A mathematical and experimental simulation of the hematological response to weightlessness

Two ground-based methods of weightlessness simulation--a computer model of erythropoiesis feedback regulation and bedrest--were used to investigate the mechanisms which lead to loss of red cell mass during spaceflight. Both methods were used to simulate the first Skylab mission of 28 days. Human bedrest subjects lose red cell mass linearly with time and in this study the loss was 6.7% at the end of four weeks (compared to 14% in Skylab). Postbedrest recovery of red cell mass was delayed for two weeks during which time a further decline in this quantity was noted. This is consistent with the first Skylab mission but not with the two longer flights of two and three months. Hemoconcentration, observed early in the study, was essentially maintained despite red cell loss because of continued loss of plasma volume. The computer model, using the time-varying hematocrit data to estimate red cell production rates, predicted dynamic behavior of plasma volume and red cell mass that was in close agreement with the measured values. The results support the hypothesis that red cell loss during supine bedrest is a normal physiological feedback process in response to hemoconcentration enhanced tissue oxygenation and suppression of red cell production. In contrast, the delayed postbedrest recovery of red cell mass was more difficult to explain, especially in the light of enhanced reticulocyte indices observed at the onset on ambulation. Model simulation suggested the possibilities, still to be experimentally demonstrated, that this period was marked by some combination of increased oxygen-hemoglobin affinity, small reductions in mean red cell life span, ineffective erythropoiesis, or abnormal reticulocytosis. The question of whether hemoconcentration is the sole contributor to spaceflight red cell losses also remains to be resolved.     

Potential cost reductions for three STS/Spacelab mission modes

Based on the results of studies carried out by ESA several possibilities are discussed to achieve mission cost reductions for large Spacelab instrument facilities as compared to their flight on several 7-day duration Spacelab missions. As an example three scientific telescope facilities are selected (LIRTS, EXSPOS, GRIST) which are defined to a Phase A level.Three new mission modes are considered:

• —Shuttle attached Spacelab mission mode with extended flight duration (up to 30 days) for which the application of planned capability extensions and new elements of the STS/Spacelab (e.g. Short Spacelab Pallets, Power Extension Package) are investigated.

• —Shuttle deployed mission mode, for which the telescope, accommodated on a Spacelab pallet, is docked to the Power Module, a new element of the Space Transportation System under study by NASA.

• —Free-flying mission mode, for which Shuttle launched dedicated missions of the facilities are considered, assuming varying degrees of autonomy with respect to supporting services of the Shuttle.

Reduction of costs have been considered on the levels of single mission cost and total programme cost. Fundamentally the charges for the instrument can be reduced by constraining the mass/volume factors with respect to the Shuttle capability. However, the instrument as part of a payload is only viable if an acceptable resource sharing including observation time can be achieved. Any single instrument will require several mission opportunities or one mission which achieves a similar or longer total observation programme.Based on an identification of instrument modifications of the Phase A baseline designs to favour cost reductions and on a derivation of technical requirements, constraints and finally budgetary cost comparisons an attempt is made to assess the advantages and disadvantages of the different mission modes.The favoured option for GRIST is a 2–3 weeks sortie mission followed after refurbishment by a longer Power Module docked mission. For LIRTS and EXSPOS the free-flying pallet modes are very attractive in terms of the longer durations achieved and in terms of cost per unit operating time.     

