Changes in mood status and neurotic levels during a 20-day bed rest

This study evaluated changes of mood status and depressive and neurotic levels in nine young male subjects during a 20-day 6 degrees head-down tilting bed rest and examined whether exercise training modified these changes. Participants were asked to complete psychometrical inventories on before, during, and after the bed rest experiment. Depressive and neurotic levels were enhanced during bed rest period according to the Japanese version of Zung's Self-rating Depression Scale and the Japanese version of the General Health Questionnaire. Mood state "vigor" was impaired and "confusion" was increased during bed rest and recumbent control periods compared to pre-bed rest and ambulatory control periods according to the Japanese version of Profiles of Mood State, whereas the mood "tension-anxiety", "depression-dejection", "anger-hostility" and "fatigue" were relatively stable during experiment. Isometric exercise training did not modify these results. Microgravity, along with confinement to bed and isolation from familiar environments, induced impairment of mental status.     

Psychosocial interactions during ISS missions

Based on anecdotal reports from astronauts and cosmonauts, studies of space analog environments on Earth, and our previous research on the Mir Space Station, a number of psychosocial issues have been identified that can lead to problems during long-duration space expeditions. Several of these issues were studied during a series of missions to the International Space Station. Using a mood and group climate questionnaire that was completed weekly by crewmembers in space and personnel in mission control, we found no evidence to support the presence of predicted decrements in well-being during the second half or in any specific quarter of the missions. The results did support the predicted displacement of negative feelings to outside supervisors among both crew and ground subjects. There were several significant differences in mood and group perceptions between Americans and Russians and between crewmembers and mission control personnel. Crewmembers related cohesion to the support role of their leader, and mission control personnel related cohesion to both the task and support roles of their leader. These findings are discussed with reference to future space missions.     

Interpersonal relationships in isolation and confinement: long-term bed rest in head-down tilt position

The long-term bed-rest was organized by ESA and CNES, in order to simulate the physiological effects of weightlessness: eight volunteers had to stay 42 days in bed, in a head down tilt position (-6 degrees). There were two subjects in a room, they could not be alone and it was difficult for them to have their own personal space and intimacy. In these circumstances, as in outer space, interpersonal relationships were of prime importance. This situation enabled us, through systematic observation, to analyze the evolution of the relational behavior in dyads, and to quote some social indicators of adaptation. Results show significant withdrawal, and the time spent alone was marked by the emergence, during the experiment, of specific preferential activities. Behavioral contagion was observed in each dyad (people engaged in the same activities at the same time), except in the one case of abandon. Moreover, the highest rates of inactivity and withdrawal were noted in this case. Verbal indicators were useful to comment these results and showed that, for all the dyads, one of the two subjects always played a regulating role by expressing a very positive perception of the situation. These results emphasize the importance of psycho-sociological factors in isolation and confinement. Thus, it appears that different modalities of interpersonal relationships, and not only verbal interactions, play a significant role in adaptation to stress situations.     

Preparing for life in space

The third team to inhabit the Advanced Life Support Test Chamber at the Johnson Space Center participated in an interview about life in the test chamber and program goals. Questions examine the air and water systems; human factors such as life in confinement, privacy, health, and training; and exercise. The test chamber is used to test life support systems for the International Space Station, lunar bases, and manned missions to Mars.     

Psychomotor performance during a 28 day head-down tilt with and without lower body negative pressure

Several factors may affect psychomotor performance in space: sensory-motor changes, sleep disturbances, psychological modifications induced by the social isolation and confinement. However, psychomotor performance is difficult to assess. A battery of standardized and computerized tests, so-called "Automated Portable Test System" (APTS) was devised to ascertain the cognitive, perceptive and motor abilities and their possible fluctuations according to environmental effects. Antiorthostatic bedrest, often used to simulate weightlessness, (particularly cardiovascular modifications) also constitutes a situation of social confinement and isolation. During two bedrest experiments (with head-down tilt of -6 degrees) of 28 days each, we intended to assess psychomotor performance of 6 males so as to determine whether: on the one hand, it could be altered by remaining in decubitus; on the other, the Lower Body Negative Pressure sessions, designed to prevent orthostatic intolerance back on Earth, could improve the performance. To accomplish this, part of the APTS tests as well as an automated perceptive attention test were performed. No downgrading of psychomotor performance was observed. On the contrary, the tasks were more accurately performed over time. In order to assess the experimental conditions on the acquisition phase, the learning curves were modelled. A beneficial effect of the LBNP sessions on simple tests involving the visual-motor coordination and attention faculties can only be regarded as a mere trend. Methods used in this experiment are also discussed.     

