Physiology, medicine, long-duration space flight and the NSBRI

The hazards of long-duration space flight are real and unacceptable. In order for humans to participate effectively in long-duration orbital missions or continue the exploration of space, we must first secure the health of the astronaut and the success of such missions by assessing in detail the biomedical risks of space flight and developing countermeasures to these hazards. Acquiring the understanding necessary for building a sound foundation for countermeasure development requires an integrated approach to research in physiology and medicine and a level of cooperative action uncommon in the biomedical sciences. The research program of the National Space Biomedical Research Institute (NSBRI) was designed to accomplish just such an integrated research goal, ameliorating or eliminating the biomedical risks of long-duration space flight and enabling safe and productive exploration of space. The fruits of these labors are not limited to the space program. We can also use the gained understanding of the effects and mechanisms of the physiological changes engendered in space and the applied preventive and rehabilitative methods developed to combat these changes to the benefit of those on Earth who are facing similar physiological and psychological difficulties. This paper will discuss the innovative approach the NSBRI has taken to integrated research management and will present some of the successes of this approach.     

The space life sciences strategy for the 21st century

In the past, space life sciences has focused on gaining an understanding of physiological tolerance to spaceflight, but, for the last 10 years, the focus has evolved to include issues relevant to extended duration missions. In the 21st century, NASA's long-term strategy for the exploration of the solar system will combine the assurance of human health and performance for long periods in space with investigations aimed at searching for traces of life on other planets and acquiring fundamental scientific knowledge of life processes. Implementation of this strategy will involve a variety of disciplines including radiation health, life support, human factors, space physiology and countermeasures, medical care, environmental health, and exobiology. It will use both ground-based and flight research opportunities such as those found in current on-going programs, on Spacelab and unmanned biosatellite flights, and during Space Station Freedom missions.     

Considerations for development of countermeasures for physiological decrements associated with long-duration space missions

Countermeasures are necessary to offset or minimize the deleterious changes in human physiology resulting from long duration space flight. Exposure to microgravity alters musculoskeletal, neurosensory, and cardiovascular systems with resulting deconditioning that may compromise crew health and performance. Maintaining health and fitness at acceptable levels is critical for preserving performance capabilities required to accomplish specific mission tasks (e.g.—extravehicular activity) and to optimize performance after landing. To enable the goals of the exploration program, NASA is developing a new suite of exercise hardware such as the improved loading device, the SchRED. This presentation will update the status of current countermeasures, correlate hardware advances with improvements in exercise countermeasures, and discuss future activities for safe and productive exploration missions.     

The future of space medicine.

In November 2000, the National Aeronautics and Space Administration (NASA) and its partners in the International Space Station (ISS) ushered in a new era of space flight: permanent human presence in low-Earth orbit. As the culmination of the last four decades of human space flight activities. the ISS focuses our attention on what we have learned to date. and what still must be learned before we can embark on future exploration endeavors. Space medicine has been a primary part of our past success in human space flight, and will continue to play a critical role in future ventures. To prepare for the day when crews may leave low-Earth orbit for long-duration exploratory missions, space medicine practitioners must develop a thorough understanding of the effects of microgravity on the human body, as well as ways to limit or prevent them. In order to gain a complete understanding and create the tools and technologies needed to enable successful exploration. space medicine will become even more of a highly collaborative discipline. Future missions will require the partnership of physicians, biomedical scientists, engineers, and mission planners. This paper will examine the future of space medicine as it relates to human space exploration: what is necessary to keep a crew alive in space, how we do it today, how we will accomplish this in the future, and how the National Aeronautics and Space Administration (NASA) plans to achieve future goals.     

