Cancer risk above 1 Gy and the impact for space radiation protection

Analyses of the epidemiological data on the Japanese A-bomb survivors, who were exposed to γ-rays and neutrons, provide most current information on the dose–response of radiation-induced cancer. Since the dose span of main interest is usually between 0 and 1 Gy, for radiation protection purposes, the analysis of the A-bomb survivors is often focused on this range. However, estimates of cancer risk for doses larger than 1 Gy are becoming more important for long-term manned space missions. Therefore in this work, emphasis is placed on doses larger than 1 Gy with respect to radiation-induced solid cancer and leukemia mortality. The present analysis of the A-bomb survivors data was extended by including two extra high-dose categories and applying organ-averaged dose instead of the colon-weighted dose. In addition, since there are some recent indications for a high neutron dose contribution, the data were fitted separately for three different values for the relative biological effectiveness (RBE) of the neutrons (10, 35 and 100) and a variable RBE as a function of dose. The data were fitted using a linear and a linear-exponential dose–response relationship using a dose and dose-rate effectiveness factor (DDREF) of both one and two. The work presented here implies that the use of organ-averaged dose, a dose-dependent neutron RBE and the bending-over of the dose–response relationship for radiation-induced cancer could result in a reduction of radiation risk by around 50% above 1 Gy. This could impact radiation risk estimates for space crews on long-term mission above 500 days who might be exposed to doses above 1 Gy. The consequence of using a DDREF of one instead of two increases cancer risk by about 40% and would therefore balance the risk decrease described above.     

R3D-B2 – Measurement of ionizing and solar radiation in open space in the BIOPAN 5 facility outside the FOTON M2 satellite

Solar and space radiation have been monitored using the R3D-B2 radiation risks radiometer-dosimeter on board a recent space flight on the Russian satellite Foton M2 within the ESA Biopan 5 facility mounted on the outside of the satellite exposed to space conditions. The solar radiation has been assayed in four wavelength bands (UV-C, 170–280 nm, UV-B, 280–315 nm), UV-A (315–400 nm) and PAR (photosynthetic active radiation, 400–700 nm). The data show an increasing tumbling rotation of the satellite during the mission. The photodiodes do not show a cosine response to the incident light which has been corrected. After calibration of the signals using the extraterrestrial spectrum, doses have been calculated for each orbit, for each day and for the total mission as basic data for the biological material which has been exposed in parallel in the Biopan facility. Cosmic ionizing radiation has been monitored and separated in 256 deposited energy spectra, which were further used for determination of the absorbed dose rate and flux. Basic data tables were prepared to be used by other Biopan 5 experiments. The paper summarizes the results for the Earth radiation environment at the altitude (262–304 km) of the Foton M2 spacecraft. Comparisons with the predictions of NASA Earth radiation environment experimental models AE-8 and AP-8, and the PSB97 model are also presented, which calculate the fluxes of ionizing radiation from a simulation. AP-8 is a model for trapped radiation.     

Cytogenetic examination of cosmonauts for space radiation exposure estimation

Purpose

To evaluate radiation induced chromosome aberration frequency in peripheral blood lymphocytes of cosmonauts who participated in flights on Mir Orbital Station and ISS (International Space Station).

Materials and methods

Cytogenetic examination which has been performed in the period 1992–2008 included the analysis of chromosome aberrations using conventional Giemsa staining method in 202 blood samples from 48 cosmonauts who participated in flights on Mir Orbital Station and ISS.

Results

Space flights led to an increase of chromosome aberration frequency. Frequency of dicentrics plus centric rings (Dic+Rc) depend on the space flight duration and accumulated dose value. After the change of space stations (from Mir Orbital Station to ISS) the radiation load of cosmonauts based on data of cytogenetic examination decreased. Extravehicular activity also adds to chromosome aberration frequency in cosmonauts’ blood lymphocytes. Average doses after the first flight, estimated by the frequency of Dic+Rc, were 227 and 113 mGy Eq for long-term flights (LTF) and 107 and 53 mGy Eq for short-term flights (STF).

