Evaluation of spontaneous baroreflex response after 28 days head down tilt bedrest

The spontaneous baroreflex response was evaluated during supine rest and head up tilt (60 degrees) before and immediately after a 28 day 6 degrees HDT bedrest in 6 healthy adult men (age 30-42 years). Sequences of 3 or more beats where RR-interval and systolic blood pressure changed in the same direction were used to evaluate baroreflex response slope (BRS). Prior to bedrest, the mean BRS and RR-interval were 18.0 +/- 3.9 ms/mm Hg and 926 +/- 61 ms at rest and 10.5 +/- 2.5 ms/mm Hg and 772 +/- 63 ms during the first 10 min of 60 degrees tilt. Following bedrest, these values changed to 15.6 +/- 2.7 ms/mm Hg and 780 +/- 53 ms at rest, and to 6.5 +/- 1.2 ms/mm Hg and 636 +/- 44 ms during tilt. Thus, (1) the spontaneous baroreflex can be evaluated in human subjects during experiments of orthostatic stress; (2) the baroreflex slope was reduced on going from supine to the head up tilt position; and (3) 28 days of bedrest reduced the spontaneous baroreflex slope.     

多孔隙隔热材料内压的时间响应

尝试将DSMC方法运用在隔热材料的机理研究中,对多相隔热材料的二 维简化模型分别进行了厚度在1mm、2.5mm、5mm下,不同内外压比下压力时间响应的计算分 析,旨在研究此种材料内部的压力时间响应及其影响因素。结果表明：压力响应时间随内外 压比的增加、厚度的增加都在不断增加。相对内外压比而言,厚度对响应时间的影响比较明 显,而内外压力比相同时,响应时间没有明显变化。在同一压比下,随着材料厚度的增加, 响应时间将呈现非线性增加。厚度在毫米量级时的响应时间约在几十微秒至毫秒量级,响应 时间与厚度近似呈现指数关系。〖JP〗     

煤油温度对于爆震波形成影响的实验研究

在内径为30mm的脉冲爆震发动机模型上，以煤油为燃料，以空气为氧化剂，成功地进行了两相爆震实验，获得了充分发展的脉冲爆震波。测试了在化学恰当比，不同爆震频率及燃油温度下的爆震波压力，并对其变化进行了分析。通过分析实验结果发现，在化学恰当比下，爆震频率不变时，煤油温度的升高明显促进了爆震的形成，在内径小于混合物胞格尺寸的爆震管内，可以形成充分发展的两相脉冲爆震波。     

Skylab experiment M-092: results of the first manned mission

Blood pressure at 30-sec intervals, heart rate, and percentage increase in leg volume continuously were recorded during a 25-min protocol in the M092 Inflight Lower Body Negative Pressure (LBNP) experiment carried out in the first manned Skylab mission. These data were collected during six tests on each crewman over a 5-month preflight period. The protocol consisted of a 5-min resting control period, 1 min at -8, 1 min at -16, 3 min at -30, 5 min at -40, and 5 min at -50 mm Hg LBNP. A 5-min recovery period followed. Inflight tests were performed at approximately 3-day intervals through the 28-day mission. Individual variations in cardiovascular responses to LBNP during the preflight period continued to be demonstrated in the inflight tests. Measurements of the calf indicated that a large volume of fluid was shifted out of the legs early in the flight and that a slower decrease in leg volume, presumably due to loss of muscle tissue, continued throughout the flight. Resting heart rates tended to be low early in the flight and to increase slightly as the flight progressed. Resting blood pressure varied but usually was characterized by slightly elevated systolic blood pressure, lower diastolic pressure, and higher pulse pressures than during preflight examinations. During LBNP inflight a much greater increase in leg volume occurred than in preflight tests. Large increases occurred even at the smallest levels of negative pressure, suggesting that the veins of the legs were relatively empty at the beginning of the LBNP. The greater volume of blood pooled in the legs was associated with greater increases of heart rate and diastolic pressure and larger falls of systolic and pulse pressure than seen in preflight tests. The LBNP protocol represented a greater stress inflight, and on three occasions it was necessary to stop the test early because of impending syncopal reactions. LBNP responses inflight appeared to predict the degree of postflight orthostatic intolerance. Postflight responses to LBNP during the first 48 hours were characterized by marked elevations of heart rate and instability of blood pressure. In addition, systolic and diastolic pressures were typically elevated considerably both at rest and also during stress. The time required for cardiovascular responses to return to preflight levels was much slower than in the case of Apollo crewmen.     

