Effects of repeated long duration +2Gz load on man's cardiovascular function

Usefulness of a short-arm human centrifuge is expected when it is used in space as a countermeasure against cardiovascular deconditioning, problem of bone-calcium metabolism, etc. However, nothing is solidly established regarding the most desirable program for artificial G application. Accordingly, this study was designed to analytically evaluate the effects of repeated long duration +Gz load on human cardiovascular function. Recently heart rate spectral analysis has been recognized as a powerful tool for quantitatively evaluating parasympathetic and sympathetic activity separately in human. It is reported that power of the high frequency component (HF-p) is mediated selectively by parasympathetic activity and the power ratio of low to high frequency components(LF/HF) is indicative of cardiac sympathetic activity or cardiac sympathovagal balance. Sequence method is developed to examine spontaneous baroreceptor reflex sensitivity (BRS). We studied cardiovascular control function by using these methods in 9 healthy men before and after 7 days of daily repeated 1hour +2Gz load. When compared with the data of pre-G load period, post-G load period, decrease of HR, increases of HF-p and BRS were statistically significant. SBP, DBP and LF/HF tended to decrease, however, these changes were not statistically significant. This results indicate that repeated +2Gz load increases parasympathetic activity and arterial baroreceptor-cardiac reflex sensitivity. In recent years, many investigators suggest that space flight and head-down bedrest leads to impaired baroreceptor-cardiac reflex responses and decrease of parasympathetic activity, which may contribute to orthostatic intolerance. So our results suggest that daily repeated 1hour +2Gz load would be useful in preventing post-flight orthostatic intolerance.     

A chirp scaling approach for processing squint mode SAR data

Image formation from squint mode synthetic aperture radar (SAR) is limited by image degradations caused by neglecting the range-variant filtering required by secondary range compression (SRC). Introduced here is a nonlinear FM chirp scaling, an extension of the chirp scaling algorithm, as an efficient and accurate approach to range variant SRC. Two methods of implementing the approach are described. The nonlinear FM filtering method is more accurate but adds a filtering step to the chirp scaling algorithm, although the extra computation is less than that of a time domain residual compression filter. The nonlinear FM pulse method consists of changing the phase modulation of the transmitted pulse, thus avoiding an increase in computation. Simulations show both methods significantly improve resolution width and sidelobe level, compared with existing SAR processors for squint angles above 10 deg for L-band and 20 deg for C-band     

Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin.

Protective effects of indomethacin, a prototype prostaglandin-inhibiting agent, against early and late sequelae of radiation injury (after X-rays or gamma rays) in mice were investigated. The following tissues or organs were examined: hematopoietic tissue, esophagus, jejunum, colon, lung, hair follicles, and tissues involved in the development of radiation-induced leg contractures. In addition, the effect of indomethacin was tested against radiation-induced carcinogenesis. In all experiments, the radiation was delivered as a single dose. Indomethacin led to significant protection of hematopoietic tissue, by a factor of 1.3. There was also some protection against radiation-induced pneumonitis and against radiation-induced carcinogenesis (protection factor of 1.2). The other tissues tested showed no change in their radioresponse after being treated with indomethacin. Thus, indomethacin can act as a radioprotective agent against both early and late sequelae of radiation, but its effect is dependent on the tissue tested. This protection is smaller than that observed with WR-2721. However, indomethacin combined with WR-2721 produced a radioprotective effect greater than the radioprotection achieved by individual treatments.     

Identification of power analysis models for ETS-III operation

This paper describes the identification of power analysis models of BOP (the Bus Equipment Operation Analysis Program) for ETS-III operation. The ETS-III (Engineering Test Satellite III) was launched in September 1982. BOP simulations are to provide prior confirmation for safe operation in terms of electrical power and thermal control situations. It is necessary to identify power analysis model first and improve the model for higher accuracy. Studies for model identification have been done by using flight data and simulation results. As a result of these studies, the power analysis model meets well with the actual ETS-III power situation and the aimed accuracy of the model has been achieved.     

KIBO (Japanese Experiment Module in ISS) operations—2008/3–2009/10

Japan Aerospace Exploration Agency (JAXA) launched its own first manned experiment facility in space called the KIBO (Japanese Experiment Module, JEM) in 2008 and 2009 and started operations as part of International Space Station (ISS). To accomplish this Operation, JAXA made its own ground facility in Tsukuba, Japan, called Space Station Integration and Promotion Center (SSIPC). Ground personnel at SSIPC called the JEM Flight Control Team (JFCT) operate the KIBO and have learnt many lessons during its operation. In this presentation, some topics are chosen and explained such as (1) crew/ground personnel interaction and (2) planning lessons learned for manned space activities.     

