Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions

The oncogenic potential of high-energy ⁵⁶Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T1/2 cell model. The dose-averaged LET for high-energy ⁵⁶Fe is estimated to be 143 keV/μm with the exposure conditions used in this study. For ⁵⁶Fe ions, the maximum relative biological effectiveness (RBE_max) values for cell survival and oncogenic transformation were 7.71 and 16.5 respectively. Compared to 150 keV/μm ⁴He nuclei, high-energy ⁵⁶Fe nuclei were significantly less effective in cell killing and oncogenic induction. The prostaglandin E₁ analog misoprostol, an effective oncoprotector of C3H 10T1/2 cells exposed to X rays, was evaluated for its potential as a radioprotector of oncogenic transformation with high-energy ⁵⁶Fe. Exposure of cells to misoprostol did not alter ⁵⁶Fe cytotoxicity or the rate of ⁵⁶Fe-induced oncogenic transformation.     

Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

Optimal aeroassisted return from high earth orbit with plane change

This paper gives a complete analysis of the problem of aeroassisted return from a high Earth orbit to a low Earth orbit with plane change. A discussion of pure propulsive maneuver leads to the necessary change for improvement of the fuel consumption by inserting in the middle of the trajectory an atmospheric phase to obtain all or part of the required plane change. The variational problem is reduced to a parametric optimization problem by using the known results in optimal impulsive transfer and solving the atmospheric turning problem for storage and use in the optimization process. The coupling effect between space maneuver and atmospheric maneuver is discussed. Depending on the values of the plane change i, the ratios of the radii, $\text{n =}\text{r}{}_1\text{r}{}_2$ between the orbits and $\text{a =}\text{r}{}_2\text{R}$ between the low orbit and the atmosphere, and the maximum lift-to-drag ratio E1 of the vehicle, the optimal maneuver can be pure propulsive or aeroassisted. For aeroassisted maneuver, the optimal mode can be parabolic, which requires only drag capability of the vehicle, or elliptic. In the elliptic mode, it can be by one-impulse for deorbit and one or two-impulse in postatmospheric flight, or by two-impulse for deorbit with only one impulse for final circularization. It is shown that whenever an impulse is applied, a plane change is made. The necessary conditions for the optimal split of the plane changes are derived and mechanized in a program routine for obtaining the solution.     

Deceleration and heating constrained footprint of shuttle vehicles

With increasing frequency in shuttle operation, it is of interest to have more than one or two landing fields within the boundary of the reachable area of the reentry vehicle. This boundary, called the footprint, depends on the aerodynamic characteristics of the vehicle and is severely restricted by the deceleration and heating constraints imposed upon the atmospheric reentry trajectory. This paper gives a general assessment of the footprint as a function of various deceleration and heating constraints. The difficulties in the computation of the three-dimensional reentry trajectories with optimal modulation in both the angle-of-attack and the bank angle are alleviated by the following devices: (a) nondimensionalizing of the equations of motion and use of the density as the altitude variable; (b) use of the classical integrals of the motion; (c) transformation of the adjoint variables into physical variables; and (d) spherical rotation of the coordinates.     

Satellite Broadcasting of WWV Signals

An experiment concerning the broadcasting of time and frequency information from geostationary satellites is discussed. Included are discussions on satellite motion, time delay, Doppler shift, and delay calculations. Ground station requirements, time recovery techniques, and timing resolution and accuracy are also included. Delay computation aids for the user were designed to provide free space delays between the master clock and the user. Measurements made in North and South America demonstrated a timing resolution of about 10 ?s and an accuracy of 25 ?s.     

Clock Synchronization from Satellite Tracking

The tracking of synchronous satellites to provide propagation delays for the synchronization of clocks is described. The tracking is accomplished by range measurements to the satellite from three stations using signals transponded by the satellite. These same signals also functioned as the timing signals for the synchronization of other stations' clocks. Although the range measurements were of low resolution by usual standards, approximately 3000 meters, they provided the delays necessary to synchronize clocks to 40 microseconds or better. These results were obtained over a 4-month period using two satellites with measurements from five stations in the United States and South America.     

Characterizing Angle Tracking Radars Using Complex Variables

The receiver signal of a general angle tracking radar where there is asingle target which consists of a set of n reflectors is analyzed. It is shown how the analysis of this radar can be greatly simplified by representing the signals in the receiver as complex variables. This representation also makes it very easy to analyze such problems as scintillation and single-sideband crosstalk.     

Prostaglandin-induced radioprotection of murine intestinal crypts and villi by a PGE diene analog (SC-44932) and a PGI analog (iloprost).

The aminothiols exemplified by WR-2721 are effective radioprotectors; however, their toxicity associated with hypotension, nausea, and emesis has limited their development for applications to medicine or in harzardous radiation environments. There is a need for new radioprotectors that have fewer toxic side effects when given alone or combined with reduced amounts of thiols. A variety of prostaglandins (PGs) have been shown to be radioprotective agents and some appear to have fewer toxic side effects than the aminothiols. Iloprost, a stable PGI, analog protects the clonogenic epithelial cells of intestinal crypts but does not protect epithelial cells of the villi. In contrast, an E-series omega chain diene analog designated SC-44932 protects epithelial cells of both crypts and villi. When the two are combined, protection of the crypts is additive and the villi are protected to the same degree as when SC-44932 is given alone. Since radioprotection for some PGs has been shown to be dependent upon receptors, we suggest that the pattern of radioprotection seen with these two analogs depend on the location of the respective receptors or on the ability of differentiated villus cells to respond to PGs. By studying different analogs, we hope to identify mechanisms associated with PG-induced radioprotection and to identify the most protective PG analogs for applications of radioprotection.     

激光诊断技术在脉冲爆震发动机研究中的应用

在美国海军研究生院及斯坦福大学的脉冲爆震发动机（PDE）模型上，应用两种新发展的二极管激光诊断技术－光吸收／高温辐射组合测定法和多路复合可调二极管激光（TDL）技术，测量了其中的温度、各燃烧产物组分等重要参数，并与传统方法所得结果进行对比，说明新方法可靠、准确，适合爆震燃烧流场这种特殊环境，测量精度更高，而且更加简便、快捷。