Droplet vaporization in supercritical pressure environments

For most liquid-fueled combustion systems the behavior of the fuel as it is introduced to the combustion zone, often by spray injection, will have a significant impact on combustion. The subsequent combustion may be affected to a considerable degree by the initial spread of the liquid, break-up of larger fuel sheets and droplets into droplets of various sizes, droplet vaporization, and diffusion of gaseous fuel. Among the many factors which affect spray break-up and droplet vaporization are the environmental conditions into which the spray is introduced. For both diesel engines and rockets the environment pressure and temperature may be above the critical pressure and temperature of the injected fuel. In a compression-ignition internal combustion engine, the environment consists primarily of air, at pressures from 20 to 100 atmospheres and temperatures ranging from 900 to 1500 K. Even higher pressures are encountered in turbocharged diesels. A typical diesel reference fuel, dodecane, has a thermodynamic critical pressure of about 17 atmospheres, and a critical temperature of 600 K. Fuel is injected into a diesel engine environment in which ambient pressures exceed the critical pressure. While droplet temperatures are subcritical at first, they may rise to the critical temperature or higher.This paper will survey current understanding of supercritical pressure droplet vaporization. Specifically, the topics covered will include: liquid phase behavior; vapor phase behavior; thermodynamic and transport properties; droplet distribution and break-up; micro-explosions; and effects of microgravity.     

Shock tube study of boundary layer instability

An experimental study of the spatio-temporal evolution of the transition in a shock-tube wall boundary-layer has been carried out with thin film heat transfer gauges placed all along the tube. The results show that the transition appears, for small initial pressures, under the form of turbulent spots which are periodically created: these spots grow and are transported roughly at a velocity slightly smaller than the inviscid flow, regressing towards the contact surface. For higher initial pressures, a continuous transitional front is created which moves at about the same velocity as the shock-wave. These results seem to explain previous and often contradictory interpretations based on quasi-punctual measurements but the fact remains that the characterization criteria of the transition in unsteady boundary layers are still to be studied.     

Effects of a simulated martian UV flux on the cyanobacterium, Chroococcidiopsis sp. 029

Dried monolayers of Chroococcidiopsis sp. 029, a desiccation-tolerant, endolithic cyanobacterium, were exposed to a simulated martian-surface UV and visible light flux, which may also approximate to the worst-case scenario for the Archean Earth. After 5 min, there was a 99% loss of cell viability, and there were no survivors after 30 min. However, this survival was approximately 10 times higher than that previously reported for Bacillus subtilis. We show that under 1 mm of rock, Chroococcidiopsis sp. could survive (and potentially grow) under the high martian UV flux if water and nutrient requirements for growth were met. In isolated cells, phycobilisomes and esterases remained intact hours after viability was lost. Esterase activity was reduced by 99% after a 1-h exposure, while 99% loss of autofluorescence required a 4-h exposure. However, cell morphology was not changed, and DNA was still detectable by 4',6-diamidino-2-phenylindole staining after an 8-h exposure (equivalent to approximately 1 day on Mars at the equator). Under 1 mm of simulant martian soil or gneiss, the effect of UV radiation could not be detected on esterase activity or autofluorescence after 4 h. These results show that under the intense martian UV flux the morphological signatures of life can persist even after viability, enzymatic activity, and pigmentation have been destroyed. Finally, the global dispersal of viable, isolated cells of even this desiccation-tolerant, ionizing-radiation-resistant microorganism on Mars is unlikely as they are killed quickly by unattenuated UV radiation when in a desiccated state. These findings have implications for the survival of diverse microbial contaminants dispersed during the course of human exploratory class missions on the surface of Mars.     