Skylab experiment M-092: results of the first manned mission

Blood pressure at 30-sec intervals, heart rate, and percentage increase in leg volume continuously were recorded during a 25-min protocol in the M092 Inflight Lower Body Negative Pressure (LBNP) experiment carried out in the first manned Skylab mission. These data were collected during six tests on each crewman over a 5-month preflight period. The protocol consisted of a 5-min resting control period, 1 min at -8, 1 min at -16, 3 min at -30, 5 min at -40, and 5 min at -50 mm Hg LBNP. A 5-min recovery period followed. Inflight tests were performed at approximately 3-day intervals through the 28-day mission. Individual variations in cardiovascular responses to LBNP during the preflight period continued to be demonstrated in the inflight tests. Measurements of the calf indicated that a large volume of fluid was shifted out of the legs early in the flight and that a slower decrease in leg volume, presumably due to loss of muscle tissue, continued throughout the flight. Resting heart rates tended to be low early in the flight and to increase slightly as the flight progressed. Resting blood pressure varied but usually was characterized by slightly elevated systolic blood pressure, lower diastolic pressure, and higher pulse pressures than during preflight examinations. During LBNP inflight a much greater increase in leg volume occurred than in preflight tests. Large increases occurred even at the smallest levels of negative pressure, suggesting that the veins of the legs were relatively empty at the beginning of the LBNP. The greater volume of blood pooled in the legs was associated with greater increases of heart rate and diastolic pressure and larger falls of systolic and pulse pressure than seen in preflight tests. The LBNP protocol represented a greater stress inflight, and on three occasions it was necessary to stop the test early because of impending syncopal reactions. LBNP responses inflight appeared to predict the degree of postflight orthostatic intolerance. Postflight responses to LBNP during the first 48 hours were characterized by marked elevations of heart rate and instability of blood pressure. In addition, systolic and diastolic pressures were typically elevated considerably both at rest and also during stress. The time required for cardiovascular responses to return to preflight levels was much slower than in the case of Apollo crewmen.     

Short profile for the human spacecraft Soyuz-TMA rendezvous mission to the ISS

Reduction of flight duration after insertion till docking to the ISS is considered. In the beginning of the human flight era both the USSR and the USA used short mission profiles due to limited life support resources. A rendezvous during these missions was usually achieved in 1–5 revolutions. The short-term rendezvous were made possible by the coordinated launch profiles of both rendezvousing spacecraft, which provided specific relative position of the spacecraft or phase angle conditions. After the beginning of regular flights to the orbital stations these requirements became difficult to fulfill. That is why it was decided to transfer to 1- or 2-day rendezvous profile. The long stay of a crew in a limited habitation volume of the Soyuz-TMA spacecraft before docking to the ISS is one of the most strained parts of the flight and naturally cosmonauts wish to dock to the ISS as soon as possible. As a result of previous studies the short four-burn rendezvous mission profile with docking in a few orbits was developed. It is shown that the current capabilities of the Soyuz-FG launch vehicle and the Soyuz-TMA spacecraft are sufficient to provide for that. The first test of the short rendezvous mission during Progress cargo vehicle flight to the ISS is planned for 2012. Possible contingencies pertinent to this profile are described. In particular, in the majority of the emergency cases there is a possibility of an urgent transfer to the present 2-day rendezvous profile. Thus, the short mission will be very flexible and will not influence the ISS mission plan. Fuel consumption for the nominal and emergency cases is defined by statistical simulation of the rendezvous mission. The qualitative analysis of the short-term and current 2-day rendezvous missions is performed.     

木星辐射环境不确定性对总剂量风险的影响

以木星探测任务为背景，针对木星辐射带粒子能量高、通量大的强辐射特点，基于器件总剂量辐照试验数据、木星辐射带模型、太阳质子通量模型，将器件失效点剂量不确定性与辐射环境不确定性应用到总剂量设计中，可定量评估特定任务一定屏蔽下的器件失效概率、辐射设计余量(RDM)的置信度及影响因素，可实现木星任务中器件指标、屏蔽厚度和失效概率之间的权衡和优化。首先，根据商业器件TL084辐照试验数据，发现其失效概率分布符合威布尔分布。对于10个木星半径的赤道面轨道，辐射带质子通量比太阳质子大3个数量级，随着屏蔽厚度的增加和任务期的减小，TL084器件所受剂量和失效概率减小。当屏蔽厚度为 10 mm 铝时，器件平均寿命小于2星期。另外，定义并考察了器件的失效速率，失效速率随屏蔽厚度的减小和在轨时间的增加而增加。对于传统的RDM为2的设计方法，1 mm铝屏蔽下对应的置信度为89%。     

Fluid volumes changes induced by spaceflight

The blood volume (BV), plasma volume (PV), and extracellular fluid volume changes produced in crewmembers during spaceflights of 11-84 days were compared to changes after 14 or 28 days of bedrest. Spaceflight and bedrest produce approximately equal BV changes but the recorded PV change after spaceflight was less. However, the diurnal change in PV may explain the smaller decreases recorded after spaceflight. The cardiovascular deconditioning caused by spaceflight and bedrest was compared using the mean heart rate response to lower body negative pressure (LBNP) testing at -50 mmHg pressure. These tests show approximately equal LBNP produced heart rate changes after bedrest and spaceflight. A countermeasure which includes 4 hr of LBNP treatment at -30 mmHg and the ingestion of one l. of saline was studied and found capable of returning the heart rate response and the PV of bedrested subjects to control (prebedrest) levels suggesting that it would be useful to the crewmembers after a spaceflight.     

