DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

Heliospheric and Interstellar Phenomena Deduced From Pickup ion Observations

Pickup ions, created by ionization of slow moving atoms and molecules well inside the heliosphere, provide us with a new tool to probe remote regions in and beyond the heliosphere and to study injection and acceleration processes in the solar wind. Comprehensive and continuous measurements of H, He, C, N, O, Ne and other pickup ions, especially with the Solar Wind Ion Composition Spectrometer (SWICS) on both Ulysses and ACE, have given us a wealth of data that have been used to infer chemical and physical properties of the local interstellar cloud. With SWICS on Ulysses we discovered a new population of pickup ions, produced from atomic and molecular sources deep inside the heliosphere. The velocity distributions and composition of these “inner source” pickup ions are distinctly different from those of interstellar pickup ions, showing effects of strong adiabatic cooling, and a composition resembling that of the solar wind. Strong cooling indicates that the source of these pickup ions lies close to the Sun. The similarity of composition of inner source heavy ions to that of the solar wind implies that the dominant production mechanism for these pickup ions involves the absorption and re-emission of solar wind from interplanetary dust grains. While interstellar pickup ions are the seed population of the main Anomalous Cosmic Rays (ACRs), inner source pickup ions may be an important source of the rarer ACRs such as C, Mg, Si, S, and Fe. We present new results and review previous work with an emphasis on characteristics of the local interstellar cloud and properties of the inner source. This revised version was published online in August 2006 with corrections to the Cover Date.     

Scientific Planning and Commanding of the Rosetta Payload

ESA’s Rosetta mission was launched in March 2004 and is on its way to comet 67P/Churyumov-Gerasimenko, where it is scheduled to arrive in summer 2014. It comprises a payload of 12 scientific instruments and a Lander. All instruments are provided by Principal Investigators, which are responsible for their operations. As for most ESA science missions, the ground segment of the mission consists of a Mission Operations Centre (MOC) and a Science Operations Centre (SOC). While the MOC is responsible for all spacecraft-related aspects and the final uplink of all command timelines to the spacecraft, the scientific operations of the instruments and the collection of the data and ingestion into the Planetary Science Archive are coordinated by the SOC. This paper focuses on the tasks of the SOC and in particular on the methodology and constraints to convert the scientific goals of the Rosetta mission to operational timelines.     

Developing countries and remote sensing: how intergovernmental factors impede progress

Developing countries lag significantly behind more advanced nations in the local adoption and application of satellite remote sensing technology. Narrowing this gap through appropriate international cooperation is, however, often constrained by national interests and priorities. The paper presents an overview of several of these inter-governmental constraints using as its main basis the outcomes of recent regional and international conferences hosted by the United Nations. Future enhancement of international cooperation in remote sensing will occur best within settings where both developing and technologically advanced countries are sensitive and responsive to each other's concerns.     

The applications of lower power satellites for direct television broadcasting

The use of 12 GHz satellites for TV broadcasting directly to individual homes and small communities has been the subject of analysis and design study by groups in many countries. Implementation of the concept has been slow to follow because of the high satellite transmitter powers of from 100 to 450 W that have usually been determined to be necessary. Accumulated experience in Canada with 12 GHz operation and the evolution of technology are leading to changes in the concept of direct broadcasting such that lower power satellites may be capable of meeting the requirements.

Hermes, the Canadian/U.S. 12/14 GHz Communications Technology Satellite, has been in use for over 3 years in a program of experiments and measurements. This program has included an extensive six month experiment in direct broadcasting to 7 small communities. Experience with Hermes has shown that the signal strength is stable over long periods of time and that in Canada, significant precipitation attenuation at 12 GHz is of relatively short duration and typically occurs only during certain seasons. Operation with low propagation margins is feasible if some picture degradation and some outages at these times are acceptable. The frequency and duration of occurrence of outages can be controlled by the Earth station G/T which is cost sensitive. An individual may choose to use a low cost system with a small antenna and accept a degraded picture and outages at some times. A small community may choose to pay more for a larger antenna and lower noise receiver to achieve better performance.

Developments in technology are reducing the noise figure of mass-producible receivers from more than 6 dB to as low as 4 dB. Another technology contribution is the use of reduced bandwidth and other signal processing techniques in low-cost receivers. While use of such techniques may introduce distortions that would be unacceptable in rebroadcasting systems, there is little impact for individual and community reception. Use of both technologies reduce the required satellite EIRP or ground terminal G/T.

