Biochemical constraints for survival under Martian conditions.

A wide variety of terrestrial organisms, the so-called "anhydrobiotes," has learned to survive in a state of extreme dehydration in dry environments. Strategies for survival include the accumulation of certain polyols and nonreducing saccharides, which help to prevent damage to membranes and proteins, but at low water partial pressure DNA is also progressively damaged by various lesions, including strand breaks and cross-linking to proteins. These lesions, if they are not too numerous, can be repaired before the first replication step after rehydration, but long-term exposure to dry conditions finally diminishes the chances of survival as these lesions accumulate. If an organism has no chance to repair the accumulated DNA damage during intermittent periods of active life, survival will not exceed a few decades. The restriction of survival by dryness-induced DNA lesions is corroborated by new data on conidia of Aspergillus and the free plasmid pBR 322. Our results will be discussed with respect to the chance of finding dormant life or biochemical fossils on the surface of Mars.     

Leg venous hemodynamics and leg volumes during a 42 day -6 degrees head-down bedrest

Seven healthy subjects were submitted to a 42-day head down bedrest, where leg venous compliance (venous distensibity index VDI) and leg volumes were assessed by mercury strain gauge plethysmography with venous occlusion and optoelectronic plethysmography, respectively. Plethysmographic and volometric measurements were made, before, during (at days 1, 4, 7, 14, 21, 26, 34 and 41), and after bedrest (days 1, 4, 7, 11 and 30 of the recovery period). Results showed a continuous decrease in leg volumes throughout bedrest, when VDI increased until day 26 of bedrest, and then decreased afterwards. The recovery period was characterized by a rapid return of VDI to prebedrest levels while leg volumes progressively normalised. These results showed that leg venous compliance changes are not always dependant upon skeletal muscle changes, and that factors other than size of muscle compartment are able to determine increases in leg venous compliance during long-term bedrest.     

Spatial orientation during locomotion [correction of locomation] following space flight

To investigate changes in spatial orientation ability and walking performance following space flight, 7 astronaut subjects were asked pre- and post-flight to perform a goal directed locomotion paradigm which consisted of walking a triangular path with and without vision. This new paradigm, involving inputs from different sensory systems, allows quantification of several critical parameters, like orientation performance, walking velocities and postural stability, in a natural walking task. The paper presented here mainly focusses on spatial orientation performance quantified by the errors in walking the previously seen path without vision. Errors in length and reaching the corners did not change significantly from pre- to post-flight, while absolute angular errors slightly increased post-flight. The significant decrease in walking velocity and a change in head-trunk coordination while walking around the corners of the path observed post-flight may suggest that during re-adaptation to gravity the mechanisms which are necessary to perform the task have to be re-accomplished.     

The effect of head-down tilt on brain potentials related to visual attention

To study the possible effect of simulated weightlessness on brain function state, the brain event-related potentials (ERPs) in a simple visual selective response task were compared between HDT and HUT in 9 normal subjects. The results were: The Target(T) and non-Target(NT) flash signals both induced significant slow positive potentials which were supposed to related to the attention state; the amplitude of the positive potentials in frontal regions decreased significantly especially for NT-ERPs during HDT comprared with that during HUT. The data reported provide new evidence indicating that more attention should be paid on the brain function study during space flight.     

On the correlation between individual biochemical parameters of human blood serum following space flight and their basal values

The article presents data concerning the osmolality and concentration of electrolytes and hormones regulating their balance for blood serum of 223 cosmonauts and astronauts. The obtained results allow us to judge the constancy of physicochemical parameters for the blood serum of healthy individuals and how they react to extreme conditions of space flight. The parameters used for evaluation included not just absolute values for the examined indices, but also how they responded to space flight, the dependence on baseline values and the interrelationship between ions. These data are important to predict the effect of exposure to extreme conditions and point to what extent the effect depends on the characteristics of the individual.     