Hematological and immunological changes during space flight.

This paper gives a summary of the principal hematological and immunological changes observed in crews after space flight. Reduction of red blood cell mass (2-21%) and of hemoglobin mass (12-33%) is generally observed after the US and Soviet space missions. The changes are accompanied with a loss of plasma volume (4-16%). Erythrocyte and hemoglobin concentrations in the blood remain constant, suggesting that the changes are driven by a feed-back mechanism. Immunological changes consist mainly of reduced T-lymphocyte reactivity. The results of the 96-day and 140-day Salyut-6 missions suggest that the adaptation of the immune system to spaceflight occurs in two stages: the first takes place during the first 2-3 months in space, the second follows and consists of further weakening of the immune response. Our experiments with human lymphocytes in vitro indicate that high-g enhance, whereas low-g depress lymphocyte activity. Finally, our investigations to be performed on Spacelab are described.     

Skylab experiment results: hematology studies

These studies were designed and coordinated to evaluate specific aspects of man's immunologic and hematologic systems which might be altered by or respond to the space flight environment. The biochemical functions investigated included cytogenetic damage to blood cells, immune resistance to disease, regulation of plasma and red cell volumes, metabolic processes of the red blood cell, and physical chemical aspects of red blood cell functions. Only minor changes were observed in the functional capacity of erythrocytes as determined by measuring the concentrations of selected intracellular enzymes and metabolites. Tests of red cell osmotic regulation indicated some elevation in the activity of the metabolic dependent Na-K pump, with no significant alterations in the cellular Na and K concentrations or osmotic fragility. A transient shift in red cell specific-gravity profile was observed on recovery, possibly related to changes in cellular water content. Measurements of hemoconcentration (hematocrit, hemoglobin concentration, red cell count) indicated significant fluctuations postflight, reflecting observed changes in red cell mass and plasma volume. There was no apparent reticulocytosis during the 18 days following the first manned Skylab mission in spite of a significant loss in red cell mass. However, the reticulocyte count and index did increase significantly 5 to 7 days after completion of the second, longer duration, flight. There were no significant changes in either the while blood cell count or differential. However, the capacity of lymphocytes to respond to an in vitro mitogenic challenge was repressed postflight, and appeared to be related to mission duration. The cause of this repression is unknown at this time. Only minor differences were observed in plasma protein patterns. In the second mission there were changes in the proteins involved in the coagulation process which suggested a hypercoagulative condition.     

空间闭式布雷顿循环旁路调节特性分析

闭式布雷顿循环是未来空间大功率热电转换的有效途径,而旁路调节是实现系统快速功率调节和转速控制的有效手段。通过对标美国普罗米修斯计划中的热电转换系统参数,进行了涡轮、压气机的气动设计和换热器性能计算,获得了包括组件特性、管道布局的热电转换系统动态仿真模型。基于该动态模型,对旁通阀不同响应时间、开度对系统功率、转速和循环温度、压力等参数影响进行仿真研究。空间闭式布雷顿循环系统在旁通阀开启后,系统功率和转速快速下降,其中功率出现了超调现象;循环高压侧压力下降且低压侧压力上升;回热器热侧入口温度增加而冷侧入口温度下降,热应力进一步提高。系统容积的提高,在一定程度上可以降低系统对旁通阀调节的敏感性。     

