DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

关于一维非定常气─固二相流特征理论的讨论

本文研究了一维非定常气－团二相流的特征，对于目前常用的、包含一定近似的运动方程组，它有两个虚部很小的复根，研究表明这种很小的虚部出现与方程中引入的近似有关。从十多个算例的结果看，这样的虚部不影响人们在工程计算中用该方程组求解初值问题。针对具有上述特征的气－团二相流方程组，本文发展了一种类特征线方法，它保留了双曲型方程特征线方法的若干优点，但它允许方程的特征根中有微小的虚部。含灰气体激波管流动的计算表明，类特征线法具有精度高、数值耗散和弥散小等优点     

绝对不稳定性理论在尾流稳定性分析方面的研究

介绍了绝对／对流不稳定性的理论框架，并应用于钝体尾流剪切层的稳定性分析研究中。钝体尾流可以认为是局部平行流，而局部平行流的稳定性分析可以归结为Ｏｒｒ－Ｓｏｍｍｅｒｆｅｌｄ方程的求解。Ｏ－Ｓ方程求解化为一个复广义矩阵问题ＡＸ＝ωＢＸ，并分别约化Ａ，Ｂ为上Ｈｅｓｓｅｎｂｅｒｇ阵和上三角阵，通过Ｃｈｅｂｙｓｈｅｖ配置法可以求出特征值。最后对于Ｇａｕｓｓ尾流计算模型，给出了其在不同Ｒｅｙｎｏｌｄｓ下，流动     

准各向同性基层上椭圆形子层的屈曲

通过改进文献[1]中假设的挠度函数,使Rayleigh-Ritz法能用于计算准各向同性基层上任意对称椭圆形子层的临界应变,然后以单向层板为主,探讨了临界应变随基层泊桑比ν,椭圆半轴之比λ,子层角θ和单层铺设角α的变化规律。     

对策论在雷达电子战效能评估中的应用

介绍了对策论的基本内容和分析方法,包括对策论所涉及问题的要素和分类.指出了对策论在雷达电子战效能评估中应用的可行性和必要性.分析了电子对抗博弈双方采取不同对抗技术措施的得益矩阵,并在此得益矩阵的基础上,重点研究了对策论在电子对抗效能评估过程中的应用.     

企业标准体系的建立与完善及对策

介绍企业标准体系的基本构成、特征和建立的原则,就建立完善的企业技术标准体系、制定企业管理标准体系和工作标准等阐述体系建立的途径,并对企业标准体系的管理、完善和改进等有关的几个问题进行探讨。     

减压活门性能试验台系统方案设计

主要介绍了减压活门性能试验台的实现机理、采用的方案。     

Application of Gram-Schmidt algorithm to fully adaptive arrays

The Gram-Schmidt orthogonalization (GSO) algorithm has excellent numerical performance and is readily applicable to systolic implementations such as in a field of adaptive cancellation systems. A modified GSO algorithm for a fully adaptive array is proposed and computer simulations show that the proposed algorithm gives superior performance. A systolic implementation of the proposed GSO algorithm for fully adaptive array is presented. A feedback mode GSO algorithm for use with analog weights is also presented and has been shown to have excellent performance in the presence of weight errors     

数控车削加工仿真系统结构研究

根据实际加工情况提出了一种虚拟NC车削加工的仿真系统的设计及实现原理。在Visual C++平台上利用OpenGL技术建立虚拟加工机床数字化模型,用C++语言实现物理仿真相关的各个数学模型的建立,进行虚拟环境下数控车削加工的几何仿真及物理仿真,实现产品的虚拟车削制造。     

INITIALIZATION METHODS FOR GROUP TRACKING

ＩＮＩＴＩＡＬＩＺＡＴＩＯＮＭＥＴＨＯＤＳＦＯＲＧＲＯＵＰＴＲＡＣＫＩＮＧＹａｎｇＣｈｅｕｇｙａｎｇ；ＱｕＪｉａｎｍｉｎｇ；ＭａｏＳｈｉｙｉ（ＢｅｉｊｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＡｅｒｏｎａｕｔｉｃｓａｎｄＡｓｔｒｏｎａｕｔｉｃｓ，Ｂｅｉｊｎｇ，Ｃ...