Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

Radiation environments and absorbed dose estimations on manned space missions.

In order to make an assessment of radiation risk during manned missions in space, it is necessary first to have as accurate an estimation as possible of the radiation environment within the spacecraft to which the astronauts will be exposed. Then, with this knowledge and the inclusion of body self-shielding, estimations can be made of absorbed doses for various body organs (skin, eye, blood-forming organs, etc.). A review is presented of our present knowledge of the radiation environments and absorbed doses expected for several space mission scenarios selected for our development of the new radiation protection guidelines. The scenarios selected are a 90-day mission at an altitude (450 km) and orbital inclinations (28.5 degrees, 57 degrees and 90 degrees) appropriate for NASA's Space Station, a 15-day sortie to geosynchronous orbit and a 90-day lunar mission. All scenarios chosen yielded dose equivalents between five and ten rem to the blood forming organs if no large solar particle event were encountered. Such particle events could add considerable exposure particularly to the skin and eye for all scenarios except the one at 28.5 degrees orbital inclination.     

Occurrence of brain tumors in rhesus monkeys exposed to 55-MeV protons.

Twenty-year observation of monkeys exposed to single doses of high energy protons simulating solar particles revealed that the most prevalent fatal cancers were brain tumors in the group of animals exposed to 55-MeV protons. Of 72 animals (50 males and 22 females) receiving 0.25 to 8.0 Gy total body surface dose, nine developed fatal tumors classified as grade IV astrocytoma or glioblastoma multiforme. The latent period for tumor development ranged from 14 months to 20 years, with a median of 5 years. Doses associated with the tumors were 4.0 to 8.0 Gy. Eight males and one female were affected. Depth-dose determinations suggest that the high incidence of cerebral neoplasia is associated with the Bragg Peak energy distribution of the 55-MeV protons. Comparison of the tumor incidence with that in humans with brain exposures incidental to radiotherapy indicates a high biological effectiveness compared with gamma radiation. Studies are in progress to attempt to replicate the results in rodents and establish a dose-response curve for proton-induced brain tumors.     

THE CLUSTER ION SPECTROMETRY (CIS) EXPERIMENT

The Cluster Ion Spectrometry (CIS) experiment is a comprehensive ionic plasma spectrometry package on-board the four Cluster spacecraft capable of obtaining full three-dimensional ion distributions with good time resolution (one spacecraft spin) with mass per charge composition determination. The requirements to cover the scientific objectives cannot be met with a single instrument. The CIS package therefore consists of two different instruments, a Hot Ion Analyser (HIA) and a time-of-flight ion COmposition and DIstribution Function analyser (CODIF), plus a sophisticated dual-processor-based instrument-control and Data-Processing System (DPS), which permits extensive on-board data-processing. Both analysers use symmetric optics resulting in continuous, uniform, and well-characterised phase space coverage. CODIF measures the distributions of the major ions (H⁺, He⁺, He⁺⁺, and O⁺) with energies from ~0 to 40 keV/e with medium (22.5°) angular resolution and two different sensitivities. HIA does not offer mass resolution but, also having two different sensitivities, increases the dynamic range, and has an angular resolution capability (5.6° × 5.6°) adequate for ion-beam and solar-wind measurements.     

A parametric study of space radiation exposures to critical body organs for low earth orbit missions.

The geomagnetically-trapped and galactic cosmic radiation environments are two of the major sources of naturally-occurring space radiation exposure to astronauts in low earth orbit. The exposure is dependent primarily on altitude, spacecraft shielding, crew stay-times, and solar cycle effects for a 28.5 deg orbital inclination. Based on Space Shuttle experience, the calculated results of a parametric study are presented for several mission scenarios using a computerized anatomical man model and are compared with the NASA crew exposure limits for several critical body organs.     

Validation of the in-flight calibration procedures for the MICROSCOPE space mission

The MICROSCOPE space mission aims to test the Equivalence Principle with an accuracy of 10^-15${10}^{-15}$. The drag-free micro-satellite will orbit around the Earth and embark a differential electrostatic accelerometer including two cylindrical test masses submitted to the same gravitational field and made of different materials. The experience consists in testing the equality of the electrostatic acceleration applied to the masses to maintain them relatively motionless. The accuracy of the measurements exploited for the test of the Equivalence Principle is limited by our a priori knowledge of several physical parameters of the instrument. These parameters are partially estimated on-ground, but with an insufficient accuracy, and an in-orbit calibration is therefore required to correct the measurements. The calibration procedures have been defined and their analytical performances have been evaluated. In addition, a simulator software including the dynamics model of the instrument, the satellite drag-free system and the perturbing environment has been developed to numerically validate the analytical results. After an overall presentation of the MICROSCOPE mission, this paper will describe the calibration procedures and focus on the simulator. Such an in-flight calibration is mandatory for similar space missions taking advantage of a drag-free system.     