A field trial was begun in April 1979 to test these concepts for use in television program delivery. One hundred Earth stations capable of being tuned across a 500 MHz band and having antennas with diameters of either 1.2 m or 1.8 m are being installed for a test in Canada to receive TV signals from the 20 W transponders of ANIK-B (peak EIRP of 51 dBw) on an experimental basis. The acceptability of the video signals and the technical performance of the low-cost terminals in the bands of non-technical users are being evaluated.

The paper will summarize the concept of TV broadcasting with lower power satellites and describe the results to date of the ANIK-B field trials.     

声激励增升效应研究

二元后台阶低速风洞实验表明,用内部声激励控制脱落旋涡能够获得有利的增升效应。实验还得出激励频率、旋涡自然脱落主频及旋涡脱落主频之间的关系;并给出了模型表面压力随声压级及频率变化的规律。本文将对二元翼型及三角翼等内部声激励的应用研究提供有价值的实验结果。     

Comparison of ≳40 keV Electron Events at High and Low Heliolatitudes: Ulysses/HI-SCALE and ACE/EPAM

We have performed a joint survey of anisotropic ≳40 keV electron events from August 1997 to September 2000 using the matched detectors on the Ulysses (ULS)/HI-SCALE and the ACE/EPAM instruments. A computer algorithm selected events with strong, statistically significant pitch-angle anisotropies. Electron pitch-angle distributions at ACE (∼1 AU) are often ‘beams’ that are strongly collimated along the local interplanetary magnetic field (IMF). These flare-associated impulsive injections can display rapid rise times (∼15 min) and slower decays, or more irregular intensity histories. At ULS, the electron intensities are lower and the time histories smoother, but strong anisotropies are still observable, indicating direct, nearly field-aligned propagation outward from the Sun. We focus on four event periods, selected from the survey, during times when the angle between the footpoints of the IMF lines intersecting ACE and ULS is small. These events span three full years and cover a wide range of distances and heliographic latitudes. We found one reasonably good association between impulsive electron events at ACE and ULS, and two events with small field-aligned gradients. This revised version was published online in August 2006 with corrections to the Cover Date.     

Atomic and molecular hydrogen in interstellar space

This paper reviews the present state of knowledge of the abundances and physical state of interstellar atomic and molecular hydrogen. Much new data in this area have been obtained in recent rocket observations. There have also been new developments as a result of ground-based infrared and 21-cm observations, and theoretical research.Rocket observations of the Lyman- interstellar absorption line of atomic hydrogen indicate that, in many directions in the sky, atomic hydrogen is up to a factor of 10 less abundant than previously indicated by 21-cm emission measurements. In the direction of the Orion Nebula, most of the absorbing gas appears to be concentrated in the near vicinity of the nebula and to have a temperature considerably lower than the average of 100 K obtained from 21-cm emission measurements. Molecular hydrogen appears essentially absent from the general interstellar medium, as confirmed by theoretical studies of photodissociation processes. However, ground-based infrared and 21-cm studies indicate that the hydrogen in dark dust clouds is mostly molecular.     

工件表面轮廓均方根斜率的光散射测量

描述并确定具有明显纹理粗糙表面均方根斜率的光散射技术(均方根斜率是联合表面轮廓高度和波长特性的混合参数)。称为散射光锥法(The scattered light-conemethod)的该技术是基于激光角散射检测阵列(DALLAS——Defector Array for Laser LishtAngular Scattering),它用于测量粗糙表面散射光角分布的仪器。均方根斜率是从DALLAS光散射图象的角宽得到的。一般可以发现角宽(即估计的均方根斜率)对光的入射角和散射角变化相当大时是不敏感的。这些结果与表面材料无关,并且对正弦和随机粗糙表面都是有效的。介绍了散射光锥法的测量原理、实验、数据分析和几点结论。     

The Relativistic Proton Spectrometer (RPS) for the Radiation Belt Storm Probes Mission

The Relativistic Proton Spectrometer (RPS) on the Radiation Belt Storm Probes spacecraft is a particle spectrometer designed to measure the flux, angular distribution, and energy spectrum of protons from ～60 MeV to ～2000 MeV. RPS will investigate decades-old questions about the inner Van Allen belt proton environment: a nearby region of space that is relatively unexplored because of the hazards of spacecraft operation there and the difficulties in obtaining accurate proton measurements in an intense penetrating background. RPS is designed to provide the accuracy needed to answer questions about the sources and losses of the inner belt protons and to obtain the measurements required for the next-generation models of trapped protons in the magnetosphere. In addition to detailed information for individual protons, RPS features count rates at a 1-second timescale, internal radiation dosimetry, and information about electrostatic discharge events on the RBSP spacecraft that together will provide new information about space environmental hazards in the Earth’s magnetosphere.