Issues in the implementation of the International Charter on Space and Major Disasters

The 2000 Disaster Charter initiated by the European Space Agency and the Centre National d’Etudes Spatiales is the first international mechanism to universally share remote sensing-derived information and knowledge for disaster management. It is an extensive international cooperative effort among space agencies to provide space-based assets to communities world-wide that are afflicted by disasters. After four years of operations, the Charter has successfully provided disaster relief to a number of afflicted states. Simultaneously, some deficiencies in its operational and legal provisions have been highlighted. The Charter can serve as a good case study to gain understanding of the current state and further challenges of Earth observations (EO). The purpose of this paper is to show what has been achieved through Charter operation, and to examine user requirements of EO, and what needs to be changed to serve them better.     

The effects of vacuum-UV radiation (50-190nm) on microorganisms and DNA.

Early difficulties with the light source in the study of vacuum-UV effects on biological materials were overcome largely by the introduction of the synchrotron radiation source in 1977. Highly monochromatic vacuum-UV radiation has been used to obtain action spectra of various biological targets in the range 50-190 nm. Bacillus subtilis spores were particularly suitable because of their inherent tolerance to vacuum, and action spectra for inactivation were measured down to 50 nm. Action spectra for DNA strand breaks were also measured in the same range with isolated plasmid DNA. Studies are in progress of vacuum-UV induced molecular changes in nucleic acids and their model compounds, especially of chain scission and base modification.     

Automated guidance algorithms for a space station-based crew escape vehicle.

An escape vehicle was designed to provide an emergency evacuation for crew members living on a space station. For maximum escape capability, the escape vehicle needs to have the ability to safely evacuate a station in a contingency scenario such as an uncontrolled (e.g., tumbling) station. This emergency escape sequence will typically be divided into three events: The first separation event (SEP1), the navigation reconstruction event, and the second separation event (SEP2). SEP1 is responsible for taking the spacecraft from its docking port to a distance greater than the maximum radius of the rotating station. The navigation reconstruction event takes place prior to the SEP2 event and establishes the orbital state to within the tolerance limits necessary for SEP2. The SEP2 event calculates and performs an avoidance burn to prevent station recontact during the next several orbits. This paper presents the tools and results for the whole separation sequence with an emphasis on the two separation events. The first challenge includes collision avoidance during the escape sequence while the station is in an uncontrolled rotational state, with rotation rates of up to 2 degrees per second. The task of avoiding a collision may require the use of the Vehicle's de-orbit propulsion system for maximum thrust and minimum dwell time within the vicinity of the station vicinity. The thrust of the propulsion system is in a single direction, and can be controlled only by the attitude of the spacecraft. Escape algorithms based on a look-up table or analytical guidance can be implemented since the rotation rate and the angular momentum vector can be sensed onboard and a-priori knowledge of the position and relative orientation are available. In addition, crew intervention has been provided for in the event of unforeseen obstacles in the escape path. The purpose of the SEP2 burn is to avoid re-contact with the station over an extended period of time. Performing this maneuver requires knowledge of the orbital state, which is obtained during the navigation state reconstruction event. Since the direction of the delta-v of the SEP1 maneuver is a random variable with respect to the Local Vertical Local Horizontal (LVLH) coordinate system, calculating the required SEP2 burn is a challenge. This problem was solved using elements of neural network theory for model-free function approximation and decision making.     

G2-chromosome aberrations induced by high-LET radiations.

We report measurement of initial G2-chromatid breaks in normal human fibroblasts exposed to various types of high-LET particles. Exponentially growing AG 1522 cells were exposed to gamma rays or heavy ions. Chromosomes were prematurely condensed by calyculin A. Chromatid-type breaks and isochromatid-type breaks were scored separately. The dose response curves for the induction of total chromatid breaks (chromatid-type + isochromatid-type) and chromatid-type breaks were linear for each type of radiation. However, dose response curves for the induction of isochromatid-type breaks were linear for high-LET radiations and linear-quadratic for gamma rays. Relative biological effectiveness (RBE), calculated from total breaks, showed a LET dependent tendency with a peak at 55 keV/micrometer silicon (2.7) or 80 keV/micrometer carbon (2.7) and then decreased with LET (1.5 at 440 keV/micrometer). RBE for chromatid-type break peaked at 55 keV/micrometer (2.4) then decreased rapidly with LET. The RBE of 440 keV/micrometer iron particles was 0.7. The RBE calculated from induction of isochromatid-type breaks was much higher for high-LET radiations. It is concluded that the increased production of isochromatid-type breaks, induced by the densely ionizing track structure, is a signature of high-LET radiation exposure.     

Differential positioning experiment using two geostationarysatellites

A ranging and positioning system for a ship or an aircraft using two geostationary satellites is described. This system has a ranging and positioning accuracy of 100 m and 1 km. Experiments to estimate this system were performed using a ship in the Pacific Ocean in a normal and a differential modes. This system leads to the development of fundamental ranging and positioning techniques for the cooperated independent surveillance