Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions

The oncogenic potential of high-energy ⁵⁶Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T1/2 cell model. The dose-averaged LET for high-energy ⁵⁶Fe is estimated to be 143 keV/μm with the exposure conditions used in this study. For ⁵⁶Fe ions, the maximum relative biological effectiveness (RBE_max) values for cell survival and oncogenic transformation were 7.71 and 16.5 respectively. Compared to 150 keV/μm ⁴He nuclei, high-energy ⁵⁶Fe nuclei were significantly less effective in cell killing and oncogenic induction. The prostaglandin E₁ analog misoprostol, an effective oncoprotector of C3H 10T1/2 cells exposed to X rays, was evaluated for its potential as a radioprotector of oncogenic transformation with high-energy ⁵⁶Fe. Exposure of cells to misoprostol did not alter ⁵⁶Fe cytotoxicity or the rate of ⁵⁶Fe-induced oncogenic transformation.     

Aerodynamic database development of the ESA intermediate experimental vehicle

This work deals with the aerodynamic database development of the Intermediate Experiment Vehicle.     

Survival of rock-colonizing organisms after 1.5 years in outer space

Cryptoendolithic microbial communities and epilithic lichens have been considered as appropriate candidates for the scenario of lithopanspermia, which proposes a natural interplanetary exchange of organisms by means of rocks that have been impact ejected from their planet of origin. So far, the hardiness of these terrestrial organisms in the severe and hostile conditions of space has not been tested over extended periods of time. A first long-term (1.5 years) exposure experiment in space was performed with a variety of rock-colonizing eukaryotic organisms at the International Space Station on board the European EXPOSE-E facility. Organisms were selected that are especially adapted to cope with the environmental extremes of their natural habitats. It was found that some-but not all-of those most robust microbial communities from extremely hostile regions on Earth are also partially resistant to the even more hostile environment of outer space, including high vacuum, temperature fluctuation, the full spectrum of extraterrestrial solar electromagnetic radiation, and cosmic ionizing radiation. Although the reported experimental period of 1.5 years in space is not comparable with the time spans of thousands or millions of years believed to be required for lithopanspermia, our data provide first evidence of the differential hardiness of cryptoendolithic communities in space.     

Validation of attitude/deformation sensing techniques for space flexible manipulators

This paper proposes an approach that makes use of two different techniques to sense and identify both the rigid attitude motion and the flexible dynamics of a manipulator. With the first technique, an accurate attitude motion determination, based on the use of a global navigation satellite systems (GNSS) signals, is performed. For this purpose, some antennas are placed on the manipulator in order to obtain the observable phase of the GNSS signal. The second technique, based on the use of accelerometer sensors, is used in order to identify the dynamic signature during the motion of the flexible link. Specifically, the modal parameters are estimated using data recorded from accelerometers, conveniently placed on the structure, by means of an output-only based approach. The developed algorithms used for both the attitude estimation and the output-only modal analysis are validated by experimental activities carried out on an in-house testbed representing a two flexible arm manipulator.     

Constant-speed target tracking via bearings-only measurements

The observability properties of the constant-speed target tracking problem via bearings-only measurements are investigated. It is shown that there exists a one-dimensional unobservable foliation which is computed. Explicit formulas are given to recover the observable part. It is shown that the direction of target trajectory is observable and that the whole state is observable if either the norm of the velocity or the distance is also known. A nonlinear observer which has a parallel structure and tolerates faults on distance measurements is presented. Finite-dimensional filters for the approximating models in the case of noisy measurements are given on the basis of output function polynomial approximations     

Catching spiral – S0 transition in groups. Insights from SPH simulations with chemo-photometric implementation

We are investigating the co-evolution of galaxies within groups combining multi-wavelength photometric and 2D kinematical observations. Here we focus on S0s showing star formation in ring/arm-like structures. We use smooth particle hydrodynamical simulations (SPH) with chemo-photometric implementation which provide dynamical and morphological information together with the spectral energy distribution (SED) at each evolutionary stage. As test cases, we simulate the evolution of two such S0s: NGC 1533 and NGC 3626.     

Galaxy evolution in groups. USGC U268 and USGC U376 in the Leo cloud

With the aim of investigating galaxy evolution in nearby galaxy groups, we analyzed the spectral energy distribution of 24 galaxies, members of two groups in the Leo cloud, USGC U268 and USGC U376. We estimated the ages and stellar masses of the galaxies by fitting their total apparent magnitudes from far-ultraviolet to near-infrared with population synthesis models. The comparison of the results for a subsample of galaxies with smooth particle hydrodynamic (SPH) simulations with chemo-photometric implementation, shows that in most cases the estimated stellar masses obtained with the two different approaches are in good agreement. The kinematical and dynamical analysis indicates that USGC U268 is in a pre-virial collapse phase while USGC U376 is likely in a more evolved phase towards virialization.