骨特异性转录因子Runx2对抗空间骨丢失效应的初步研究

为了构建稳定过表达Runx2 (骨特异性转录因子)的C2C12 (小鼠成肌细胞)和MG63 (前成骨细胞)细胞株, 并用于研究Runx2在对抗空间骨丢失效应中的作用. 利用实时定量聚合酶链式反应鉴定Runx2下游基因I型胶原、碱性磷酸酶表达情况, 在二维回转器中培养稳定细胞株, 通过定量聚合酶链式反应,观察在模拟失重效应下Runx2基因对其下游基因表达的影响. 结果表明, 通过筛选获得稳定转染的C2C12-Runx2和MG63-Runx2细胞株, 经鉴定都能过表达Runx2. 转染后的细胞 I 型胶原和碱性磷酸酶mRNA表达增高. 回转组与对照组相比, MG63, C2C12-Runx2, MG63-Runx2细胞的I型胶原和碱性磷酸酶mRNA表达降低, 但在模拟失重效应下, 转染细胞中I型胶原和碱性磷酸酶的mRNA表达下降程度明显低于未转染细胞株. 所构建的C2C12-Runx2和MG63-Runx2细胞株比较稳定, 并证实Runx2能部分对抗失重引起的成骨特异性分子的降低.      

多级嵌套L型阵列及其测向算法

针对基于偶数(2q)阶累积量的测向算法中测向性能提高有限的问题,提出了一种基于多级嵌套 L 型阵列的2维测向算法。首先利用阵列的多级嵌套结构和2q阶累积量,形成具有更多自由度的虚拟均匀面阵;然后使用2维平滑方法,恢复其2q阶累积量矩阵的秩; 采用2维MUSIC算法,进行方位角和俯仰角的估计。与常规的2q MUSIC 算法相比,所提算法不仅具有更好的测向精度,而且由于虚拟均匀阵包含更多的虚拟阵元,因此能够估计更多信源的方位角。另外,针对该L型阵列的最优配置问题,推导了各级子阵阵元数的最优和次优分配表达式。仿真结果表明这些结论的正确性。     

2009年1月平流层爆发性增温期间全球电离层响应的研究

2009年1月平流层爆发性增温(Stratospheric Sudden Warming, SSW)事件是有记录以来最强、持续时间最长的一次主增温事件(Major Warming Event, MWE), 期间太阳活动和地磁活动均处于较低的水平, 因此非常有利于研究电离层对平流层增温事件的响应情况. 本文利用COSMIC (Constellation Observing System for Meteorology, Ionosphere, and Climate)系统提供的掩星数据, 使用Kriging方法分别构建了此次SSW期间及平静期的电离层N_mF₂, h_mF₂和110～750km高度范围的垂直积分TEC (简称VTEC)地图, 同时从全球定位导航卫星系统服务组织(International GNSS Service, IGS)发布的全球电离层TEC地图(Global Ionospheric Maps, GIMs)中提取了日固坐标系(Sun-fixed, 地磁纬度和地方时)下全球TEC地图. 通过对比发现, SSW期间与平静期相比, 地磁纬度中低纬电离层参数存在早晨上升, 下午和夜间下降的现象. 利用OSTM/JASON-2卫星高度计观测值进行验证后的结果显示, 此前研究均未有提及的夜间时段电离层参数N_mF₂, h_mF₂和TEC (VTEC和IGS TEC)的下降现象的确存在.      

星载全球大气波动成像仪研究

在卫星上对中间层顶区域的气辉辐射成像观测, 对于全球大气波动的监测和研究具有重要的意义. 利用TDICCD对O₂A (0-0)气辉进行成像观测, 计算了曝光积分时间、信噪比和能达到的最高空间分辨率, 分析了地球自转对空间分辨率的影响, 在此基础上提出一种星载全球大气波动成像仪方案, 该方案可以观测垂直波长大于10km的大气波动, 最高水平分辨率可以达到0.33km.      

TiO2基紫外探测器的制备及退火工艺对光电性能的影响

采用磁控溅射方法,通过不同工艺的退火处理,制备了光电性能优良的TiO2基紫外探测器.通过紫外光电性能测试、扫描电子显微镜( SEM)观察及X射线衍射(XRD)分析,研究了退火工艺对探测器光电性能的影响规律.结果表明:随着退火温度的增加,TiO2晶粒尺寸显著增大,晶界和缺陷数量的变化是导致TiO2基紫外探测器的光电性能随退火工艺变化的根本原因.经500℃/2h退火后,紫外探测器的光电流高出暗电流近2.5个数量级,紫外波段的光响应高出可见光波段近2个数量级,所制备紫外探测器达到了高辐射灵敏度和可见盲特性的要求.     