Behavioral and biological effects of autonomous versus scheduled mission management in simulated space-dwelling groups

Logistical constraints during long-duration space expeditions will limit the ability of Earth-based mission control personnel to manage their astronaut crews and will thus increase the prevalence of autonomous operations. Despite this inevitability, little research exists regarding crew performance and psychosocial adaptation under such autonomous conditions. To this end, a newly-initiated study on crew management systems was conducted to assess crew performance effectiveness under rigid schedule-based management of crew activities by Mission Control versus more flexible, autonomous management of activities by the crews themselves. Nine volunteers formed three long-term crews and were extensively trained in a simulated planetary geological exploration task over the course of several months. Each crew then embarked on two separate 3–4 h missions in a counterbalanced sequence: Scheduled, in which the crews were directed by Mission Control according to a strict topographic and temporal region-searching sequence, and Autonomous, in which the well-trained crews received equivalent baseline support from Mission Control but were free to explore the planetary surface as they saw fit. Under the autonomous missions, performance in all three crews improved (more high-valued geologic samples were retrieved), subjective self-reports of negative emotional states decreased, unstructured debriefing logs contained fewer references to negative emotions and greater use of socially-referent language, and salivary cortisol output across the missions was attenuated. The present study provides evidence that crew autonomy may improve performance and help sustain if not enhance psychosocial adaptation and biobehavioral health. These controlled experimental data contribute to an emerging empirical database on crew autonomy which the international astronautics community may build upon for future research and ultimately draw upon when designing and managing missions.     

Psychology and culture during long-duration space missions

The objective of this paper is twofold: (a) to review the current knowledge of cultural, psychological, psychiatric, cognitive, interpersonal, and organizational issues that are relevant to the behavior and performance of astronaut crews and ground support personnel and (b) to make recommendations for future human space missions, including both transit and planetary surface operations involving the Moon or Mars. The focus will be on long-duration missions lasting at least six weeks, when important psychological and interpersonal factors begin to take their toll on crewmembers. This information is designed to provide guidelines for astronaut selection and training, in-flight monitoring and support, and post-flight recovery and re-adaptation.     

The physical price of a ticket into space

As a direct consequence of exposure to microgravity astronauts experience a number of physiological changes, which can have serious medical implications when they return to Earth. Most immediate and significant are the head-ward shift of body fluids and the removal of gravitational loading from bone and muscles, which lead to progressive changes in the cardiovascular and musculoskeletal systems. Cardiovascular adaptations result in an increased incidence of orthostatic intolerance (fainting) post-flight, decreased cardiac output and reduced exercise capacity. Changes in the musculoskeletal system contribute significantly to the impaired functions experienced in the post-flight period. The underlying factor producing these changes is the absence of gravity. Countermeasures, therefore, are designed primarily to simulate Earth-like movements, stresses and system interactions. Exercise is one approach that has received wide operational use and acceptance in both the US and Russian space programmes, and has enabled humans to stay relatively healthy in space for well over a year. Although it remains the most effective countermeasure currently available, significant physiological degradation still occurs. The development of other countermeasures will therefore be necessary for longer duration missions, such as the human exploration of Mars.     

Some approaches to medical support for Martian expedition

Medical support in a Martian expedition will be within the scope of crew responsibilities and maximally autonomous. Requirements to the system of diagnostics in this mission include considerable use of means and methods of visualization of the main physiological parameters, telemedicine, broad usage of biochemical analyses (including "dry" chemistry), computerized collection, measurement, analysis and storage of medical information. The countermeasure system will be based on objective methods of crew fitness and working ability evaluation, individual selection of training regimens, and intensive use of computer controlled training. Implementation of the above principles implies modernization and refinement of the countermeasures currently used by space crews of long-term missions (LTM), and increases of the assortment of active and passive training devices, among them a short-arm centrifuge. The system of medical care with the functions of prevention, clinical diagnostics and timely treatment will be autonomous, too. The general requirements to medical care during the future mission are the following: availability of conditions and means for autonomous urgent and special medical aid and treatment of the most possible states and diseases, "a hospital", and assignment to the crew of one or two doctors. To ensure independence of medical support and medical care in an expedition to Mars an automated expert system needs to be designed and constructed to control the medical situation as a whole.     

Psychological countermeasures for extended manned spaceflights

The authors examine psychological issues and countermeasures in extended space flight. Individual-oriented pre-flight countermeasures include basic psychological selection and training of astronaut candidates. Crew-oriented pre-flight countermeasures include crew composition based on psychological compatibility and psychological mission preparation. Psychological inflight support measures include those that address the emotional state and well-being of astronauts, performance efficiency, and prevention of task overload. Suggestions for an integrated approach to psychological countermeasures for extended flights are presented. Case reports examine psychological selection and training of German astronauts in preparation for the STS-55 mission.     