Space analogue studies in Antarctica

Medical research has been carried out on the Australian National Antarctic Research Expeditions (ANARE) for 50 years. As an extension of this program collaborative Australian/United States research on immunology, microbiology, psychology and remote medicine has produced important data and insight on how humans adapt to the stress of extreme isolation, confinement and the harsh environment of Antarctica. An outstanding analogue for the isolation and confinement of space missions (especially planetary outposts), ANARE has been used as an international research platform by Australia and the United States since 1993. Collaborative research has demonstrated a lowered responsiveness of the immune system under the isolation and confinement of Antarctic winter-over; a reduction of almost 50% in T cell proliferation to mltogen phytohaemogglutinin, as well as changes in latent herpesvirus states and the expansion of the polyclonal latent Epstein-Barr virus infected B cell populations. Although no clinically significant disease has been found to result from these immune changes, research is currently assessing the effects of psychological factors on the immune system. This and associated research performed to date and its relevance to both organisations is discussed, and comment made on possible extensions to the program in both medical and other fields.     

Male and female characteristics in vestibular testing: a step toward the selection of the best participants for space flight

Vestibular disturbances in connection with space flight were reported by a majority of participating astronauts and cosmonauts. These include motion sickness symptoms in the first few days of the space flight, as well as standing, gait and orientation disturbances after the return to Earth. The Aerospace Medical Community has been trying to select those people that are particularly adapted to the above stresses or that can be further adapted through training programs. As the circle of selectees extends to women, the problem arises as to whether differences between men and women exist under the conditions of space flight. In seeking answers to this question we studied a group of 42 women and 44 men, who were further subdivided according to their subjective motion sickness sensitivity, as determined by a questionnaire. Using this material, 26 men and 22 women were designated as motion sickness resistant, and 18 men and 20 women were designated as nonresistant. The vestibular test battery given these test subjects consisted of caloric, rotatory, optokinetic, vestibulo-spinal and vestibulo-vegetative testing. Because of the mixed orthostatic and vestibular problems seen after space flights, we also studied the response of the vestibular apparatus during peripheral blood pooling as induced by lower body negative pressure. The collected historical and test data are analyzed in this paper with emphasis on the relationship to motion sickness tendency.     

The sopite syndrome revisited: drowsiness and mood changes during real or apparent motion

The sopite syndrome is a poorly understood response to motion. Drowsiness and mood changes are the primary characteristics of the syndrome. The sopite syndrome can exist in isolation from more apparent symptoms such as nausea, can last long after nausea has subsided, and can debilitate some individuals. It is most likely a distinct syndrome from "regular" motion sickness or common fatigue, and is of potential concern in a variety of situations. The syndrome may be particularly hazardous in transportation settings where other performance challenges (e.g., sleep deprivation) are already present. It is also a potential concern in cases where illnesses such as sleep disorders or depression may interact with the syndrome and confuse diagnosis.     

Blood volume regulating hormones response during two space related simulation protocols: four-week confinement and head-down bed-rest

The volume of regulating hormones (renin, aldosterone, arginine vasopressin and atrial natriuretic factor), electrolytes and creatinine concentrations, and blood pressure were measured in two different four-week experimental protocols: respectively -6 degrees head-down bed-rest (5 subjects) and confinement (6 subjects). We observed a significant increase (P < 0.01 at D2 vs D-5) of systolic blood pressure during confinement and a different level of response for some hormones, especially for arginine vasopressin (300% increase during confinement instead of 50% during bed-rest). The renin-angiotensin-aldosterone system was enhanced during confinement and head-down bed-rest. In both conditions, we obtained a similar pattern of response for blood volume regulating hormones. During confinement, two main factors were inactivity and stress activation of the sympathetic nervous system. In the bed-rest study the response is principally due to the fluid shift and blood volume adaptation but it is not possible to exclude the role of inactivity and stress.     

