Dysfunctions of Spatial Cognition in Schizophrenic Patients

ABSTRACT

Twenty outpatients who fulfilled the criteria for a diagnosis of schizophrenia and 28 control participants were invited to learn a route through a complex outdoor environment. They were then tested in tasks intended to explore various aspects of their memorized representation of the navigational episode. Compared to controls, the patients showed significant impairment in both the verbal production of route directions and the drawing of sketch maps. They referred to fewer landmarks and provided fewer directional instructions than the controls, while making a greater number of irrelevant comments. When invited to distinguish between photographs showing views of landmarks encountered along the route and distractors, they performed as well as the controls, and they had similar response times. However, when they were presented with pairs of actual photographs taken along the route, they displayed special difficulty in deciding which of the two landmarks was encountered first along the route. This difficulty in retrieving the sequential structure of the navigational episode suggests that the patients' memories were not accurately linked to one another in their mental representation of the route. These findings are interpreted in the context of current hypotheses about the hippocampal impairment that affects schizophrenic patients.     

An alternative approach to solar system exploration planning

Planning for the future exploration of the solar system has involved the structuring of a series of missions that address major scientific objectives at a minimum runout cost for the entire endeavor. In many cases, however, the optimal structuring of a program that would minimize the runout cost would entail an unacceptable high annual funding. Our actual planning must consider the planning wedge imposed on the National Aeronautics and Space Administration. It is vital that a plan be structured that copes with the annual restraint. If we do not recognize this, our plan will not be realized and a queing problem will result, thus negating all of our planning efforts.This paper presents ideas as to how planetary initiatives can be structured, wherein the peak annual funding is minimized. One vital aspect in the plan is to have a transportation capability that can launch a mission in any planetary opportunity. Solar electric propulsion can provide this capability. Another cost reduction approach would be to structure a mission set in a time sequenced fashion that could utilize essentially the same spacecraft for the implementation of several missions. This opportunity does exist. A third technique would be to fulfill a scientific objective in several sequential missions rather than attempt to accomplish all of the objectives with one mission. This approach might be applied to a mission currently in the planning stage designated the Saturn Orbiter Dual Probe mission. The current concept involves the delivery of a Saturn probe, a Titan probe, and a Saturn Orbiter by a one Shuttle launch. In this case, the orbiter must serve as a relay station for both probes; map the magnetosphere of Saturn; conduct a survey of Saturn's major satellites; and perform the planetological observation of Saturn itself. This mission entails the development of a complex spacecraft that would be required to have a fairly long life due to the extended mission operations at the benefit of accomplishing the mission with one launch. An alternate approach would be to break the mission into two separate elements. We could, for example, launch a Saturn orbiter carrying a Saturn entry probe. After serving as a communications relay system for the Saturn probe, the orbiter would then be specialized to map the magnetosphere of Saturn. A second launch would involve the delivery of a Titan probe by another orbiter where after delivery the orbiter would conduct the planetological observation of Saturn and its satellites. For the split-launch option, the runout cost for the two missions would be greater than the single launch option. However, optimum structuring of the two missions could materially reduce the peak annual funding.This paper presents data on the estimated cost on a year by year basis of a mission set structured to minimize the runout cost with no concern as to the peak annual funding as compared to a mission set that would yield the same scientific objectives in a slightly longer time span wherein the annual peak funding would be minimized. The consequences of this revised plan are analyzed.     

Microgravity effects on Drosophila melanogaster development and aging: comparative analysis of the results of the Fly experiment in the Biokosmos 9 biosatellite flight.

The results are presented of the exposure of Drosophila melanogaster to microgravity conditions during a 15-day biosatellite flight, Biokosmos 9, in a joint ESA-URSS project. The experimental containers were loaded before launch with a set of Drosophila melanogaster Oregon R larvae so that imagoes were due to emerge half-way through the flight. A large number of normally developed larvae were recovered from the space-flown containers. These larvae were able to develop into normal adults confirming earlier results that Drosophila melanogaster of a wild-type constitution can develop normally in the absence of gravity. However, microgravity exposure clearly enhances the number of growing embryos laid by the flies and possibly slows down the developmental pace of the microgravity-exposed animals. Due to some problems in the experimental set-up, this slowing down needs to be verified in future experiments. No live adult that had been exposed to microgravity was recovered from the experiment, so that no life span studies could be carried out, but adult males emerged from the recovered embyros showed a slight shortening in life span and a lower performance in other experimental tests of aging. This agrees with the results of previous experiments performed by our groups.     