Conclusion

Cytogenetic examination of cosmonauts can be applied to assess equivalent doses.     

Human response to high-background radiation environments on Earth and in space

The main long-term objective of the space exploration program is the colonization of the planets of the Solar System. The high cosmic radiation equivalent dose rate represents an inescapable problem for the safe establishment of permanent human settlements on these planets. The unshielded equivalent dose rate on Mars ranges between 100 and 200 mSv/year, depending on the Solar cycle and altitude, and can reach values as high as 360 mSv/year on the Moon. The average annual effective dose on Earth is about 3 mSv, nearly 85% of which comes from natural background radiation, reduced to less than 1 mSv if man-made sources and the internal exposure to Rn daughters are excluded. However, some areas on Earth display anomalously high levels of background radiation, as is the case with thorium-rich monazite bearing sand deposits where values 200–400 times higher than the world average can be found. About 2% of the world’s population live above 3 km and receive a disproportionate 10% of the annual effective collective dose due to cosmic radiation, with a net contribution to effective dose by the neutron component which is 3–4 fold that at sea level. Thus far, epidemiological studies have failed to show any adverse health effects in the populations living in these terrestrial high-background radiation areas (HBRA), which provide an unique opportunity to study the health implications of an environment that, as closely as possibly achievable on Earth, resembles the chronic exposure of future space colonists to higher-than-normal levels of ionizing radiation. Chromosomal aberrations in the peripheral blood lymphocytes from the HBRA residents have been measured in several studies because chromosomal damage represents an early biomarker of cancer risk. Similar cytogenetic studies have been recently performed in a cohort of astronauts involved in single or repeated space flights over many years. The cytogenetic findings in populations exposed to high dose-rate background radiation on Earth or in space will be discussed.     

Perspective on space radiation for space flights in 2020–2040

The Sun undergoes several well known periodicities in activity, such as the Schwabe 11 year cycle, the Gleissberg 80–90 year cycle, the Suess 200–210 year cycle and the Halstatt 2200–2300 year cycle. In addition, there is evidence that the 20th century levels of solar activity are unusually high. The years 2020–2040 are expected to coincide with increased activity in human space flight beyond low Earth orbit. The solar cycles and the present level of solar activity are reviewed and their activities during the years 2020–2040 are discussed with a perspective on space radiation and the future program of space flight. It is prudent to prepare for continuing levels of high solar activity as well as for the low levels of the current deep minimum, which has corresponded to high galactic cosmic ray flux.     

Laser measurements to space debris from Graz SLR station

In order to test laser ranging possibilities to space debris objects, the Satellite Laser Ranging (SLR) Station Graz installed a frequency doubled Nd:YAG pulse laser with a 1 kHz repetition rate, a pulse width of 10 ns, and a pulse energy of 25 mJ at 532 nm (on loan from German Aerospace Center Stuttgart – DLR). We developed and built low-noise single-photon detection units to enable laser ranging to targets with inaccurate orbit predictions, and adapted our standard SLR software to include a few hundred space debris targets. With this configuration, we successfully tracked – within 13 early-evening sessions of each about 1.5 h – 85 passes of 43 different space debris targets, in distances between 600 km and up to more than 2500 km, with radar cross sections from >15 m² down to <0.3 m², and measured their distances with an average precision of about 0.7 m RMS.     

New evidence of solar variation in temperature proxies from Northern Fennoscandia

A new summer temperature proxy was built for northern Fennoscandia in AD 1000–2004 using parameters of tree growth from a large region, extending from the Swedish Scandes to the Kola Peninsula. It was found that century-scale (55–140 year) cyclicity is present in this series during the entire time interval. This periodicity is highly significant and has a bi-modal structure, i.e. it consists of two oscillation modes, 55–100 year and 100–140 year variations. A comparison of the century-long variation in the northern Fennoscandian temperature proxy with the corresponding variations in Wolf numbers and concentration of cosmogenic ¹⁰Be in glacial ice shows that a probable cause of this periodicity is the modulation of regional climate by the secular solar cycle of Gleissberg. This is in line with the results obtained previously for a more limited part of the region (Finnish Lapland: 68–70° N, 20–30° E). Thus the reality of a link between long-term changes in solar activity and climate in Fennoscandia has been confirmed. Possible mechanisms of solar influence on the lower troposphere are discussed.     