A harness for enhanced comfort and loading during treadmill exercise in space

IntroductionLocomotor and some resistance exercises in space require a gravity replacement force in order to allow 1g-like ground reaction forces to be generated. Currently bungee cords, or other loading devices, interface with the crew member through a harness with a waist belt and shoulder straps. Crew members often find the application of the required loads to be uncomfortable, particularly at the hips.MethodsAn experimental harness was built that differed from previous in-flight designs by having a wider, moldable waist belt and contoured shoulder straps with additional padding. Eight subjects ran at 100% body weight (BW) loading for a total duration of 30 min per day on 12 days over a 3-week period in simulated 0-g conditions using horizontal suspension. A 100 mm Visual Analog Scale (VAS)¹ was used to assess harness-related and lower extremity discomfort at the end of each run.ResultsThe overall rating of harness discomfort decreased from 27 mm on the 100 mm scale on day 1 to 10 mm on day 12, with significant decreases recorded for the back and hip regions as well as the overall harness.DiscussionThe experimental harness allows for repeated exposure to 30-minute bouts of 100% BW loaded simulated 0-g running with levels of discomfort less than 30 mm on a VAS scale of 0–100 mm. We believe that the use of such a harness during on-orbit exercise countermeasures may allow exercise to be performed at levels which are more effective in preventing bone and muscle loss.     

Possible adaptation to strong magnetic fields

Animal adaptation to a strong magnetic field was investigated. Mice were exposed to 30-day total-body continuous effects of a constant magnetic field (CMF) of 1.6T, and their physiological responses were assessed. Analysis of the data obtained showed that different parameters varied in a dissimilar manner. Red blood changes returned to normal in the course of the experiment. Leucocytosis and increased content of catecholamines and corticosterone of blood and adrenals persisted throughout the exposure. Changes in the spermatogenic epithelium were most distinct after the exposure. The recovery of certain parameters during the CMF exposure is indicative of adaptation of some physiological systems. The adaptation is, however, incomplete as suggested by the long persisting stress manifestation. Reticulocytopenia and spermatogenetic abnormalities found after exposure are of particular importance.     

A new application of LBNP to measure orthostatic tolerance before and after 0-g simulation (water immersion)

Lower body negative pressure (LBNP) remains an important device for the generation of orthostatic stress in the space flight environment as well as a tool to measure inflight and postflight changes in orthostatic response.

These applied levels of LBNP have typically not exceeded 50–60 mm Hg negative pressure. Information is incomplete as to the levels of absolute LBNP orthostatic tolerance, and the factors responsible for their variance. A better definition of the tolerance limits for males and females could be expected to aid the evaluation of lower levels of LBNP.

An LBNP device was built to study absolute orthostatic tolerance; additionally, another LBNP device was constructed to permit orthostatic tolerance testing directly after a controlled water immersion period.

Absolute LBNP orthostatic tolerance patterns are analyzed for a group of males and females (series I). A preliminary statement on the variations of LBNP orthostatic tolerance after limited periods of water immersion and bed rest is also provided (series II).     

Low-Cost Operation of the ORBCOMM Satellite Constellation

Financial pressures are forcing organizations to minimize operations costs. Although the easiest way to achieve this goal is simply to reduce operational requirements, often this is not possible. Therefore, automation must be employed. This paper discusses the system trade-offs that must be performed to maximize the impact of automation efforts. The discussion begins with the development of generic automation guidelines. Since many automation issues are program-specific, the paper addresses the application of these principles to operation of the ORBCOMM satellite constellation. This example demonstrates how automation can be used to produce a highly efficient satellite operations system.     

