Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

飞行末区目标可攻击性算法研究

分析了飞行器飞行末区存在的各种约束条件及其对飞行器飞行的影响，用最大爬升（下滑）半径约束法来代替过载约束进行飞行器纵向机动飞行的高度控制，并给出了在诸多约束条件下目标可攻击性的算法。最后利用等高线地形图进行了仿真验证，结果表明，该算法满足诸多约束要求，可用于工程应用。     

Coarse attitude determination from Earth albedo measurements

Attitude estimation algorithms for the Thrusted Vector Mission which determine attitude based on Sun sensor and very coarse albedo sensor measurements are presented. On the basis of these measurements, it has been demonstrated by comparison with more accurate gyro-based attitude that it is possible to estimate three-axis attitude with an average error per axis of 11 deg. Most of this error is about the Sun direction. Both deterministic quick-look and optimal estimates are examined     

Chromosome instability of HPRT-mutant subclones induced by ionising radiation of various LET.

The induction of HPRT-mutations and survival of Chinese hamster cells (line B11ii-FAF28, clone 431) were studied after irradiation by 4He and 12C-ions of various LET (20-360 keV/micrometers), produced by the U-200 heavy ion accelerator. The RBE increases with LET up to the maximum at 100-200 keV/micrometers and then decreases. Cytogenetic analysis was performed on the HPRT-mutant subclones selected from unirradiated Chinese hamster V-79 cells and from HPRT-mutant subclones that arose after exposure to gamma-rays, 1 GeV protons and 14N-ions (LET-77 keV/micrometers), produced by the synchrophasotron and the U-400M heavy ion accelerator. Slow growing mutant subclones were observed. The cytogenetic properties of individual clones were highly heterogeneous and chromosome instability was observed in both spontaneous and radiation-induced mutants. Chromosome instability was highest among spontaneous mutants and decreased with increasing LET.     

Controlled solar sail transfers into the near-sun orbits

We present results of numerical simulations of trajectories of a space probe with a flat solar sail which moves from a circular Earth orbit to near-Sun regions. We consider the upper limit of the sail temperature as the basic restriction. We also examine the planar (ecliptic) solar sail transfer with gravity-assist flybys around planets.     

The SOHO CELIAS/SEM EUV database from SC23 minimum to the present

The SOHO Solar EUV Monitor has been in operation since December 1995 onboard the SOHO spacecraft. This instrument is a highly stable transmission grating solar extreme ultraviolet spectrometer. It has made nearly continuous full disk solar irradiance measurements both within an 8 nm bandpass centered at 30.4 nm and throughout the 0.1 to 50 nm solar flux region since launch. The 30.4 nm flux, the 0.1 to 50 nm flux and the extracted soft X-ray (0.1 to 5 nm) flux are presented and compared with the behavior of solar proxies.     

Analysis of radiation risk from alpha particle component of solar particle events.

The solar particle events (SPE) will contain a primary alpha particle component, representing a possible increase in the potential risk to astronauts during an SPE over the often studied proton component. We discuss the physical interactions of alpha particles important in describing the transport of these particles through spacecraft and body shielding. Models of light ion reactions are presented and their effects on energy and linear energy transfer (LET) spectra in shielding discussed. We present predictions of particle spectra, dose, and dose equivalent in organs of interest for SPE spectra typical of those occurring in recent solar cycles. The large events of solar cycle 19 are found to have substantial increase in biological risk from alpha particles, including a large increase in secondary neutron production from alpha particle breakup.     

非标准H~∞控制系统结构的研究

研究了具有无穷远零点的非标准四块Ｈ∞控制系统的结构，证明了通过弓引入适当的假想被测量信号和控制信号，可将四块Ｈ∞控制的求解问题等价为一块Ｈ∞控制的求解问题。对于增广得到的一块Ｈ∞控制问题，本文证明了其广义对象的散射模型具有Ｊ－无损分解，且其中的单模矩阵因子是上三角的，此结构保证了假想被测量信号和控制信号不被利用。本文还进一步分析和揭示了Ｈ∞控制系统的无损性和对偶性。