Effect of potassium and calcium loading on healthy subjects under hypokinesia and physical exercise with fluid and salt supplements

The objective of this investigation was to determine the acute responses to the electrolyte challenges under hypokinesia and physical exercise (PE) of different intensities with fluid and salt supplementation (FSS). The studies were performed on 12 physically healthy male volunteers aged 19-24 years under 364 days of hypokinesia (decreased number of steps per day) with a set of PE with FSS. The volunteers were divided into two equal groups. The first group was subjected to a set of intensive PE and the second group was submitted to a set of moderate PE. Both groups of subjects consumed daily water and salt supplements that aimed to increase the body hydration level. For simulation of the hypokinetic effect all subjects were kept under an average of 3000 steps per day. Functional tests with a potassium chloride (KCl) and calcium lactate (Cal) load were performed during the hypokinetic period of 364 days and the 60-day, prehypokinetic period that served as control, while both groups of subjects consumed daily calcium and potassium supplements. The concentration of electrolyte and hormone levels in the blood and their excretion rate in urine were determined. Renal excretion of calcium and potassium and the blood concentration thereof increased markedly in both groups of subjects. With the potassium chloride load tests the increased potassium excretion was accompanied by higher aldosterone and insulin blood levels, and with the calcium lactate load tests the increased calcium excretion was accompanied by a decreased parathyroid content in the blood. FSS and PE, regardless of intensity, failed to attenuate calcium and potassium losses. Additional intake of KCl and Cal also failed to normalize potassium and calcium abnormalities. It was concluded that during the KCl and Cal loading tests, the increased losses of potassium and calcium in the hypokinetic subjects were due to the inability of their bodies to retain these electrolytes, and that electrolyte abnormalities could not be reversed by PE or rehydration in individuals subjected to prolonged restriction of motor activity.     

Cosmic ray modulation in the 3-D heliosphere

The basic physical processes that lead to the long-term modulation of cosmic rays by the solar wind have been known for many years. However our knowledge of the structure of the heliosphere, which determines which processes are most important for the modulation, and of the variation of this structure with time and solar activity level is still incomplete. Study of the modulation provides a tool for probing the scale and structure of the heliosphere. While the Pioneer and Voyager spacecraft are surveying the radial structure and extent of the heliosphere at modest heliographic latitudes, theUlysses mission is the first to undertake a nearly complete scan of the latitudinal structure of the modulated cosmic ray intensity in the inner heliosphere (R<5.4 AU).Ulysses will reach latitudes of 80°S in September 1994 and 80°N in July 1995 during the approach to minimum activity in the 11 year solar cycle. We present a first report of measurements extending to latitudes of 52°S, which show surprisingly little latitudinal effect in the modulated intensities and suggest that at this time modulation in the inner heliosphere may be much more spherically symmetric than had generally been believed based upon models and previous observations.     

Tracking multiple objects with particle filtering

We address the problem of multitarget tracking (MTT) encountered in many situations in signal or image processing. We consider stochastic dynamic systems detected by observation processes. The difficulty lies in the fact that the estimation of the states requires the assignment of the observations to the multiple targets. We propose an extension of the classical particle filter where the stochastic vector of assignment is estimated by a Gibbs sampler. This algorithm is used to estimate the trajectories of multiple targets from their noisy bearings, thus showing its ability to solve the data association problem. Moreover this algorithm is easily extended to multireceiver observations where the receivers can produce measurements of various nature with different frequencies.     

Comparison of two measurement fusion methods forKalman-filter-based multisensor data fusion

Currently there exist two commonly used measurement fusion methods for Kalman-filter-based multisensor data fusion. The first (Method I) simply merges the multisensor data through the observation vector of the Kalman filter, whereas the second (Method II) combines the multisensor data based on a minimum-mean-square-error criterion. This paper, based on an analysis of the fused state estimate covariances of the two measurement fusion methods, shows that the two measurement fusion methods are functionally equivalent if the sensors used for data fusion, with different and independent noise characteristics, have identical measurement matrices. Also presented are simulation results on state estimation using the two measurement fusion methods, followed by the analysis of the computational advantages of each method     

C/SiC复合材料超声振动钻孔评估

在分析碳纤维增强碳化硅复合材料的力学性能、密度、孔隙率和弯曲强度的基础上 ,进行了超声钻孔工艺试验 ,检测并研究了材料去除率、孔径差、孔边质量和工具损耗情况 ,得出了超声钻孔是一种好的加工方法的结论。