Tolerance of anhydrobiotic eggs of the Tardigrade Ramazzottius varieornatus to extreme environments

Tardigrades are tiny (less than 1?mm in length) invertebrate animals that have the potential to survive travel to other planets because of their tolerance to extreme environmental conditions by means of a dry ametabolic state called anhydrobiosis. While the tolerance of adult tardigrades to extreme environments has been reported, there are few reports on the tolerance of their eggs. We examined the ability of hydrated and anhydrobiotic eggs of the tardigrade Ramazzottius varieornatus to hatch after exposure to ionizing irradiation (helium ions), extremely low and high temperatures, and high vacuum. We previously reported that there was a similar pattern of tolerance against ionizing radiation between hydrated and anhydrobiotic adults. In contrast, anhydrobiotic eggs (50% lethal dose; 1690 Gy) were substantially more radioresistant than hydrated ones (50% lethal dose; 509 Gy). Anhydrobiotic eggs also have a broader temperature resistance compared with hydrated ones. Over 70% of the anhydrobiotic eggs treated at either -196°C or +50°C hatched successfully, but all the hydrated eggs failed to hatch. After exposure to high-vacuum conditions (5.3×10(-4) Pa to 6.2×10(-5) Pa), the hatchability of the anhydrobiotic eggs was comparable to that of untreated control eggs.     

液体推进系统高温高压动密封发展趋势分析

航天液体动力系统液体燃料的供给与调节系统的密封工作条件非常恶劣，密封压差大、温度高、线速度大、工作时间长，对密封件技术带来很大挑战。本文介绍了国内外密封技术方面的一些新技术、新工艺、新概念等关键技术的应用，探讨了密封技术长寿命、高转速、高压力、高温环境和泄漏量小（甚至零泄漏）的发展趋势，分析了高温高压动密封的难点及关键技术。     

Was Earth ever infected by martian biota? Clues from radioresistant bacteria

Here we propose that the radioresistance (tolerance to ionizing radiation) observed in several terrestrial bacteria has a martian origin. Multiple inconsistencies with the current view of radioresistance as an accidental side effect of tolerance to desiccation are discussed. Experiments carried out 25 years ago were reproduced to demonstrate that "ordinary" bacteria can develop high radioresistance ability after multiple cycles of exposure to high radiation dosages followed by cycles of recovery of the bacterial population. We argue that "natural" cycles of this kind could have taken place only on the martian surface, and we hypothesize that Mars microorganisms could have developed radioresistance in just several million years' time and, subsequently, have undergone transfer to Earth by way of martian meteorites. Our mechanism implies multiple and frequent exchanges of biota between Mars and Earth.     

Correlation of macro and micro cardiovascular function during weightlessness and simulated weightlessness

The investigation of cardiovascular function necessarily involves a consideration of the exchange of substances at the capillary. If cardiovascular function is compromised or in any way altered during exposure to zero gravity in space, then it stands to reason that microvascular function is also modified. We have shown that an increase in cardiac output similar to that reported during simulated weightlessness is associated with a doubling of the number of post-capillary venules and a reduction in the number of arterioles by 35%. If the weightlessness of space travel produces similar changes in cardiopulmonary volume and cardiac output, a reasonable expectation is that astronauts will undergo venous neovascularization. We have developed an animal model in which to correlate microvascular and systemic cardiovascular function. The microcirculatory preparation consists of a lightweight, thermo-neutral chamber implanted around intact skeletal muscle on the back of a rat. Using this technique, the performed microvasculature of the cutaneous maximus muscle may be observed in the conscious, unanesthetized animal. Microcirculatory variables which may be obtained include venular and arteriolar numbers, lengths and diameters, single vessel flow velocities, vasomotion, capillary hematocrit anastomoses and orders of branching. Systemic hemodynamic monitoring of cardiac output by electromagnetic flowmetry, and arterial and venous pressures allows correlation of macro- and microcirculatory changes at the same time, in the same animal. Observed and calculated hemodynamic variables also include pulse pressure, heart rate, stroke volume, total peripheral resistance, aortic compliance, minute work, peak aortic flow velocity and systolic time interval. In this manner, an integrated assessment of total cardiovascular function may be obtained in the same animal without the complicating influence of anesthetics.     

