to remove space debris from orbit. One of these methods is to utilize atmospheric drag. In this method, a membrane loaded into the spacecraft is expanded to increase atmospheric drag. Although this method works without requiring fuel, it has the disadvantage of a high risk of collision with other debris owing to its larger area. Area-time product and energy-to-mass ratio have been used as indices to evaluate the risk of collisions between spacecraft and debris. However, the evaluation criteria were uncertain because these two indices are independent. In this paper, we propose a new evaluation index, single-sheet collision factor (SSCF), that comprehensively evaluates the collision risk based on experiments simulating debris collisions. As a result of the hypervelocity collision experiment, we found that the penetration-area mass of the spacecraft affects the severity of debris collisions. In this paper, the product of the exterior-wall thickness, the exterior-wall density, and the space debris cross-sectional area defines the penetration-area mass of the spacecraft. Furthermore, we compare and evaluate various deorbit methods using SSCF. The comparison showed that the penetration-area mass of the SSCF could be quantitatively determined for the debris-collision severity due to difference in structural materials of spacecraft. SSCF will be used to create rules for space-environment conservation with the expansion of the space-development market.