2D C/SiC-ZrB2复合材料的烧蚀性能

用ZrB2微粉对2D C/SiC基体进行改性,研究了化学气相渗透结合浆料浸渍及先驱体浸渍裂解工艺制备2DC/SiC-ZrB2复合材料在氧-乙炔焰和1800℃甲烷风洞环境中的烧蚀行为.结果表明:在氧-乙炔环境中,2D C/SiC-ZrB2的线烧蚀率和质量烧蚀率分别为6.1×10-2 mm/s和1.0×10 -2g/s,相对2D C/SiC复合材料而言,ZrB2微粉并没有提高C/SiC复合材料的抗烧蚀性能.在1800℃甲烷风洞环境中,涂层致密度起主要作用,涂层致密度相同时,复合材料的开气孔率越大,质量烧蚀率越大,ZrB2微粉的渗入对C/SiC复合材料的烧蚀性能影响不大.     

星载单频GPS数据的电离层延迟改正方法分析

利用C/A码单点定位对LEO(Low Earth Orbit)卫星上的电离层延迟改正方法——"电离层比例因子法"进行了分析研究.计算的CHAMP卫星的轨道结果表明:采用电子密度峰值高度(hmF2,F2 region maximum electron density height)平均值和瞬时值计算的电离层比例因子α变化范围分别为0.3~0.4和0.2~0.65之间,两者最大差异可达0.3,相比较而言,hmF2瞬时值的结果更加合理,并且相应的大地高H方向的系统偏差要降低0.05~0.3m左右;与双频无电离层组合的普通单点定位结果相比表明该方法能较好地消除电离层一阶项所引入的H方向上的系统偏差;该方法适用的LEO卫星轨道高度范围大致在200~ 600km之间,当轨道高度超过700km时,该方法并不适用.     

Ionospheric disturbances on 8 September, 2010: Was it connected with the incoming moderate Chongqing earthquake?

Earthquake prediction stimulates the searches for a correlation between seismic activity and ionospheric anomalies. Contrary to common focuses on strong earthquakes, we report the ionospheric disturbances, 2 days before a moderate Ms = 4.7 Chongqing earthquake (29.4°N, 105.5°E, depth = 7.0 km, occurred at 21:21 LT, 10 September, 2010) with the data of ground-based ionosondes and IGS receivers. The data covering the period under the quiet geomagnetic conditions and a geomagnetic storm was analyzed with upper and lower bounds. It is found that there were significant enhancements of foF2 and total electron content (TEC) on the afternoon of 8 September, 2010, with a limited area close to the epicentre, which was different from the feature of ionospheric perturbations triggered by the geomagnetic storm on 15 September. Taking into account the heliogeomagnetical condition, we conclude that the observed ionospheric enhancements were very likely associated with the forthcoming moderate Chongqing earthquake, which implies that the relationship between the amplitudes of ionospheric disturbances and earthquakes is very complicated.     

A demonstration of the potential of Cryosat-2 to contribute to mesoscale observation

Cryosat-2 was designed for its primary scientific objectives, i.e. for cryosphere science. As far as oceanography is concerned, various mission design choices make it less accurate than missions designed to comply with ocean surface topography requirements such as Jason-2 or ENVISAT. Cryosat-2-specific errors are equivalent to more than 50% of the sea surface height variability over 40% of the oceans. Cryosat-2’s sampling pattern is also suboptimal for mesoscale observation because the satellite tracks from any consecutive period of 2 to 20 days (e.g. the most recent and most valuable data for near real time mesoscale observation) are aggregated in 500 km wide bands which are interleaved with 500 km wide observation gaps.     

Preliminary characterization of carbon dioxide transfer in a hollow fiber membrane module as a possible solution for gas–liquid transfer in microgravity conditions

In microgravity, one of the major challenge encountered in biological life support systems (BLSS) is the gas–liquid transfer with, for instance, the necessity to provide CO₂ (carbon source, pH control) and to recover the evolved O₂ in photobioreactors used as atmosphere bioregenerative systems.