Human missions to Mars: new psychological challenges and research issues

Human exploratory missions to Mars represent the most exciting future vision of human space flight. With respect to the distance to travel and mission duration, these missions will provide unique psychological challenges that do not compare to any other endeavor humans ever have attempted. The present paper presents outcomes of two recent projects sponsored by the European Space Agency--Humex and Reglisse--where these challenges and risks have been analyzed in some detail, and where concepts for future research have been developed. This presentation involves three steps. At first, it will be shown that our current psychological knowledge derived from orbital spaceflight and analogue environments is not sufficient to assess the specific risks of mission into outer space. Secondly, new psychological challenges of missions to Mars will be identified with respect to three different areas: (1) individual adaptation and performance, (2) crew interactions, and (3) concept and methods of psychological countermeasures. Finally, different options and issues of preparatory psychological research will be discussed.     

NEEMO 7 undersea mission

The NEEMO 7 mission was the seventh in a series of NASA-coordinated missions utilizing the Aquarius undersea habitat in Florida as a human space mission analog. The primary research focus of this mission was to evaluate telementoring and telerobotic surgery technologies as potential means to deliver medical care to astronauts during spaceflight. The NEEMO 7 crewmembers received minimal pre-mission training to perform selected medical and surgical procedures. These procedures included: (1) use of a portable ultrasound to locate and measure abdominal organs and structures in a crewmember subject; (2) use of a portable ultrasound to insert a small needle and drain into a fluid-filled cystic cavity in a simulated patient; (3) surgical repair of two arteries in a simulated patient; (4) cystoscopy and use of a ureteral basket to remove a renal stone in a simulated patient; and (5) laparoscopic cholecystectomy in a simulated patient. During the actual mission, the crewmembers performed the procedures without or with telementoring and telerobotic assistance from experts located in Hamilton, Ontario. The results of the NEEMO 7 medical experiments demonstrated that telehealth interventions rely heavily on a robust broadband, high data rate telecommunication link; that certain interventional procedures can be performed adequately by minimally trained individuals with telementoring assistance; and that prior clinical experience does not always correlate with better procedural performance. As space missions become longer in duration and take place further from Earth, enhancement of medical care capability and expertise will be required. The kinds of medical technologies demonstrated during the NEEMO 7 mission may play a significant role in enabling the human exploration of space beyond low earth orbit, particularly to destinations such as the Moon and Mars.     

载人深空探测任务航天医学工程问题研究

航天医学工程问题关系到载人深空探测任务中的人员生存及健康。文章从人员长期生存的生命保障、变重力生理效应及防护、地外环境效应与防护、人员生理健康监测与维护、人员心理健康等方面的问题入手,分析了问题产生的原因及解决的必要性,并提出了解决思路,为后续深入开展相关关键技术的攻关提供参考。最后,以载人月球基地任务为案例,提出了生命保障、变重力防护、辐射及月尘防护、生理及心理健康监测及维护等问题的解决方案。     

High energy-density propulsion—reducing the risk to humans in planetary exploration

The potential benefits to humankind of space exploration are tremendous. Space is not only the final frontier but is also the next marketplace. The orbital space above Earth offers tremendous opportunities for both strategic assets and commercial development. The critical obstacle retarding the use of the space around the Earth is the lack of low cost access to orbit. Further out, the next giant leap for mankind will be the human exploration of Mars. Almost certainly within the next 30 years, a human crew will brave the isolation, the radiation, and the lack of gravity to walk on and explore the Red planet. Both of these missions will change the outlook and perspective of every human being on the planet. However, these missions are expensive and extremely difficult. Chemical propulsion has demonstrated an inability to achieve orbit cheaply and is a very high-risk option to accomplish the Mars mission. An alternative solution is to develop a high performance propulsion system. Nuclear propulsion has the potential to be such a system. The question will be whether humanity is willing to take on the challenge.     

