带有模型降阶的μ综合算法及应用

针对在μ综合中产生的控制器阶次高,可实现性差等实际问题,提出了一种带有平衡截断法的μ综合算法。该算法原理是通过可控可观测Ｇｒａｍｍｉａｎ阵的折中,达到降阶且保持原系统性能不变的目的。新方法不仅非常接近最优结果,而且可以使控制器阶次大大降低。     

No significant level of inheritable interchromosomal aberrations in the progeny of bystander primary human fibroblasts after alpha particle irradiation

A major concern for bystander effects is the probability that normal healthy cells adjacent to the irradiated cells become genomically unstable and undergo further carcinogenesis after therapeutic irradiation or space mission where astronauts are exposed to low dose of heavy ions. Genomic instability is a hallmark of cancer cells. In the present study, two irradiation protocols were performed in order to ensure pure populations of bystander cells and the genomic instability in their progeny were investigated. After irradiation, chromosomal aberrations of cells were analyzed at designated time points using G₂ phase premature chromosome condensation (G₂-PCC) coupled with Giemsa staining and with multiplex fluorescent in situ hybridization (mFISH). Our Giemsa staining assay demonstrated that elevated yields of chromatid breaks were induced in the progeny of pure bystander primary fibroblasts up to 20 days after irradiation. mFISH assay showed no significant level of inheritable interchromosomal aberrations were induced in the progeny of the bystander cell groups, while the fractions of gross aberrations (chromatid breaks or chromosomal breaks) significantly increased in some bystander cell groups. These results suggest that genomic instability occurred in the progeny of the irradiation associated bystander normal fibroblasts exclude the inheritable interchromosomal aberration.     

HIERARCHICAL APPROACH AND ITS APPLICATION TO INTEGRATED FLIGHT／PROPULSION CONTROL SYSTEM

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