Impact of a novel hybrid accelerometer on satellite gravimetry performance

The state-of-the-art electrostatic accelerometers (EA) used for the retrieval of non-gravitational forces acting on a satellite constitute a core component of every dedicated gravity field mission. However, due to their difficult-to-control thermal drift in the low observation frequencies, they are also one of the most limiting factors of the achievable performance of gravity recovery. Recently, a hybrid accelerometer consisting of a regular EA and a novel cold atom interferometer (CAI) that features a time-invariant observation stability and constantly recalibrates the EA has been developed in order to remedy this major drawback. In this paper we aim to assess the value of the hybrid accelerometer for gravity field retrieval in the context of GRACE-type and Bender-type missions by means of numerical closed-loop simulations where possible noise specifications of the novel instrument are considered and different components of the Earth’s gravity field signal are added subsequently. It is shown that the quality of the gravity field solutions is mainly dependent on the CAI’s measurement accuracy. While a low CAI performance (10^?8 to 10^?9?m/s²/Hz^1/2) does not lead to any gains compared to a stand-alone EA, a sufficiently high one (10^?11?m/s²/Hz^1/2) may improve the retrieval performance by over one order of magnitude. We also show that improvements which are limited to low-frequency observations may even propagate into high spherical harmonic degrees. Further, the accelerometer performance seems to play a less prominent role if the overall observation geometry is improved as it is the case for a Bender-type mission. The impact of the accelerometer measurements diminishes further when temporal variations of the gravity field are introduced, pointing out the need for proper de-aliasing techniques. An additional study reveals that the hybrid accelerometer is – contrary to a stand-alone EA – widely unaffected by scale factor instabilities.     

Determination of the Equivalence Principle Violation Signal for the MICROSCOPE Space Mission: Optimization of the Signal Processing

The MICROSCOPE space mission aims at testing the Equivalence Principle (EP) with an accuracy of 10^?15. The test is based on the precise measurement delivered by a differential electrostatic accelerometer on-board a drag-free microsatellite which includes two cylindrical test masses submitted to the same gravitational field and made of different materials. The experiment consists in testing the equality of the electrostatic acceleration applied to the masses to maintain them relatively motionless at a well-known frequency. This high precision experiment is compatible with only very little perturbations. However, aliasing arises from the finite time span of the measurement, and is amplified by measurement losses. These effects perturb the measurement analysis. Numerical simulations have been run to estimate the contribution of a perturbation at any frequency on the EP violation frequency and to test its compatibility with the mission specifications. Moreover, different data analysis procedures have been considered to select the one minimizing these effects taking into account the uncertainty about the frequencies of the implicated signals.     

Head and neck tumors after energetic proton irradiation in rats.

This is a two-year progress report on a life span dose-response study of brain tumor risk at moderate to high doses of energetic protons. It was initiated because a joint NASA/USAF life span study of rhesus monkeys that were irradiated with 55-MeV protons (average surface dose, 3.5 Gy) indicated that the incidence of brain tumors per unit surface absorbed dose was over 19 times that of the human tinea capitis patients whose heads were exposed to 100 kv x-rays. Examination of those rats that died in the two-year interval after irradiation of the head revealed a linear dose-response for total head and neck tumor incidence in the dose range of 0-8.5 Gy. The exposed rats had a greater incidence of pituitary chromophobe adenomas, epithelial and mesothelial cell tumors than the unexposed controls but the excessive occurrence of malignant gliomas that was observed in the monkeys was absent in the rats. The estimated dose required to double the number of all types of head and neck tumors was 5.2 Gy. The highest dose, 18 Gy, resulted in high mortality due to obstructive squamous metaplasia at less than 50 weeks, prompting a new study of the relative biological effectiveness of high energy protons in producing this lesion.     

Theoretical studies of shock-initiated detonations

The dynamics of shock propagation have been studied theoretically for a variety of two-dimensional lattices. The approach used is based on molecular dynamics and hinges on the exact numerical solution by computer of the equations of motion for the individual atoms or molecules in each lattice. Shocks have been launched into the lattices under study by methods designed to simulate flyer-plate impact. Two different interatomic potentials have been used, one endothermic and one net-exothermic. For both types of potential, a shock launched at one side of the lattice will spall a group of atoms off the other side. However, the subsequent behavior of the two types of lattice is very different. For endothermic potentials, after the initial atomic spall, the residual lattice is quiescent with little further activity. For net-exothermic potentials, the initial atomic spall injects additional energy into the system in such a manner that subsequently further spall occurs at both sides. Once this new spall is initiated, it leads rapidly to further bond breaking and explosive disintegration of the system.