DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

Airborne radar: its beginnings in World War II

Although not realized at the time, the defeat of the German Air Force in the summer of 1940 was one of the crucial battles of World War II. The narrow margin of victory can be ascribed to Britain's air-warning radar, Chain Home (CH), consisting of the 15-meter CH and the 1.5-meter CHL. The skillful use of this equipment by the Royal Air Force made daylight bombing unsustainable; the Luftwaffe then turned to night attacks, generally called "The Blitz." These were not effective in destroying military and industrial targets and depended on the hope of reducing the population's will to fight. Chain Home was of little use except to observe the attackers arrival, as it had almost no ability to follow the attackers as they proceeded inland. This eventuality was reckoned with before the outbreak of hostilities and had called for radars mounted in night fighters capable of guiding the pilot close enough to the target for him to open fire visually. The electronic techniques used at 1.5-meters were adapted to planes capable of carrying the radar and its operator. But there were three important design constraints: 1) the antennas had to be restricted to sizes that were practical for installation on aircraft, which for meter waves gave them low gain and large side lobes; 2) the set's maximum range was limited by the fighter's altitude as a result of the huge ground returns from the side lobes. British antiaircraft artillery, the stepchild of their arms, was too ineffective to drive the bombers to extreme altitudes; and 3) a minimum range had to be held until the flier could see his target, which strained the pulse techniques of the time.     

Automotive-grade MEMS sensors used for general aviation

The attitude heading reference system (AHRS) provides data for primary flight instruments, head-up displays, autopilots, and moving map navigation systems. Advances in solid-state MEMS rate sensors, coupled with Kalman filter algorithms designed to mitigate high drift rates, provide the basis for low-cost, high-performance AHRS for general aviation. This paper describes the performance of a low cost, miniaturized AHRS using automotive-grade MEMS sensors. The performance of the system is detailed. The implications for certification of this class of system and fault tolerance are discussed.     

An experiment with an S-band radar using pulse compression andrange sidelobe suppression for meteorological measurements

A major technology barrier to the application of pulse compression for the meteorological functions required by a next generation ATC radar is range/time sidelobes which mask and corrupt observations of weak phenomena occurring near areas of strong extended meteorological scatterers. Techniques for suppressing range sidelobes are well known but without prior knowledge of the scattering medium's velocity distribution their performance degrades rapidly in the presence of Doppler. Recent investigations have presented a “doppler tolerant” range sidelobe suppression technique. The thrust of the work described herein is the extension of previous simulations to actual transmitted dispersed/coded waveforms using the S-band surveillance radar located at Rome Laboratory Surveillance Facility. The objectives of the experiment are: 1) to extend the verification of the simulation of the Doppler tolerant technique; and 2) to demonstrate that the radar transmitter, waveform generator, and receiver imperfections do not significantly degrade resolution, performance or reliability of meteorological spectral moment estimates     

Rationale for the development of the UK defence standards forsafety-critical computer software

Changes in the procurement environment and developments in technology that will require the adoption of new development certification procedures within the next few years are examined. Characteristics of safety-critical computer systems and the safety problems posed by digital computers are described. The way in which the changes have influenced the preparation of the new draft defence standards offered for public debate in the UK prior to their formal adoption by the Ministry of Defence is discussed. Principle features of the future safety-critical systems policy are outlined. The use of Ada for safety-critical software is considered     

Heliospheric and Interstellar Phenomena Deduced From Pickup ion Observations

Pickup ions, created by ionization of slow moving atoms and molecules well inside the heliosphere, provide us with a new tool to probe remote regions in and beyond the heliosphere and to study injection and acceleration processes in the solar wind. Comprehensive and continuous measurements of H, He, C, N, O, Ne and other pickup ions, especially with the Solar Wind Ion Composition Spectrometer (SWICS) on both Ulysses and ACE, have given us a wealth of data that have been used to infer chemical and physical properties of the local interstellar cloud. With SWICS on Ulysses we discovered a new population of pickup ions, produced from atomic and molecular sources deep inside the heliosphere. The velocity distributions and composition of these “inner source” pickup ions are distinctly different from those of interstellar pickup ions, showing effects of strong adiabatic cooling, and a composition resembling that of the solar wind. Strong cooling indicates that the source of these pickup ions lies close to the Sun. The similarity of composition of inner source heavy ions to that of the solar wind implies that the dominant production mechanism for these pickup ions involves the absorption and re-emission of solar wind from interplanetary dust grains. While interstellar pickup ions are the seed population of the main Anomalous Cosmic Rays (ACRs), inner source pickup ions may be an important source of the rarer ACRs such as C, Mg, Si, S, and Fe. We present new results and review previous work with an emphasis on characteristics of the local interstellar cloud and properties of the inner source. This revised version was published online in August 2006 with corrections to the Cover Date.     