Effects of lighting and air movement on temperatures in reproductive organs of plants in a closed plant growth facility

Temperature increases in plant reproductive organs such as anthers and stigmas could cause fertility impediments and thus produce sterile seeds under artificial lighting conditions without adequately controlled environments in closed plant growth facilities. There is a possibility such a situation could occur in Bioregenerative Life Support Systems under microgravity conditions in space because there will be little natural convective or thermal mixing. This study was conducted to determine the temperature of the plant reproductive organs as affected by illumination and air movement under normal gravitational forces on the earth and to make an estimation of the temperature increase in reproductive organs in closed plant growth facilities under microgravity in space. Thermal images of reproductive organs of rice and strawberry were captured using infrared thermography at air temperatures of 10–11 °C. Compared to the air temperature, temperatures of petals, stigmas and anthers of strawberry increased by 24, 22 and 14 °C, respectively, after 5 min of lighting at an irradiance of 160 W m⁻² from incandescent lamps. Temperatures of reproductive organs and leaves of strawberry were significantly higher than those of rice. The temperatures of petals, stigmas, anthers and leaves of strawberry decreased by 13, 12, 13 and 14 °C, respectively, when the air velocity was increased from 0.1 to 1.0 ms⁻¹. These results show that air movement is necessary to reduce the temperatures of plant reproductive organs in plant growth facilities.     

Space observations of comets during solar flares: A possible explanation for comet brightness outbursts

Problems connected with mechanisms for comet brightness outbursts as well as for gamma-ray bursts remain open. Meantime, calculations show that irradiation of a certain class of comet nuclei, having high specific electric resistance, by intense fluxes of energetic protons and positively charged ions with kinetic energies more than 1 MeV/nucleon, ejected from the Sun during strong solar flares, can produce a macroscopic high-voltage electric double layer with positive charge in the subsurface zone of the nucleus, during irradiation times of the order of 10–100 h at heliocentric distances around 1–10 AU. The maximum electric energy accumulated in such layer will be restricted by the electric discharge potential of the layer material. For comet nuclei with typical radii of the order of 1–10 km the accumulated energy of such natural electric capacitor is comparable to the energy of large comet outbursts that are estimated on the basis of ground based optical observations. The impulse gamma and X-ray radiation together with optical burst from the comet nucleus during solar flares, anticipated due to high-voltage electric discharge, may serve as an indicator of realization of the processes above considered. Multi-wavelength observations of comets and pseudo-asteroids of cometary origin, having brightness correlation with solar activity, using ground based optical telescopes as well as space gamma and X-ray observatories, during strong solar flares, are very interesting for the physics of comets as well as for high energy astrophysics.     

Ionospheric reflection of the magnetic activity described by the index η

Differences in the external part of the vertical geomagnetic component point to the existence of local inhomogeneities in the magnetosphere or the ionosphere. Usually used magnetic indices are not sufficient to express the state of ionosphere, the common used global Kp index derived in the three-hour interval does not indicate much more rapidly changes appearing in ionosphere. Magnetic index η reflects ionospheric disturbances when other indices show very quiet conditions. Data of ionospheric characteristics (foE, foEs, h’E, h’F2) during 28-day long quiet day conditions (Kp = 0–2) in 2004 were analyzed. The correlations between strong local disturbances in ionosphere during very quiet days and high values of magnetic index η were found. The most sensitive to magnetic influence – ionospheric E layer data (foE characteristic) – reaches median deviations up to (+0.8 MHz and −0.8 MHz) during very low magnetic activity (Kp = 0–1). The high peaks (2–2.7) of the magnetic index η correlate in time with large local median deviations of foE. Such local deviations can suggest local inhomogeneities (vertical drifts) in the ionosphere. The correlation in space is not trivial. The strong peak of η is situated between the positive and negative deviations of foE. Additional observation is connected with correlation in time of the high η value with the negative median deviations of h’F2 (in some cases up to −90 km). The analysis was based on one-minute data recorded at each of 20 European Magnetic Observatories working in the INTERMAGNET network and from 19 ionosondes for 2004. Ionospheric data are sparse in time and in space in opposite to the magnetic data. The map of the magnetic indices can suggest the behavior of ionospheric characteristics in the areas where we have no data.     