The endocrine system in space flight

Hormones are important effectors of the body's response to microgravity in the areas of fluid and electrolyte metabolism, erythropoiesis, and calcium metabolism. For many years antidiuretic hormone, cortisol and aldosterone have been considered the hormones most important for regulation of body fluid volume and blood levels of electrolytes, but they cannot account totally for losses of fluid and electrolytes during space flight. We have now measured atrial natriuretic factor (ANF), a hormone recently shown to regulate sodium and water excretion, in blood specimens obtained during flight. After 30 or 42 h of weightlessness, mean ANF was elevated. After 175 or 180 h, ANF had decreased by 59%, and it changed little between that time and soon after landing. There is probably an increase in ANF early inflight associated with the fluid shift, followed by a compensatory decrease in blood volume. Increased renal blood flow may cause the later ANF decrease. Erythropoietin (Ep), a hormone involved in the control of red blood cell production, was measured in blood samples taken during the first Spacelab mission and was significantly decreased on the second day of flight, suggesting also an increase in renal blood flow. Spacelab-2 investigators report that the active vitamin D metabolite 1 alpha, 25-dihydroxyvitamin D3 increased early in the flight, indicating that a stimulus for increased bone resorption occurs by 30 h after launch.     

Market-based approaches for controlling space mission costs: the Cassini Resource Exchange

Using economic incentives to control costs is a new concept for space missions. The basic tenets of market-based approaches run counter to typical centralized management techniques often utilized for complex space missions. NASA's Cassini mission to Saturn used a market trading system to assist the Science Instrument Manager in guiding the development of the spacecraft's science payload. This system allowed science instrument teams to trade resources among themselves to best manage their resources (mass, power, data rate, and budget). Thus, Cassini Project management was no longer responsible for adjudicating and reallocating resources that result from instrument development problems. Instrument teams were responsible for directly managing their resources and if they ran into a development problem it was their responsibility to resolve their problem by descoping or through the use of a 'resource exchange.' Under the trading system, instrument cost growth was less than 1% and the total payload mass was under its allocation by 7%. This result is in stark contrast to the 50%–100% increases in these resources on past missions.     

Respiratory mechanics after 180 days space mission (EUROMIR'95)

The present study reports data on respiratory function of lung and chest wall following the 180 days long European - Russian EuroMir '95 space mission. Data reported refer to two subjects studied before the mission, on day 9 and 175 in flight and on days 1, 10, 12, 27 and 120 after return. In-flight vital capacity (VC) and expiratory reserve volume (ERV) were similar to those in supine posture, namely approximately 5% and approximately 30% less than in sitting posture. On day 1 after return, VC was reduced by approximately 30% in both postures. This reflected a decrease in ERV (approximately 0.5 L) and in IC (inspiratory capacity, approximately 1.7 L) that could be attributed to a marked weakening of the respiratory muscles. Regain of normal preflight values barely occurred 120 days after return. Post-flight pressure-volume curves of the lung, chest wall and total respiratory system are equal to preflight ones. The pressure-volume curve of the lung in supine posture is displaced to the right relative to sitting posture and shows a lower compliance. As far as the lung in-flight condition resembles that occurring in supine posture, this implies a lower compliance, a greater amount of blood in the pulmonary microvascular bed, a more homogeneous lung perfusion and therefore a greater microvascular filtration rate towards lung interstitium.     

Effect on the cardiac function of repeated LBNP during a 1-month head down tilt

Cardiovascular assessment by ultrasound methods was performed during two long duration (1 month) Head Down Tilt (HDT) on 6 healthy volunteers. On a first 1 month HDT session, 3 of the 6 subjects (A, B, C) had daily several lower body negative pressure tests (LBNP), whereas the 3 subjects remaining (D, E, F) rested without LBNP. On a second 1 month HDT session subjects D, E, and F had daily LBNP tests and the A, B and C subjects did not. The cardiac function was assessed by Echocardiography, (B mode, TM mode). On all the "6 non LBNP" subjects the left ventricule diastolic volume (LVDV), the stroke volume (SV) and the cardiac output (CO) increase (+10%, -15%) after HDT then decrease and remain inferior (-5%, -5%) or equal to the basal value during the HDT. Immediately after the end of the HDT the heart rate (HR) increase (+10%, +30%) whereas the cardiac parameters decrease weakly (-5%, -10%) and normalize after 3 days of recovery. On the "6 LBNP" subjects the LVDV, SV and CO increase (+10%, 15%) after 1 h HDT as in the previous group then decrease but remain superior (+5%, +15%) or equal to the basal value. After the HDT session, the HR is markedly increased (+20%, +40%) the LVDV and SV decrease (-15%, -20%) whereas the CO increases or decreases depending on the amplitude of the HR variations. These parameters do not completely normalize after 3 day's recovery. Repeated LBNP sessions have a significant effect on the cardiovascular function as it maintains all cardiac parameters above the basal value. The LBNP manoeuvre can be considered as an efficient countermeasure to prevent cardiac disadaptation induced by HDT position and probably microgravity.     