铁电阴极用于小功率电推力器

分析了当前小功率电推力器对零流动无推进剂阴极的需求现状。提出铁电阴极用于小功率电推进中和器的可能性。研究了厚度为0．5mm的PLZT（锆钛镧酸铅）铁电陶瓷在低电压（1．0～1．2kV）条件下的电子发射性能。实验采用脉宽为1μs的单极性正高压脉冲作为激励源。在收集极获得了脉宽为320ns～3000ns,最高峰值为34A的发射电流。在10^-4乇的真空环境中得到了非常可靠的电子发射。     

UltraFlex太阳电池阵的结构优化

以提高圆形太阳电池阵的展开过程稳定性和固有频率为优化目标，以UltraFlex太阳电池阵为模型，采用有限元软件SAMCEF对其进行结构优化。以承重梁材料、斜梁开口高度、斜梁位置、梁截面高度及厚度5种结构参数为优化变量，进行了多种工况的展开动力学仿真和模态计算。经分析发现，结构展开后期太阳毯与支撑梁拉扯会导致支撑梁剪切应力激增；梁材料、斜梁位置与支撑梁截面高度对太阳电池阵的展开过程稳定性影响较大；当梁材料为碳纤维，斜梁位置为1100 mm，梁截面高度为20 mm时，展开过程稳定性最好；斜梁位置和承重梁截面厚度对结构固有频率影响较大；当斜梁位置为900 mm或1100 mm、承重梁截面厚度从3 mm增至3.5 mm时，系统固有频率涨幅最大，由此带来的质量增加可以接受。     

甲烷喷射温度对燃烧稳定性影响规律研究

对液氧/甲烷火箭发动机燃烧稳定性进行了数值仿真研究,比较分析了甲烷喷射温度对其燃烧稳定性的影响规律.结果表明：在222 K,224 K,226 K,228 K,230 K和234 K时,发动机燃烧稳定性较好.     

基于贝叶斯稀疏重构的非均匀样本谱估计

在航空电子对抗领域,往往需要利用非均匀样本来估计信号的频谱。针对非均匀样本谱估计问题,提出了贝叶斯稀疏重构谱估计算法(BSRSE)。该算法首先将非均匀采样的谱估计表示为稀疏信号重构问题。然后利用拉普拉斯分布表示稀疏性,建立贝叶斯模型。最后通过构造加速的不动点迭代方法估计参数,从而估计信号频谱。与现有谱估计方法比较,该算法具有较高的频率分辨力、较强的噪声适应能力,且需要较少的样本数。数值仿真验证了该算法的有效性。     

Increased urinary excretion rates of serotonin and metabolites during bedrest

Astronauts are often on a voluntarily reduced energy intake during space missions, possibly caused by a metabolic or emotional stress response with involvement of the central serotonergic system (SES). We investigated 24 h urinary excretion (24 h-E) of serotonin (5-HT) and 5-hydroxyindol acidic acid as indicators of the SES in healthy males under two different normocaloric conditions: normal physical activity (NPA) and -6 degree head-down-tilt (HDT). HDT or NPA were randomly arranged with a recovery period of 6 months in between. 24 h-E of hormones varied widely among individuals. Values were higher in HDT compared to NPA. Assuming that the 24 h-E values are, beside being indicators for alterations in the number and metabolism of platelets. Also indicators of central SES, HDT condition seems to activate central SES in a higher degree compared to NPA. Therefore, changes in central SES might be involved in the mechanisms associated with space flight or microgravity, including possible maladaptations such as voluntary undernutrition.