Canada and the International Space Station program: overview and status

The twelve months since IAF 2000 have been perhaps the most exciting, challenging and rewarding months for Canada since the beginning of our participation in the International Space Station program in 1984. The highlight was the successful launch, on-orbit check out, and the first operational use of Canadarm2, the Space Station Remote Manipulator System, between April and July 2001. The anomalies encountered and the solutions found to achieve this success are described in the paper. The paper describes, also, the substantial progress that has been made, during the twelve months since IAF 2000, by Canada as it continues to complete work on all flight-elements of its contribution to the International Space Station and as we transition into real-time Space Station operations support and Canadian utilization. Canada's contribution to the International Space Station is the Mobile Servicing System (MSS), the external robotic system that is key to the successful assembly of the Space Station, the maintenance of its external systems, astronaut EVA support, and the servicing of external science payloads. The MSS ground segment that supports MSS operations, training, sustaining engineering, and logistics activities is reaching maturity. The MSS Engineering Support Center and the MSS Sustaining Engineering Facility are providing real-time support for on-orbit operations, and a Canadian Payloads Telescience Operations Center is now in place. Mission Controllers, astronauts and cosmonauts from all Space Station Partners continue to receive training at the Canadian Space Agency. The Remote Multi Purpose Room, one element of the MSS Operations Complex, will be ready to assume backroom support in 2002. Canada has completed work on identifying its Space Station utilization activities for the period 2000 through 2004. Also during the past twelve months the CSA drafted and is proceeding with the approval of a Canadian Space Station Commercialization Policy. Canadian astronauts have now participated in three ISS assembly missions--Julie Payette on STS-96, Marc Garneau on STS-97, and Chris Hadfield on STS-100 in April 2001 during which he performed Canada's first EVA and the successful installation of the Space Station Remote Manipulator System.     

Ethological analysis of a polar team in the French Antarctic station Dumont d'Urville as simulation of space teams for future interplanetary missions

This new ethological study focuses on the co-adaptation of the crew's spatial behavior to social isolation in a polar base thus simulating long-term living and working of a space team. The method consisted in drawing the subjects' position (n=13) on an observation map at the midday and evening meals at the Dumont d'Urville French station in Antarctica, daily during the summer campaigns and weekly during the winter-over of the TA46 mission. Quantitative data are presented in geocentric (positions), allocentric (distances) and egocentric (orientations) analyses with an emphasis on three adaptative periods (first 3 months, intermediary 2 months and last 3 months of isolation). Results show a large space occupancy during the first week after arrival and the last week before departure from the polar base, and a team-members' grouping during the winter-over. On the over-all time, the inter-individual distances increase. The social orientations are higher at the beginning than at the end of the mission. Discussion underlies the pertinent use of such ethological indicators collected from polar stations as predictors of well-being and optimal-working of the future orbital and planetary stations users.     

Transcultural group performance in extreme environment: Issues, concepts and emerging theory

A simulation for flight of international crew on space station took place in Moscow from July 1999 to April 2000 (SFINCS) at the State Biomedical Institute of Russia (IBMP) isolation chambers. Objectives of this study were to identify concepts of psychosocial adaptation and of social interactions to develop an explanation of the transcultural group performance. Method: constructivist epistemology with grounded theory research and fourth generation evaluation were used. Data on processes and interactions were gathered during 110 days of confinement as a subject and extended to 240 days as an outside scientist. Results indicate that coping is influenced by usual coping strategies and coping behaviors inside. Several stresses and human factor issues were identified altering well being and performance inside the chambers. Enabling and limiting forces are discussed. A theory on transcultural group performance is proposed. Issues are raised that appear critical to selection, training and group performance.     

Medical concerns for exploration-class missions

The Space Exploration Initiative will challenge life scientists with a diverse set of crew medical risks. The varied sources of this cumulative risk are identified and briefly discussed in terms of risk assessment and preliminary plans for risk management. The roles of Space Station Freedom and other flight programs are discussed in the context of exploration medical objectives; and the significant differences between Space Station era (second generation) and exploration medical support systems (third generation) are reviewed.     

Microgravity research results and experiences from the NASA/MIR space station program

The Microgravity Research Program (MRP) participated aggressively in Phase 1 of the International Space Station Program using the Russian Mir Space Station. The Mir Station offered an otherwise unavailable opportunity to explore the advantages and challenges of long duration microgravity space research. Payloads with both National Aeronautics and Space Agency (NASA) and commercial backing were included as well as cooperative research with the Canadian Space Agency (CSA). From this experience, much was learned about long-duration on-orbit science utilization and developing new working relationships with our Russian partner to promote efficient planning, operations, and integration to solve complexities associated with a multiple partner program.

This paper focuses on the microgravity research conducted onboard the Mir space station. It includes the Program preparation and planning necessary to support this type of cross increment research experience; the payloads which were flown; and summaries of significant microgravity science findings.     

Adaptational changes in the neural control of cardiorespiratory function in a confined environment: the CNEC#3 experiment

The goal of the study was to characterize the changes in neurovegetative control of the circulation, attending the presumed physiological and psychological stress originated by the isolation and confinement typical of the living condition of space stations, as simulated in a ground based unit, using time and frequency domain analysis. As a secondary goal we sought to verify the implementation of real time data acquisition, for off line spectral analisys of R-R interval, systolic arterial pressure (by Finapres) and respiration (by PVF2 piezoelectric sensors).

We addressed the cardiorespiratory and neurovegetative responses to standardized, simple Stressors (active standing, dynamic and static handgrip) on the EXEMSI 92 crew, before, during and after the isolation period.

