Usefulness of daily +2Gz load as a countermeasure against physiological problems during weightlessness.

Adaptation to head-down-tilt bed rest as a simulated microgravity leads to an abnormality of reflex control of circulation, hypovolemia and reduction of exercise capacity. We hypothesized that this cardiovascular deconditioning and reduction of exercise capacity could be prevented by a daily 1 hr centrifugation at +2Gz. To test this hypothesis, twenty healthy male subjects underwent 4 day of 6 degrees head-down-tilt bed rest. Ten of them were exposed to a +2Gz load for up to 30 min twice per day (the Gz group). The remaining 10 were not exposed to a Gz load (the no-Gz group). We estimated autonomic cardiovascular control by power spectral analysis of blood pressure and R-R interval variability, and baroreflex regulation by the transfer function analysis and the sequence method, before and after bed rest. Further, we measured hematocrit as an index of changes in plasma volume and maximal oxygen consumption as an index of exercise capacity, before and after bed rest. Result: In the no-Gz group, heart rate increased after bed rest. The high frequency power of R-R interval variability as an index of cardiac parasympathetic nervous activity, baroreflex gains estimated by transfer function analysis and the sequence method as index of the integrated arterial-cardiac baroreflex function decreased significantly. Associated with these changes, the ratio of low to high frequency power of R-R as an indicator of cardiac sympathovagal balance tended to increase after bed rest in the no-Gz group. However, those showed no significant changes after bed rest in the Gz group. Hematocrit increased after bed rest in the no-Gz group. It also tended to increase in the Gz group, however it did not achieve statistical significance. Maximal oxygen consumption decreased significantly to similar extent in both the groups. Conclusion: This result suggested that 1) a daily 1hr +2Gz load produced by a centrifuge might eliminate the changes in autonomic cardiovascular control during simulated weightlessness; 2) furthermore, it might partly reverse hypovolemia induced by bed rest; 3) however, it could not prevent the decreases in exercise capacity.     

Effects of repeated long duration +2Gz load on man's cardiovascular function

Usefulness of a short-arm human centrifuge is expected when it is used in space as a countermeasure against cardiovascular deconditioning, problem of bone-calcium metabolism, etc. However, nothing is solidly established regarding the most desirable program for artificial G application. Accordingly, this study was designed to analytically evaluate the effects of repeated long duration +Gz load on human cardiovascular function. Recently heart rate spectral analysis has been recognized as a powerful tool for quantitatively evaluating parasympathetic and sympathetic activity separately in human. It is reported that power of the high frequency component (HF-p) is mediated selectively by parasympathetic activity and the power ratio of low to high frequency components(LF/HF) is indicative of cardiac sympathetic activity or cardiac sympathovagal balance. Sequence method is developed to examine spontaneous baroreceptor reflex sensitivity (BRS). We studied cardiovascular control function by using these methods in 9 healthy men before and after 7 days of daily repeated 1hour +2Gz load. When compared with the data of pre-G load period, post-G load period, decrease of HR, increases of HF-p and BRS were statistically significant. SBP, DBP and LF/HF tended to decrease, however, these changes were not statistically significant. This results indicate that repeated +2Gz load increases parasympathetic activity and arterial baroreceptor-cardiac reflex sensitivity. In recent years, many investigators suggest that space flight and head-down bedrest leads to impaired baroreceptor-cardiac reflex responses and decrease of parasympathetic activity, which may contribute to orthostatic intolerance. So our results suggest that daily repeated 1hour +2Gz load would be useful in preventing post-flight orthostatic intolerance.     

Changes in prevalence of subjective fatigue during 14-day 6° head-down bed rest

The present study examines the prevalence of subjective fatigue in young healthy males during 14 days of 6° head-down bed rest (HDBR) by using a multidimensional questionnaire. Forty-one subjects completed the Subjective Fatigue Scale questionnaire to assess the fatigue-related complaints and symptoms. The questionnaire is composed of three sections, with 10 items each. The sections measured drowsiness and dullness (Section 1), difficulty in concentration (Section 2), and the projection of physical disintegration (Section 3). The subjects answered simple questions between 1400 and 1700 on 6 measurement days before and during the HDBR period. The prevalence rate of low back pain was markedly high (80.5%) on the second day and more than 50% in the first half of the HDBR period, and any complaints related to either a lack of sleep or a deterioration in the quality of sleep continued until the end of the HDBR period. Our findings may be useful in developing preventive strategies against physical and mental fatigue associated with prolonged HDBR, horizontal bed rest, and microgravity environments.     

