Countermeasure Against Regenerative and Forced Chatter of Flexible Workpieces in Milling Processs Using Bi-directional Excitation

A novel extended methodology for chatter suppression in milling process by applying external forced vibrations to the workpiece in two orthogonal directions which are the feed and cross-feed directions.Both the regenerative and forced chatter suppression during the milling process of flexible workpieces are investigated.Here,the workpiece is subject to a sinusoidal periodic force in the feed direction to disrupt the regenerative effect.Additionally,to minimize the forced chatter,the workpiece is subject to the periodic excitation force in cross-feed direction.This force is proportional to the magnitude of the estimated cutting force in cross-feed direction and has a phase opposite to the cutting force to minimize the vibration amplitudes.The effectiveness of the proposed method is evaluated numerically and experimentally,for the spindle speed located in both the local minima and local maxima of the stability lobe diagram.The numerical simulations indicate significant suppression effect in terms of vibration amplitudes,resulting in suppression of both the regenerative chatter and the forced chatter.Experiments were conducted by using a workpiece-mounted active stage composed of flexure hinges and driven by piezoelectric actuators.The experimental results agree qualitatively with the numerical simulations.The proposed method indicates a remarkable vibration reduction effect for both regenerative and forced chatters.     

Residual chromatin breaks as biodosimetry for cell killing by carbon ions

We have studied the relationship between cell killing and the induction of residual chromatin breaks on various human cell lines and primary cultured cells obtained by biopsy from patients irradiated with either X-rays or heavy-ion beams to identify potential bio-marker of radiosensitivity for radiation-induced cell killing. The carbon-ion beams were accelerated with the Heavy Ion Medical Accelerator in Chiba (HIMAC). Six primary cultures obtained by biopsy from 6 patients with carcinoma of the cervix were irradiated with two different mono-LET beams (LET= 13 keV/μm, 76 keV/μm) and 200kV X rays. Residual chromatin breaks were measured by counting the number of non-rejoining chromatin fragments detected by the premature chromosome condensation (PCC) technique after a 24 hour postirradiation incubation period. The induction rate of residual chromatin breaks per cell per Gy was the highest for 76 keV/μm beams on all of the cells. Our results indicated that cell which was more sensitive to the cell killing was similarly more susceptible to induction of residual chromatin breaks. Furthermore there is a good correlation between these two end points in various cell lines and primary cultured cells. This suggests that the detection of residual chromatin breaks by the PCC technique may be useful as a predictive assay of tumor response to cancer radiotherapy.     

Effects of carbon ions on primary cultures of mouse brain cells.

Primary mixed cultures of astrocytes and microglia were obtained from neonatal mice, and were irradiated with high-LET carbon ions. Immunohistochemical staining showed astrocytes survived more prominently than microglia. Tagged with specific antibodies, astrocytes and microglia surviving after irradiation were counted by flow cytometry. Decreases in the number of microglia and astrocytes were detected at a dose as small as 2 Gy when Day 5 cultures were irradiated with 13 keV/micrometer carbon ions. When the cultures were irradiated on Day 10, the dose-dependent decrease of microglia was more prominent for 13 keV/micrometer carbon ions than 70 keV/micrometer carbon ions. Astrocytes showed a marginal decrease at Day 10 and Day 14. We concluded that microglia are more sensitive than astrocytes to carbon ions and X-rays, and that the radiosensitivity of microglia depends on both differentiation/proliferation status and radiation quality.     

High-resolution observations of Hα flare regions

This paper gives a review of the recent high-resolution H observations of solar flares and flare-productive active regions. From studies of the morphological and evolutional features of H flare emitting regions, two types of two-ribbon flares, which are termed separating two-ribbon flare and confined two-ribbon flare, are discussed. The former is characterized by conspicuous separating motions or expanding motions of the H two ribbons, whereas the latter shows only a short range of or no separating motions of the two ribbons. The explosive compact flares, which occur in some compact newly-emerging flux regions, are also discussed.Attention is paid to the successive and impulsive brightenings of H flare points which form the H flare kernels and the front lines of H two ribbons at the impulsive phases of flares. Temporal relationships between H line intensities or profiles and hard X-ray or microwave emissions are discussed to discriminate the energy transport mechanisms in the flare loops.H monochromatic image of high spatial resolution, at the present time, is the most sensitive detector for finding the first appearance of newly-emerging magnetic flux region and the developing features of sheared configuration of magnetic field, both of which are the key factors in flare energy build-up processes. It is suggested that the successive emergence of a twisted magnetic flux rope might be essential for the production of a major flare.Contributions from the Kwasan and Hida Observatories, Kyoto University, No. 292.     

