Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

激光外差干涉仪光电信号处理方法及特点

叙述和分析了外差激光干涉光电信号处理主其特点，指出了它们各自的应用范围，同时介绍了一处新型的光电信号处理方法，它不仅使外差干涉仪用于动态测量，而且可以同时实现高分辩率测量 。     

拓宽周转齿轮系的应用

本文为拓宽创新设计机构的思路,扼要地介绍了一种利用空间周转轮系,实观机械手臂的公转与自转动作要求的机构运动分析、设计方案及结构参考图。     

改进的次时间最优控制

本文在[1][2]基础上进一步探讨了次时间最优控制的改进问题,深入地阐明了次时间最优控制的某些特性后,提出了一个新的改进的设计方法。按照这种方法设计控制系统,不但实用而且可以大幅度提高次时间最优控制的最优性。并用实例比较了各种方法,证明了本文提出的方法的优越性。本文提出的方法应用于工程设计,对于提高系统的最优性是非常有效的。     

我省高职高专院校图书馆现代技术应用情况调查

目的比较与探讨不同类型高职高专图书馆现代化技术应用情况方法采用自编问卷对部分高职高专图书馆进行调查结果高职高专图书馆情况差异较大二级学院、民办学院处于前列,新高职、高专、职工大学紧随其后,挂靠学院与普通中专正在崛起。     

英语课堂教学中学生的厌烦心理及其分析

分析英语课堂教学中学生厌烦心理，转变教学观念，培养学生学习兴趣，真正发挥课堂教学的作用。     

提高压电式直线电机推力新技术

介绍了蠕动式、脉冲式、行波式及表面波式等几种压电直线电机的改进措施和进展情况，其中微脊式蠕动直线电机和表面波直线电机极有可能成为今后压电直线电机的商品化市场的新产品方向。     

滚珠丝杠螺距误差补偿法提高数控机床定位精度的研究

在详细论述、对比了实现数控机床滚珠丝杠螺距误差补偿的硬件、软件方法的原理基础上,对滚珠丝杠螺距误差软件补偿法可有效提高数控机床的定位精度进行了试验验证。     

VO2薄膜制备工艺及电阻开关特性研究

用溶胶－凝胶法在非晶玻璃上制备VO2薄膜，经过熔融、涂膜、烘干和热处理等工艺最后得到电阻相变2－3个量级的VO2薄膜。对烘干温度、熔融温度、膜厚和热处理温度对薄膜电阻开关特性的影响进行了研究。通过XRD（X－ray diffraction)和XPS（X－ray photoelectron spectroscopy）对薄膜的结构和价态进行分析，表明用溶胶－凝胶法制图VO2膜工艺简单，重复性好。     

长征运载火箭飞行过程中二级游机提前或推迟关机问题的探讨

论述了具有小推力飞行段的长征运载火箭在飞行过程中二级游机提前或推迟关机的机理,明确给出了游机可能提前或推迟关机的时间范围,为以后的火箭飞行参数判定提供理论依据。