Paths not taken – The Gossamer roadmap’s other options

Highly efficient low-thrust propulsion is increasingly applied beyond commercial use, also in mainstream and flagship science missions, in combination with gravity assist propulsion. Another recent development is the growth of small spacecraft solutions, not in size but in numbers and individual capabilities.Just over ten years ago, the DLR-ESTEC Gossamer Roadmap to Solar Sailing was set up to guide technology developments towards a propellant-less and highly efficient class of spacecraft for solar system exploration and applications missions: small spacecraft solar sails designed for carefree handling and equipped with carried application modules.Soon, in three dedicated Gossamer Roadmap Science Working Groups it initiated studies of missions uniquely feasible with solar sails such as Displaced L₁ (DL1) space weather advance warning and monitoring, Solar Polar Orbiter (SPO) delivery to very high inclination heliocentric orbit, and multiple Near-Earth Asteroid (NEA) rendezvous (MNR). Together, they demonstrate the capability of near-term solar sails to achieve at least in the inner solar system almost any kind of heliocentric orbit within 10 years, from the Earth-co-orbital to the extremely inclined, eccentric and even retrograde. Noted as part of the MNR study, sail-propelled head-on retrograde kinetic impactors (RKI) go to this extreme to achieve the highest possible specific kinetic energy for the deflection of hazardous asteroids.At DLR, the experience gained in the development of deployable membrane structures leading up to the successful ground deployment test of a (20 m)², i.e., 20 m by 20 m square solar sail at DLR Cologne in 1999 was revitalized and directed towards a 3-step small spacecraft development line from as-soon-as-possible sail deployment demonstration (Gossamer-1) via in-flight evaluation of sail attitude control actuators (Gossamer-2) to an envisaged proving-the-principle flight in the Earth-Moon system (Gossamer-3). First, it turned the concept of solar sail deployment on its head by introducing four separable Boom Sail Deployment Units (BSDU) to be discarded after deployment, enabling lightweight 3-axis stabilized sailcraft. By 2015, this effort culminated in the ground-qualified technology of the DLR Gossamer-1 deployment demonstrator Engineering Qualification Model (EQM). For mission types using separable payloads, such as SPO, MNR and RKI, design concepts can be derived from the BSDU characteristic of DLR Gossamer solar sail technology which share elements with the separation systems of asteroid nanolanders like MASCOT. These nano-spacecraft are an ideal match for solar sails in micro-spacecraft format whose launch configurations are compatible with ESPA and ASAP secondary payload platforms.Like any roadmap, this one contained much more than the planned route from departure to destination and the much shorter distance actually travelled. It is full of lanes, narrow and wide, detours and shortcuts, options and decision branches. Some became the path taken on which we previously reported. More were explored along the originally planned path or as new sidings in search of better options when circumstance changed and the project had to take another turn. But none were dead ends, they just faced the inevitable changes when roadmaps face realities and they were no longer part of the road ahead. To us, they were valuable lessons learned or options up our sleeves. But for future sailors they may be on their road ahead.     

Comparison of gradual and rapid onset runs in a short-arm centrifugation

A gradual onset run (GOR) in a short-arm centrifugation was performed on ten healthy students. The centrifuge had a 1.8 m radius, and the subjects sat on a chair in a cabin. The Gz force increased to 2.2 Gz at 0.1 °/sec² for 32 min. and the same Gz-level was maintained for 20 min. Three out of ten subjects completed the whole protocol; the load on the others was terminated because of symptoms or increased heart rate. There were few symptoms such as vertigo, that was a common problem with a rapid onset run (ROR) in former experiments, due to the short-arm centrifugation. The changes of the flicker test after the load were much less in the GOR protocol than in the ROR protocol, even in the terminated group. GOR seemed preferable to ROR in preventing vertigo even though it took longer to reach the necessary G load.