Choroidal responses in microgravity. (SLS-1, SLS-2 and hindlimb-suspension experiments)

Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity.     

Disk Evolution and the Fate of Water

Space Science Reviews - We review the general theoretical concepts and observational constraints on the distribution and evolution of water vapor and ice in protoplanetary disks, with a focus on...     

基于神经网络的智能刀具状态检测系统

可靠的在线刀具磨损状态检测是柔性制造系统、计算机集成制造系统以及自动化机床必不可少的一个环节。文中论述了用反传神经网络与一类模糊神经网络分析处理由力传感器和声发射传感器所测得的刀具状态信号，识别出刀具的磨损情况，从而进一步实现刀具磨损状态的在线检测，控制自动机床及时更换刀具。本研究对四种规格的钻头的磨损情况进行了全程检测，并比较分析了反传神经网络与模糊神经网络对这一问题的有效性。实验结果表明，这两种方法对处理刀具磨损状态检测均有显著的效果与很高的准确性。用一类模糊神经网络处理多传感器信息是实现刀具状态在线检测的一个极为有效的方法。     

The contributions of the incoherent scatter radar technique to the development of thermospheric models

The contributions of the incoherent scatter radar technique to the development of thermospheric models is traced from the development of the radar technique in 1958. Emphasis is given to the qualitative information regarding thermospheric processes and behavior provided by the radar studies and the role that these results have played in the structural development of thermospheric models. The complementary nature of radar and satellite data in the development of recent models is stressed. In addition, a summary of pertinent radar developments over the past two years is presented. Primary among these are measurements made by high-latitude radars, multi-radar coordinated observations, the establishment of an incoherent scatter radar data base, and publication of a number of studies concerning high-latitude measurements, solar-cyle maximum results, long-term data sets, and lower thermosphere tides.     

Using natural features for vision based navigation of an indoor-VTOL MAV

The use of natural features for vision based navigation of an indoor Vertical-Take-Off-and-Landing (VTOL) Micro Aerial Vehicle (MAV) named Air-Quad is presented. Air-Quad is a small four-rotor helicopter developed at the ITE.Such a helicopter needs reliable attitude information. The measurements of the used MEMS gyroscopes and accelerometers are corrupted by strong noise. To be useful, the MEMS sensors have to be part of an integrated navigation system with aiding through complementary sensors like GPS or the computer vision module presented here.In the computer vision module, feature points are detected and tracked through the image sequence. The relative rotation and translation of the camera are estimated using the two-dimensional motion of the feature points.The three-dimensional points in the scene are modeled with the image coordinates of their first sighting and their inverse depths. Only these inverse depths are estimated for the feature points. An efficient sparse bundle adjustment algorithm is used to improve the estimation of the scene structure and the navigation solution.It is shown that the use of the computer vision module greatly improves the navigation solution compared to a solution based only on MEMS sensors.     

Geometric accuracy in airborne SAR images

Uncorrected across-track motions of a synthetic aperture radar (SAR) platform can cause both a severe loss of azimuthal positioning accuracy in, and defocusing of, the resultant SAR image. It is shown how the results of an autofocus procedure can be incorporated in the azimuth processing to produce a fully focused image that is geometrically accurate in azimuth. Range positioning accuracy is also discussed, leading to a comprehensive treatment of all aspects of geometric accuracy. The system considered is an X-band SAR     

Extraterrestrial Organic Matter and the Detection of Life

A fundamental goal of a number of forthcoming space missions is the detection and characterization of organic matter on planetary surfaces. Successful interpretation of data generated by in situ experiments will require discrimination between abiogenic and biogenic organic compounds. Carbon-rich meteorites provide scientists with examples of authentic extraterrestrial organic matter generated in the absence of life. Outcomes of meteorite studies include clues to protocols that will enable the unequivocal identification of organic matter derived from life. In this chapter we summarize the diagnostic abiogenic features of key compound classes involved in life detection and discuss their implications for analytical instruments destined to fly on future spacecraft missions.     

Urey: Mars Organic and Oxidant Detector

One of the fundamental challenges facing the scientific community as we enter this new century of Mars research is to understand, in a rigorous manner, the biotic potential both past and present of this outermost terrestrial-like planet in our solar system. Urey: Mars Organic and Oxidant Detector has been selected for the Pasteur payload of the European Space Agency’s (ESA’s) ExoMars rover mission and is considered a fundamental instrument to achieve the mission’s scientific objectives. The instrument is named Urey in recognition of Harold Clayton Urey’s seminal contributions to cosmochemistry, geochemistry, and the study of the origin of life. The overall goal of Urey is to search for organic compounds directly in the regolith of Mars and to assess their origin. Urey will perform a groundbreaking investigation of the Martian environment that will involve searching for organic compounds indicative of life and prebiotic chemistry at a sensitivity many orders of magnitude greater than Viking or other in situ organic detection systems. Urey will perform the first in situ search for key classes of organic molecules using state-of-the-art analytical methods that provide part-per-trillion sensitivity. It will ascertain whether any of these molecules are abiotic or biotic in origin and will evaluate the survival potential of organic compounds in the environment using state-of-the-art chemoresistor oxidant sensors.     

A composite focal plane assembly for the GERB instrument

In this paper, we present the design and construction of a composite focal plane assembly (FPA) for the Geostationary Earth Radiation Budget (GERB) Earth observing, visible–infrared imaging radiometer. The FPA is a complex structure that incorporates a number of features aimed at reducing mass, power and volume. These include the use of silicon and ceramic substrates for high density tracking and temperature stabilisation, removable test structures for component verification prior to final assembly and high levels of integration.