Planetary wave coupling of the atmosphere–ionosphere system during the Northern winter of 2008/2009

This paper presents the global spatial (latitude and altitude) structure and temporal variability of the ∼23-day ionospheric zonally symmetric (s = 0) planetary wave (PW) seen in the Northern winter of 2008/2009 (October 2008–March 2009). It is shown that these ∼23-day ionospheric oscillations are forced from PWs propagating from below. The COSMIC ionospheric parameters f_oF2 and h_mF2 and electron density at fixed altitudes and the SABER temperatures were utilized in order to define the waves which are present simultaneously in the atmosphere and ionosphere. The long-period PWs from the two data sets have been extracted through the same data analysis method. The similarity between the lower thermospheric ∼23-day (s = 0) temperature PW and its ionospheric electron density response provides valuable and strong experimental evidence for confirming the paradigm of atmosphere–ionosphere coupling.     

Solar proton events recorded in the stratosphere during cosmic ray balloon observations in 1957–2008

Long-term balloon observations have been performed by the Lebedev Physical Institute since 1957 up to the present time. The observations are taken several times a week at the polar and mid latitudes and allow us to study dynamics of galactic and solar cosmic ray as well as secondary particle fluxes in the atmosphere and in the near-Earth space. Solar energetic particles (120) – mostly protons – (SEP) events with >100 MeV proton intensity above 1 cm⁻² s⁻¹ s⁻¹ were recorded during 1958–2006. Before the advent of the SEP monitoring on spacecraft these results constituted the only homogeneous series of >100 MeV SEP events. The SEP intensities and energy spectra inferred from the Lebedev Physical Institute observations are consistent with the results taken in the adjacent energy intervals by the spacecraft and neutron monitors. Joint consideration of the SEP events series recorded by balloons and by neutron monitors during solar cycles 20–23 makes it possible to restore the probable number of events in solar cycle 19, which was not properly covered by observations. Some correlation was found between duration of SEP event production in a solar cycle and sunspot cycle characteristics.     

AVS-F observations of γ-ray emission during January 20, 2005 solar flare up to 140 MeV

The solar flare of January 20, 2005 (X7.1, 06:36–07:26 UT, maximum at 07:01 UT by the GOES soft X-ray data) was the most powerful one in January 2005 series. The AVS-F apparatus onboard CORONAS-F registered γ-emission during soft X-ray rising phase of this flare in two energy ranges of 0.1–20 MeV and 2–140 MeV. The highest γ-ray energy registered during this flare was ∼140 MeV. Six spectral features were registered in energy spectrum of this solar flare: annihilation + αα (0.4–0.6 MeV), ²⁴Mg + ²⁰Ne + ²⁸Si + neutron capture (1.7–2.3 MeV), ²¹Ne + ²²Ne + ¹⁶O + ¹²С (3.2–5.0 MeV), ¹⁶O (5.3–6.9 MeV), one from neutral pions decay (25–110 MeV) and one in energy band 15–21 MeV. Four of them contain typical for solar flares lines – annihilation, nuclear de-excitation and neutron capture at ¹H. Spectral feature caused by neutral pions decay was registered during several flares too. Some spectral peculiarities in the region of 15–21 MeV were first observed in solar flare energy spectrum.     