On average the appropriate excitatory responses (to stand, dynamic and static handgrip) were elicited also in isolation and confinement.

Active standing and small masses muscular exercises are easy to be performed in a confined and isolated environment and provide a valuable tool for investigating the adaptational changes in neural control mechanisms.

The possibility there exists of using this time and frequency domain approach to monitor the level of performance and well being of the space crew in (quasi) real time.     

The International Space Station: a pathway to the future

Nearly six years after the launch of the first International Space Station element, and four years after its initial occupation, the United States and our 6 international partners have made great strides in operating this impressive Earth orbiting research facility. This past year we have done so in the face of the adversity of operating without the benefit of the Space Shuttle. In his January 14, 2004, speech announcing a new vision for America's space program, President Bush affirmed the United States' commitment to completing construction of the International Space Station by 2010. The President also stated that we would focus our future research aboard the Station on the long-term effects of space travel on human biology. This research will help enable human crews to venture through the vast voids of space for months at a time. In addition, ISS affords a unique opportunity to serve as an engineering test bed for hardware and operations critical to the exploration tasks. NASA looks forward to working with our partners on International Space Station research that will help open up new pathways for future exploration and discovery beyond low Earth orbit. This paper provides an overview of the International Space Station Program focusing on a review of the events of the past year, as well as plans for next year and the future.     

The challenges and opportunities of a commercial human spaceflight mission to the ISS

ESA astronauts' ISS flight opportunities are considered as a vital source to meet the utilisation, operation and political objectives that Europe has established for participating in the International Space Station programme. Recent internal ESA assessments have demonstrated that a rate of three flights per year for European Astronauts should be maintained as a minimum objective. The current flight rate is lower than this. In order to improve this situation, in the context of the activation of the ESA ISS Commercialisation programme, ESA is developing the conditions for the establishment of commercially based human spaceflights with the financial support of both ESA and the private sector or, in the future, only the latter. ESA is working in a Partnership with the space industry to facilitate the implementation of such projects and support customers with a range of end-to-end commercial services. The opportunities and challenges of a "commercial human spaceflight", involving a member of the European Astronaut Corps, or a privately employed flight participant, are discussed here.     

Multiple-task performance on a computer-simulated life support system during a space mission simulation

This paper presents an experiment which examined the effects of isolation and confinement during a simulation of a short-term space mission. During the 7-day spaceflight simulation, four Canadian astronauts were tested daily on a 30-min performance task. The task, CAMS (Cabin Air Management System), represents a computer-based simulation of a generic life support system. As a multiple-task environment, it allows the measurement of a wide range of task management variables such as primary and secondary task performance, and system control activities. Measures of subjective state variables were also taken. The results did not show any evidence of serious performance decrements for any crew member. The analysis revealed different adjustment patterns with which crew members responded as a function of mission duration and variations in workload. Among the secondary tasks employed, prospective memory was found to be more sensitive than reaction time to increases in workload. The paper concludes with a discussion of the utility of spaceflight simulations and computer-based simulations of space work.     

Microgravity research and user support in the Space Station era: The Microgravity User Support Centre

Future space systems, such as Columbus, the planned European contribution to the International Space Station, offer ample possibilities for microgravity research and application. These new opportunities require adequate user support on ground and novel operational concepts in order to ensure an effective utilization. Extensive experience in microgravity user support has been accumulated at DFVLR during the past Spacelab 1 and D1 missions. Based on this work, a Microgravity User Support Centre (MUSC) has been built and is active for the forthcoming EURECA-A1 and D2 missions, to form an integrated support centre for the disciplines life sciences and material sciences in the Space Station era. The objective of the user support at MUSC is to achieve:

&#x02022; easy access to space experiments for scientific and commercial users,

&#x02022; efficient preparation of experiments,

&#x02022; optimum use of valuable microgravity experimentation time,

&#x02022; cost reduction by concentration of experience.

This is implemented by embedding the MUSC in an active scientific environment in both disciplines, such that users can share the experience gained by professional personnel. In this way, the Space Station system is operated along the lines established on ground for the utilization of large international research facilities, such as accelerators or astronomical observatories. In addition, concepts are developed to apply advanced telescience principles for Space Station operations.     

Isolation,confinement, and sensory deprivation

Long-duration space flight involves sensory monotony, isolation, and confinement. Obviously, data from other such environments are relevant to our concerns; and the application of the concept of arousal both to interpersonal relations and to task performance in space can point to appropriate selection, training, and spacecraft design features. In the context of space flight, all of these leads remain conjectural--simulation as well as laboratory research and initiation of long-duration flights will be the crucial test of the hypotheses.