The Emirates Mars Mission (EMM) Emirates Mars InfraRed Spectrometer (EMIRS) Instrument

Space Science Reviews - Modern observatories have revealed the ubiquitous presence of magnetohydrodynamic waves in the solar corona. The propagating waves (in contrast to the standing waves) are...     

Digital Electronics Where We are and Where We are Going

The paper synopsizes the current situation with regard to the nature of the red as well as the blue-grey forces as their capabilities impact future avionics systems. The paper describes today's climate as it relates to the avionics posture of the current and future fighter air forces, congressional desires and budgetary direction. The paper describes the current US Air Force response in the terms of modular systems. The benefits of modular avionics systems are delineated and the impact of software on this new hardware approach are explained. The way to the future is postulated in terms of the threat versus force posturing and the impact on both today's and future weapons systems. The paper concludes with several recommendations which, while they will somewhat alter traditional industrial relationships, will also address the future avionics needs of the US Armed Force.     

Iron meteorites can support the growth of acidophilic chemolithoautotrophic microorganisms

Chemolithoautotrophy based on reduced inorganic minerals is considered a primitive energy transduction system. Evidence that a high number of meteorites crashed into the planet during the early period of Earth history led us to test the ability of iron-oxidizing bacteria to grow using iron meteorites as their source of energy. Here we report the growth of two acidophilic iron-oxidizing bacteria, Leptospirillum ferrooxidans and Acidithiobacillus ferrooxidans, on a piece of the Toluca meteorite as the only source of energy. The alteration of the surface of the exposed piece of meteorite, the solubilization of its oxidized metal constituents, mainly ferric iron, and the formation of goethite precipitates all clearly indicate that iron-meteorite-based chemolithotrophic metabolism is viable.     

Insects as test systems for assessing the potential role of microgravity in biological development and evolution.

Gravity and radiation are undoubtedly the two major environmental factors altered in space. Gravity is a weak force, which creates a permanent potential field acting on the mass of biological systems and their cellular components, strongly reduced in space flights. Developmental systems, particularly at very early stages, provide the larger cellular compartments known, where the effects of alterations in the size of the gravity vector on living organisms can be more effectively tested. The insects, one of the more highly evolved classes of animals in which early development occurs in a syncytial embryo, are systems particularly well suited to test these effects and the specific developmental mechanisms affected. Furthermore, they share some basic features such as small size, short life cycles, relatively high radio-resistance, etc. and show a diversity of developmental strategies and tempos advantageous in experiments of this type in space. Drosophila melanogaster, the current biological paradigm to study development, with so much genetic and evolutionary background available, is clearly the reference organism for these studies. The current evidence on the effects of the physical parameters altered in space flights on insect development indicate a surprising correlation between effects seen on the fast developing and relatively small Drosophila embryo and the more slowly developing and large Carausius morosus system. In relation to the issue of the importance of developmental and environmental constraints in biological evolution, still the missing link in current evolutionary thinking, insects and space facilities for long-term experiments could provide useful experimental settings where to critically assess how development and evolution may be interconnected. Finally, it has to be pointed out that since there are experimental data indicating a possible synergism between microgravity and space radiation, possible effects of space radiation should be taken into account in the planning and evaluation of experiments designed to test the potential role of microgravity on biological developmental and evolution.     

A General Solution for the Shortest Acquisition Time in Type-II Phase-Lock Loops

A general solution to the synthesis of an optimum control that minimizes the acquisition time in type-II phase-lock loops is presented. The result is applied to a loop with a sinusoidal phase detector and to a loop with a multilinear phase detector.