Reflections on the quest for international cooperation

Changed political objectives, straitened economic circumstances and an altered balance of capability and expertise in space endeavours have together produced more discussion of the need for international cooperation than ever before, but the meaning of the term has subtly shifted. Insisting on US ‘leadership’ is self-defeating; what is instead firmly desired by the USA's potential partners is a balanced relationship in which each nation makes an identifiable contribution and takes the lead in at least one of a package of projects. If this is going to happen, there must be an international forum or framework in which projects can be discussed and agreed. This in turn requires initiative at governmental level.     

Cytogenetic effects of energetic ions with shielding

In order to understand the effects of shielding on the induction of biological damages by charged particles, we conducted experiments with accelerated protons (250 MeV) and iron particles (1 GeV/u). Human lymphocytes in vitro were exposed to particle beams through polyethylene with various thickness, and chromosomal aberrations were determined using FISH technique. Dose response curves for chromosome aberrations were obtained and compared for various particle types. Experimental results indicated that for a given absorbed dose at the cell, the effectiveness of protons and iron particles in the induction of chromosomal aberrations was not significantly altered by polyethylene with thickness up to 30-cm and 15-cm respectively. Comparing with gamma rays, charged particles were very effective in producing complex chromosomal damages, which may be an important mechanism in alterating functions in nondividing tissues, such as nervous systems.     

Microsatellite instability in human mammary epithelial cells transformed by heavy ions

We analyzed DNA and proteins obtained from normal and transformed human mammary epithelial cells for studying the neoplastic transformation by high-LET irradiation in vitro. We also examined microsatellite instability in human mammary cells transformed to various stages of carcinogenesis, such as normal, growth variant and tumorigenic, using microsatellite marker D5S177 on the chromosome 5 and CY17 on the Chromosome 10. Microsatellite instabilities were detected in the tumorigenic stage. These results suggest that microsatellite instability may play a role in the progression of tumorigenecity. The cause of the genomic instability has been suggested as abnormalities of DNA-repair systems which may be due to one of the three reasons: 1) alterations of cell cycle regulating genes. 2) mutations in any of the DNA mismatch repair genes. 3) mutation in any of the DNA strand breaks repair genes. No abnormality of these genes and encoded proteins, however was found in the present studies. These studies thus suggest that the microsatellite instability is induced by an alternative mechanism.     

Neutral H Density at the Termination Shock: A Consolidation of Recent Results

We discuss a consolidation of determinations of the density of neutral interstellar H at the nose of the termination shock carried out with the use of various data sets, techniques, and modeling approaches. In particular, we focus on the determination of this density based on observations of H pickup ions on Ulysses during its aphelion passage through the ecliptic plane. We discuss in greater detail a novel method of determination of the density from these measurements and review the results from its application to actual data. The H density at TS derived from this analysis is equal to 0.087±0.022 cm^?3, and when all relevant determinations are taken into account, the consolidated density is obtained at 0.09±0.022 cm^?3. The density of H in CHISM based on literature values of filtration factor is then calculated at 0.16±0.04 cm^?3.     

Moon first versus flexible path exploration strategies: Considering international contributions

This paper analyses potential future collaborative space exploration architectures in terms of 1) the technical capabilities of contributing partners; and 2) the constraints imposed by internal and international politics. We find that when international partners are considered endogenously, the argument for a “flexible path” approach is weakened substantially. This is because international contributions can make “Moon first” economically feasible; and characteristics of proposed “flexible path” approaches may preclude international involvement because of the disproportionate risk that those contributions inherently bear. This could have serious implications for future collaborations. We also note that while there are multiple feasible collaborative architectures, there is currently substantial overlap among the potential niche contributions identified by the international partners.     

The Origin of Primary Cosmic Rays: Constraints from ACE Elemental and Isotopic Composition Observations

Cosmic-ray isotope observations from NASAs Advanced Composition Explorer (ACE) mission have been used to investigate the composition of cosmic-ray source material. Source abundances relative to ⁵⁶Fe are reported for eleven isotopes of Ca, Fe, Co, and Ni, including the very rare isotopes ⁴⁸Ca and ⁶⁴Ni. Although the source abundances range over a factor 10⁴, most of the ratios to ⁵⁶Fe are consistent with solar-system values to within 20%. However, there are some notable differences, the most significant being an excess of (70±30)% relative to the solar system for the cosmic-ray source ratio ⁵⁸Fe/⁵⁶Fe. The possible association of such an excess with a contribution to the cosmic-ray source from Wolf–Rayet star ejecta is discussed.     

M-FISH analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro.

Confluent human fibroblast cells were exposed to 6 Gy gamma-rays or 200 MeV/nucleon Fe ions at 0.7 or 3 Gy. The cells were allowed to repair for 24 hours after exposure and chromosomes were collected using a premature chromosome condensation technique with calyculin-A. Chromosome aberrations were analyzed using the multicolor FISH (mFISH) technique that allows identification of both complex and truly incomplete exchanges. Results showed that both doses of the Fe ions produced higher ratios of complex to simple exchanges and lower ratio of complete to incomplete exchanges than the 6 Gy gamma-exposure. The ratios of aberration yields were similar for the two doses of Fe ions. After 0.7 Gy of Fe ions, most complex aberrations were found to involve three or four chromosomes, indicating this is the maximum number of chromosome domains traversed by a single Fe ion track.     

The composition of heavy ions in solar energetic particle events

We review recent advances in determining the elemental, charge-state, and isotopic composition of 1 to 20 MeV per nucleon ions in solar energetic particle (SEP) events and outline our current understanding of the nature of solar and interplanetary processes which may explain the observations.The composition within individual SEP events may vary both with time and energy, and will in general be different from that in other SEP events. Average values of relative abundances measured in a large number of SEP events, however, are found to be roughly energy independent in the 1 to 20 MeV per nucleon range, and show a systematic deviation from photospheric abundances which seems to be organized in terms of the first ionization potential of the ion.Direct measurements of the charge states of SEPs have revealed the surprisingly common presence of energetic He⁺ along with heavy ions with typically coronal ionization states. High-resolution measurements of isotopic abundance ratios in a small number of SEP events show these to be consistent with the universal composition except for the puzzling overabundance of the SEP ²²Ne/²⁰Ne relative to this isotopes ratio in the solar wind. The broad spectrum of observed elemental abundance variations, which in their extreme result in composition anomalies characteristic of ³He-rich, heavy-ion rich and carbon-poor SEP events, along with direct measurements of the ionization states of SEPs provide essential information on the physical characteristics of, and conditions in the source regions, as well as important constraints to possible models for SEP production.It is concluded that SEP acceleration is a two-step process, beginning with plasma-wave heating of the ambient plasma in the lower corona, which may include pockets of cold material, and followed by acceleration to the observed energies by either flare-generated coronal shocks or Fermi-type processes in the corona. Interplanetary propagation as well as acceleration by interplanetary propagating shock will often further modify the composition of SEP events, especially at lower energies.