Variation of ionospheric total electron content at crest of equatorial anomaly in China from 1997 to 2004

The periodic variation of TEC data at Xiamen station (geographic coordinate: 24.4°N, 118.1°E; geomagnetic coordinate: 13.2°N, 187.4°E) at crest of equatorial anomaly in China from 1997 to 2004 is analyzed. The characteristic of TEC association with solar activity and geomagnetic activity are also analyzed. The method of continuous wavelet, cross wavelet and wavelet coherence transform methods have been used. Analysis results show that long-term variations of TEC at Xiamen station are mainly controlled by the variations of solar activities. Several remarkable components including 128–256 days, 256–512 days and 512–1024 days exist in TEC variations. The TEC data at Xiamen station is in anti-phase with geomagnetic Dst index in semiannual time-scale, but this response only exists during high solar activity. Diurnal variation of TEC is studied for different seasons. Some features like the semiannual anomaly and winter anomaly in TEC have been reported.     

Evaluation of upper body muscle activity during cardiopulmonary resuscitation performance in simulated microgravity

Performance of efficient single-person cardiopulmonary resuscitation (CPR) is vital to maintain cardiac and cerebral perfusion during the 2–4 min it takes for deployment of advanced life support during a space mission. The aim of the present study was to investigate potential differences in upper body muscle activity during CPR performance at terrestrial gravity (+1Gz) and in simulated microgravity (μG). Muscle activity of the triceps brachii, erector spinae, rectus abdominis and pectoralis major was measured via superficial electromyography in 20 healthy male volunteers. Four sets of 30 external chest compressions (ECCs) were performed on a mannequin. Microgravity was simulated using a body suspension device and harness; the Evetts–Russomano (ER) method was adopted for CPR performance in simulated microgravity. Heart rate and perceived exertion via Borg scores were also measured. While a significantly lower depth of ECCs was observed in simulated microgravity, compared with +1Gz, it was still within the target range of 40–50 mm. There was a 7.7% decrease of the mean (±SEM) ECC depth from 48 ± 0.3 mm at +1Gz, to 44.3 ± 0.5 mm during microgravity simulation (p < 0.001). No significant difference in number or rate of compressions was found between the two conditions. Heart rate displayed a significantly larger increase during CPR in simulated microgravity than at +1Gz, the former presenting a mean (±SEM) of 23.6 ± 2.91 bpm and the latter, 76.6 ± 3.8 bpm (p < 0.001). Borg scores were 70% higher post-microgravity compressions (17 ± 1) than post +1Gz compressions (10 ± 1) (p < 0.001). Intermuscular comparisons showed the triceps brachii to have significantly lower muscle activity than each of the other three tested muscles, in both +1Gz and microgravity. As shown by greater Borg scores and heart rate increases, CPR performance in simulated microgravity is more fatiguing than at +1Gz. Nevertheless, no significant difference in muscle activity between conditions was found, a result that is favourable for astronauts, given the inevitable muscular and cardiovascular deconditioning that occurs during space travel.     

The extension of the INCL model for simulation of shielding in space

Radiation hazard for space missions is mainly due to cosmic ray protons, helium nuclei and light ions, whose energy spectrum is maximum around 1 GeV per nucleon but remains non-negligible for energies up to 15 GeV per nucleon. Nuclear reactions induced by high energy protons are often described by intranuclear cascade plus evaporation models. The attention is focused here on the Liège Intranuclear Cascade model (INCL), which has been shown to reproduce fairly well a great deal of experimental data for nucleon-induced reactions in the 200 MeV to 2 GeV range, when coupled with the ABLA evaporation-fission code. In order to extend the model to other conditions relevant for space radiation, three improvements of INCL are under development. They are reported on here. First, the reaction model has been extended to nucleon–nucleus reactions at incident energies up to 15 GeV, mainly by the inclusion of additional pion production channels in nucleon–nucleon collisions during the cascade. Second, a coalescence mechanism for the emission of light charged particles has been implemented recently. Finally, the model has been modified in order to accommodate light ions as projectiles. First results are shown and compared with illustrative experimental data. Implications for issues concerning radiation protection in space are discussed.     