Developing countries and remote sensing: how intergovernmental factors impede progress

Developing countries lag significantly behind more advanced nations in the local adoption and application of satellite remote sensing technology. Narrowing this gap through appropriate international cooperation is, however, often constrained by national interests and priorities. The paper presents an overview of several of these inter-governmental constraints using as its main basis the outcomes of recent regional and international conferences hosted by the United Nations. Future enhancement of international cooperation in remote sensing will occur best within settings where both developing and technologically advanced countries are sensitive and responsive to each other's concerns.     

The applications of lower power satellites for direct television broadcasting

The use of 12 GHz satellites for TV broadcasting directly to individual homes and small communities has been the subject of analysis and design study by groups in many countries. Implementation of the concept has been slow to follow because of the high satellite transmitter powers of from 100 to 450 W that have usually been determined to be necessary. Accumulated experience in Canada with 12 GHz operation and the evolution of technology are leading to changes in the concept of direct broadcasting such that lower power satellites may be capable of meeting the requirements.

Hermes, the Canadian/U.S. 12/14 GHz Communications Technology Satellite, has been in use for over 3 years in a program of experiments and measurements. This program has included an extensive six month experiment in direct broadcasting to 7 small communities. Experience with Hermes has shown that the signal strength is stable over long periods of time and that in Canada, significant precipitation attenuation at 12 GHz is of relatively short duration and typically occurs only during certain seasons. Operation with low propagation margins is feasible if some picture degradation and some outages at these times are acceptable. The frequency and duration of occurrence of outages can be controlled by the Earth station G/T which is cost sensitive. An individual may choose to use a low cost system with a small antenna and accept a degraded picture and outages at some times. A small community may choose to pay more for a larger antenna and lower noise receiver to achieve better performance.

Developments in technology are reducing the noise figure of mass-producible receivers from more than 6 dB to as low as 4 dB. Another technology contribution is the use of reduced bandwidth and other signal processing techniques in low-cost receivers. While use of such techniques may introduce distortions that would be unacceptable in rebroadcasting systems, there is little impact for individual and community reception. Use of both technologies reduce the required satellite EIRP or ground terminal G/T.

A field trial was begun in April 1979 to test these concepts for use in television program delivery. One hundred Earth stations capable of being tuned across a 500 MHz band and having antennas with diameters of either 1.2 m or 1.8 m are being installed for a test in Canada to receive TV signals from the 20 W transponders of ANIK-B (peak EIRP of 51 dBw) on an experimental basis. The acceptability of the video signals and the technical performance of the low-cost terminals in the bands of non-technical users are being evaluated.

The paper will summarize the concept of TV broadcasting with lower power satellites and describe the results to date of the ANIK-B field trials.     

Using computer graphics to enhance astronaut and systems safety.

Computer graphics is being employed at the NASA Johnson Space Center as a tool to perform rapid, efficient and economical analyses for man-machine integration, flight operations development and systems engineering. The Operator Station Design System (OSDS), a computer-based facility featuring a highly flexible and versatile interactive software package, PLAID, is described. This unique evaluation tool, with its expanding data base of Space Shuttle elements, various payloads, experiments, crew equipment and man models, supports a multitude of technical evaluations, including spacecraft and workstation layout, definition of astronaut visual access, flight techniques development, cargo integration and crew training. As OSDS is being applied to the Space Shuttle, Orbiter payloads (including the European Space Agency's Spacelab) and future space vehicles and stations, astronaut and systems safety are being enhanced. Typical OSDS examples are presented. By performing physical and operational evaluations during early conceptual phases. supporting systems verification for flight readiness, and applying its capabilities to real-time mission support, the OSDS provides the wherewithal to satisfy a growing need of the current and future space programs for efficient, economical analyses.