Clinical effects of thigh cuffs during a 7-day 6 degrees head-down bed rest.

Thigh cuffs are used by Russian cosmonauts to limit the fluid shift induced by space flight. A ground simulation using the head-down bed rest (HDBR) model was performed to assess the effects of thigh cuffs on clinical tolerance and orthostatic adaptation. 8 male healthy volunteers (32.4 +/- 1.9 years) participated twice in a 7-day HDBR--one time with thigh cuffs (worn daily from 9 am to 7 pm) (TC) and one time without (WTC). Orthostatic tolerance was assessed by a 10 minute stand test and by a LBNP test (5 min at -15, -30, -45 mmHg) before (BDC-1) and at the end of the HDBR period (R+1). Plasma volume was measured before and at the end of HDBR by the Evans blue dye dilution technique. Thigh cuffs limits headache due to fluid shift, as well as the loss in plasma volume (TC: -5.85 +/- 0.95%; WTC: -9.09 +/- 0.82%, p<0.05). The mean duration of the stand test (R+1) did not differ in the two group (TC 7.1 +/- 1.3 min; WTC 7.0 +/- 1.0 min). The increase in HR and decrease in diastolic blood pressure were slightly but significantly larger without thigh cuffs. Duration of the LBNP tests did not differ with thigh cuffs. Thigh cuffs limit the symptoms due to fluid shift and the loss in plasma volume. They partly reduced the increase in HR during orthostatic stress but had no effect on duration of orthostatic stress tests.     

Blood volume regulating hormones, fluid and electrolyte modifications during 21 and 198-day space flights (Altair-MIR 1993)

During the Altair MIR' 93 mission we studied several parameters involved in blood volume regulation. The experiment was done on two cosmonauts before (B-60, B-30), during (D6, D12, D18 for French and D7, D12, D17 for Russian) and after the flight (R+1, R+3 and R+7). Space flight durations were different for two cosmonauts: for the Russian the flight duration was 198 days and for the French 21 days. On board the MIR station only urinary (volume and electrolytes, atrial natriuretic peptide (ANP), cyclic guanosine monophosphate (cGMP) and catecholamines) and salivary (cGMP and cortisol) samples were collected, centrifuged and stored in freezer. Lithium was used as a tracer to know exactly the 24 h urine output (CNES urine collection Kit). Before and after flight, blood was drawn with an epicite needle and vacutainer system for hormonal assays (renin, antidiuretic hormone, cGMP, ANP and aldosterone) in two positions: after 30 min rest in upright seated position and after 90 min of supine position. Salivary samples were collected simultaneously. During flight a decrease of diuresis and ANP and an increase of osmolality were found. No modifications of hematocrit, but an increase of salivary cGMP and cortisol were also observed. The decrease of urinary ANP is in favor of hypovolemia as described in previous flights. The postflight examinations revealed changes in fluid-electrolyte metabolism which indicate a hypohydration status and a stimulation of hormonal system responsible for water and electrolyte retention in order to readapt to the normal gravity.     

Leadership issues with multicultural crews on the international space station: lessons learned from Shuttle/Mir

In isolated and confined environments, two important leadership roles have been identified: the task/instrumental role (which focuses on work goals and operational needs), and the supportive/expressive role (which focuses on morale goals and emotional needs). On the International Space Station, the mission commander should be familiar with both of these aspects of leadership. In previous research involving a 135-day Mir space station simulation in Moscow and a series of on-orbit Mir space station missions during the Shuttle/Mir program, both these leadership roles were studied. In new analyses of the Shuttle/Mir data, we found that for crewmembers, the supportive role of the commander (but not the task role) related positively with crew cohesion. For mission control personnel on the ground, both the task and supportive roles of their leader were related positively to mission control cohesion. The implications of these findings are discussed in terms of leadership on board the International Space Station.     