Depth dose measurements with the Liulin-5 experiment inside the spherical phantom of the MATROSHKA-R project onboard the International Space Station

The Liulin-5 experiment is a part of the international project MATROSHKA-R on the Russian segment of the ISS, which uses a tissue-equivalent spherical phantom equipped with a set of radiation detectors. The objective of the MATROSHKA-R project is to provide depth dose distribution of the radiation field inside the sphere in order to get more information on the distribution of dose in a human body. Liulin-5 is a charged particle telescope using three silicon detectors. It measures time resolved energy deposition spectra, linear energy transfer (LET) spectra, particle flux, and absorbed doses of electrons, protons and heavy ions, simultaneously at three depths along the radius of the phantom. Measurements during the minimum of the solar activity in cycle 23 show that the average absorbed daily doses at 40 mm depth in the phantom are between 180 μGy/day and 220 μGy/day. The absorbed doses at 165 mm depth in the phantom decrease by a factor of 1.6–1.8 compared to the doses at 40 mm depth due to the self-shielding of the phantom from trapped protons. The average dose equivalent at 40 mm depth is 590 ± 32 μSV/day and the galactic cosmic rays (GCR) contribute at least 70% of the total dose equivalent at that depth. Shown is that due to the South Atlantic Anomaly (SAA) trapped protons asymmetry and the direction of Liulin-5 lowest shielding zone the dose rates on ascending and descending nodes in SAA are different. The data obtained are compared to data from other radiation detectors on ISS.     

Accurate orbit predictions for debris orbit manoeuvre using ground-based lasers

Orbit manoeuvre of low Earth orbiting (LEO) debris using ground-based lasers has been proposed as a cost-effective means to avoid debris collisions. This requires the orbit of the debris object to be determined and predicted accurately so that the laser beam can be locked on the debris without the loss of valuable laser operation time. This paper presents the method and results of a short-term accurate LEO (<900 km in altitude) debris orbit prediction study using sparse laser ranging data collected by the EOS Space Debris Tracking System (SDTS). A main development is the estimation of the ballistic coefficients of the LEO objects from their archived long-term two line elements (TLE). When an object is laser tracked for two passes over about 24 h, orbit prediction (OP) accuracy of 10–20 arc seconds for the next 24–48 h can be achieved – the accuracy required for laser debris manoeuvre. The improvements in debris OP accuracy are significant in other applications such as debris conjunction analyses and the realisation of daytime debris laser tracking.     

Ground-based and satellite DC-ULF electric field anomalies around Wenchuan M8.0 earthquake

The ground-based and satellite DC-ULF electric field data were analyzed around Wenchuan M8.0 earthquake on May 12, 2008 in China. The results show that ground electric field anomalies occurred at 3 stations located to the north and south of the epicenter with the amplitude of 3–100 mV/km. The change shapes and their amplitude of ground electric field anomalies are different largely due to their individual underground layer conductivity, water level and so on. The analysis of long time series illustrates that the abnormal geoelectric field started since March 2008. Onboard the DEMETER satellite, the ULF waveforms of electric field were collected and processed by wavelet transform method. The disturbances in the ionosphere were about 3–5 mV/m at a frequency band lower than 0.5 Hz. When the ground and space electric field anomalies were compared, their occurrence time and spatial distribution points are consistent with each other, including the long time anomalies from March 2008 and the short term ones 1–2 days before the Wenchuan earthquake. Finally, the coupling mechanism was discussed.     

Status of the GAMMA-400 project

The preliminary design of the new space gamma-ray telescope GAMMA-400 for the energy range 100 MeV–3 TeV is presented. The angular resolution of the instrument, 1–2° at E_γ ∼ 100 MeV and ∼0.01° at E_γ > 100 GeV, its energy resolution ∼1% at E_γ > 100 GeV, and the proton rejection factor ∼10⁶ are optimized to address a broad range of science topics, such as search for signatures of dark matter, studies of Galactic and extragalactic gamma-ray sources, Galactic and extragalactic diffuse emission, gamma-ray bursts, as well as high-precision measurements of spectra of cosmic-ray electrons, positrons, and nuclei.