Rotational Motions Excited by Vertical Harmonic Motions

Rotation of a pair of wings was driven by the vertical harmonic motion of a pin inserted into the center hole of the wings.To elucidate the mechanism by which the rotational motion of the wings was excited,the relationship between the wings and the pin was examined by tracking their motions using both displacement measurements and high-speed photography.The motion modes occurred in this study were categorized into five types:slipping,rolling,jumping(without eccentricity),jumping(with eccentricity),and non-rotation.In the case that the hole of the wings was located at a distance from the center of the wings,referred to as″with eccentricity,″the slipping,jumping(with eccentricity),and non-rotation modes resulted.The experimental results showed that the mechanism of the jumping(with eccentricity)was different from that of the other modes(slipping,rolling,jumping(without eccentricity)),which are well known to be driven by the periodical reaction of the wings against the vertical vibration of the pin.It was found that the jumping(with eccentricity)was driven by the non-periodical force with the collision between the wing hole and the pin.     

Orbital design and technological feasibility of Halley mission

Missions to Halley's comet in 1985–1986 are discussed. They include pre-perihelion encounter, post-perihelion encounter, the utilization of Venus swing-by, one round mission in which the spacecraft goes the round of the Sun before the encounter and missions to the point beneath the perihelion of Halley's orbit. Technological feasibility of the small spacecraft is also discussed on the basis of the use of the improved version of M-3S launch vehicle.     

Microsatellite instability in human mammary epithelial cells transformed by heavy ions

We analyzed DNA and proteins obtained from normal and transformed human mammary epithelial cells for studying the neoplastic transformation by high-LET irradiation in vitro. We also examined microsatellite instability in human mammary cells transformed to various stages of carcinogenesis, such as normal, growth variant and tumorigenic, using microsatellite marker D5S177 on the chromosome 5 and CY17 on the Chromosome 10. Microsatellite instabilities were detected in the tumorigenic stage. These results suggest that microsatellite instability may play a role in the progression of tumorigenecity. The cause of the genomic instability has been suggested as abnormalities of DNA-repair systems which may be due to one of the three reasons: 1) alterations of cell cycle regulating genes. 2) mutations in any of the DNA mismatch repair genes. 3) mutation in any of the DNA strand breaks repair genes. No abnormality of these genes and encoded proteins, however was found in the present studies. These studies thus suggest that the microsatellite instability is induced by an alternative mechanism.     

Correlation between cell death and induction of non-rejoining PCC breaks by carbon-ion beams.

We have shown a correlation between cell death and induction of non-rejoining chromatin breaks in two normal human cells and three human tumor cell lines irradiated by carbon-ion beams and X rays. Non-rejoining chromatin breaks were measured by counting the number of remaining chromatin fragments detected by the premature chromosome condensation (PCC) technique. Carbon-ion beams were accelerated by the Heavy Ion Medical Accelerator in Chiba (HIMAC). The cells were irradiated by two different mono-LET beams (LET = 13 keV/micrometer and 77 keV/micrometer ) and 200 kV X rays. The RBE values of cell death for carbon-ion beams relative to X rays were 1.1 to 1.4 for 13 keV/micrometer beams and 2.5 to 2.9 for 77 keV/micrometer beams. The induction rate of non-rejoining PCC breaks per cell per Gy was found to be highest for the 77 keV/micrometer beams for all of the cell lines.The results found in this study show that there is a good correlation between cell death and induction of non-rejoining PCC breaks for these human cell lines.     

Studying the Lunar Ionosphere with SELENE Radio Science Experiment

Radio occultation observations of the electron density near the lunar surface were conducted during the SELENE (Kaguya) mission using the Vstar and Rstar sub-satellites. Previous radio occultation measurements conducted in the Soviet lunar missions have indicated the existence of an ionosphere with peak densities of several hundreds of electrons per cubic centimeters above the dayside lunar surface. These densities are difficult to explain theoretically when the removal of plasma by the solar wind is considered, and thus the generation mechanism of the lunar ionosphere is a major issue, with even the validity of previous observations still under debate. The most serious error source in the measurement is the fluctuation of the terrestrial ionosphere which also exists along the ray path. To cope with this difficulty, about 400 observations were conducted using Vstar to enable statistical analysis of the weak signal of the lunar ionosphere. Another method is to utilize Vstar and Rstar with the second one being used to measure the terrestrial ionosphere contribution. The observations will establish the morphology of the lunar ionosphere and will reveal its relationship with various conditions to provide possible clues to the mechanism.