Sleep and cognitive function of crewmembers and mission controllers working 24-h shifts during a simulated 105-day spaceflight mission

The success of long-duration space missions depends on the ability of crewmembers and mission support specialists to be alert and maintain high levels of cognitive function while operating complex, technical equipment. We examined sleep, nocturnal melatonin levels and cognitive function of crewmembers and the sleep and cognitive function of mission controllers who participated in a high-fidelity 105-day simulated spaceflight mission at the Institute of Biomedical Problems (Moscow). Crewmembers were required to perform daily mission duties and work one 24-h extended duration work shift every sixth day. Mission controllers nominally worked 24-h extended duration shifts. Supplemental lighting was provided to crewmembers and mission controllers. Participants' sleep was estimated by wrist-actigraphy recordings. Overall, results show that crewmembers and mission controllers obtained inadequate sleep and exhibited impaired cognitive function, despite countermeasure use, while working extended duration shifts. Crewmembers averaged 7.04±0.92 h (mean±SD) and 6.94±1.08 h (mean±SD) in the two workdays prior to the extended duration shifts, 1.88±0.40 h (mean±SD) during the 24-h work shift, and then slept 10.18±0.96 h (mean±SD) the day after the night shift. Although supplemental light was provided, crewmembers’ average nocturnal melatonin levels remained elevated during extended 24-h work shifts. Naps and caffeine use were reported by crewmembers during ∼86% and 45% of extended night work shifts, respectively. Even with reported use of wake-promoting countermeasures, significant impairments in cognitive function were observed. Mission controllers slept 5.63±0.95 h (mean±SD) the night prior to their extended duration work shift. On an average, 89% of night shifts included naps with mission controllers sleeping an average of 3.4±1.0 h (mean±SD) during the 24-h extended duration work shift. Mission controllers also showed impaired cognitive function during extended duration work shifts.These findings indicate that extended duration work shifts present a significant challenge to crewmembers and mission support specialists during long-duration space mission operations. Future research is needed to evaluate the efficacy of alternative work schedules and the development and implementation of more effective countermeasures will be required to maintain high levels of performance.     

Electric transfer optimization for mars sample return mission

The aim of this paper is to analyse an alternative scenario for Mars Sample Return Orbiter mission, where electric propulsion is used for Earth-Mars and Mars-Earth heliocentric cruises and for Mars orbit insertion / escape transfers, whereas chemical propulsion is used for final Mars rendezvous. The problem consists in minimizing the initial vehicle mass to obtain a specific final dry mass in reasonable time. The planetocentric phases correspond to continuous low-thrust trajectories, spiraling around Mars between a low orbit and the influence sphere altitude. The heliocentric phases consist of a succession of low-thrust and coasting arcs with specific departure and arrival conditions at the Earth. For these two types of transfer, efficient optimal control tools exist based on Pontryagin's maximum principle. Thanks to the coordination between planetocentric and heliocentric phases, the solution obtained with these two separate tools gives a good upper bound of the optimal solution in terms of propellant consumption and duration. This optimization procedure is described and finally applied to the proposed mission. The numerical results are presented and compared with the baseline chemical mission solution. The electric option could allow to decrease the spacecraft departure mass but may lead to rather long mission duration.     

Development and evaluation of bioregenerative menus for Mars habitat missions

Two 10-day menus were developed in preparation for a Mars habitat mission. The first was built on the assumption, as in previous menu development efforts for closed ecological systems, that the food system would be vegetarian, whereas the second menu introduced shelf-stable, prepackaged meat and entrée items from the current International Space Station (ISS) food system. Both menus delivered an average of 3000 cal daily but the macronutrient proportions resulted in an excess of carbohydrates and dietary fiber per mission nutritional recommendations. Generally, the individual recipes comprising both menus were deemed acceptable by internal sensory panel (average overall acceptability=7.4). The incorporation of existing ISS entrée items did not have a significant effect on the acceptability of the menus. In a final comparison, the food system upmass, or the amount of food that is shipped from the Earth, increased by 297 kg with the addition of prepackaged entrées to the menu. However, the addition of the shipped massed was counterbalanced by a 864 kg reduction in required crops. A further comparison of the crew time required for meal preparation and farming, food system power requirements, and food processing equipment mass is recommended to definitively distinguish the menus.