Overview of the Neurolab Spacelab mission

Neurolab is a NASA Spacelab mission with multinational cooperative participation that is dedicated to research on the nervous system. The nervous systems of all animal species have evolved in a one-g environment and are functionally influenced by the presence of gravity. The absence of gravity presents a unique opportunity to gain new insights into basic neurologic functions as well as an enhanced understanding of physiological and behavioral responses mediated by the nervous system. The primary goal of Neurolab is to expand our understanding of how the nervous system develops, functions in, and adapts to microgravity space flight. Twenty-six peer reviewed investigations using human and nonhuman test subjects were assigned to one of eight science discipline teams. Individual and integrated experiments within these teams have been designed to collect a wide range of physiological and behavior data in flight as well as pre- and postflight. Information from these investigations will be applicable to enhancing the well being and performance of future long duration space travelers, will contribute to our understanding of normal and pathological functioning of the nervous system, and may be applied by the medical community to enhance the health of humans on Earth.     

Piloted operations at a near-Earth object (NEO)

In late 2006, NASA's Constellation Program sponsored a study to examine the feasibility of sending a piloted Orion spacecraft to a near-Earth object. NEOs are asteroids or comets that have perihelion distances less than or equal to 1.3 astronomical units, and can have orbits that cross that of the Earth. Therefore, the most suitable targets for the Orion Crew Exploration Vehicle (CEV) are those NEOs in heliocentric orbits similar to Earth's (i.e. low inclination and low eccentricity). One of the significant advantages of this type of mission is that it strengthens and validates the foundational infrastructure of the United States Space Exploration Policy and is highly complementary to NASA's planned lunar sortie and outpost missions circa 2020. A human expedition to a NEO would not only underline the broad utility of the Orion CEV and Ares launch systems, but would also be the first human expedition to an interplanetary body beyond the Earth–Moon system. These deep space operations will present unique challenges not present in lunar missions for the onboard crew, spacecraft systems, and mission control team. Executing several piloted NEO missions will enable NASA to gain crucial deep space operational experience, which will be necessary prerequisites for the eventual human missions to Mars.Our NEO team will present and discuss the following:

• •new mission trajectories and concepts;
• •operational command and control considerations;
• •expected science, operational, resource utilization, and impact mitigation returns; and
• •continued exploration momentum and future Mars exploration benefits.

     

Piloted operations at a near-Earth object (NEO)

In late 2006, NASA's Constellation Program sponsored a study to examine the feasibility of sending a piloted Orion spacecraft to a near-Earth object. NEOs are asteroids or comets that have perihelion distances less than or equal to 1.3 astronomical units, and can have orbits that cross that of the Earth. Therefore, the most suitable targets for the Orion Crew Exploration Vehicle (CEV) are those NEOs in heliocentric orbits similar to Earth's (i.e. low inclination and low eccentricity). One of the significant advantages of this type of mission is that it strengthens and validates the foundational infrastructure of the United States Space Exploration Policy and is highly complementary to NASA's planned lunar sortie and outpost missions circa 2020. A human expedition to a NEO would not only underline the broad utility of the Orion CEV and Ares launch systems, but would also be the first human expedition to an interplanetary body beyond the Earth–Moon system. These deep space operations will present unique challenges not present in lunar missions for the onboard crew, spacecraft systems, and mission control team. Executing several piloted NEO missions will enable NASA to gain crucial deep space operational experience, which will be necessary prerequisites for the eventual human missions to Mars.Our NEO team will present and discuss the following:

• new mission trajectories and concepts;

• operational command and control considerations;

• expected science, operational, resource utilization, and impact mitigation returns; and

• continued exploration momentum and future Mars exploration benefits.

一种图像辅助火星着陆段自主导航方法

针对未来深空探测软着陆高精度实时导航的需求,提出了一种图像辅助的自主导航方案。首先通过下降段图像与落点区域地形匹配,获得着陆器相对于落点的位置和姿态;然后基于误差Kalman模型估计着陆器的状态误差,修正惯性导航的结果;在图像信息不可用的情况下,只进行惯性递推导航;这种方案既提高了导航的精度,也能保证实时性的要求。 数值仿真验证了该方案的可行性,该方案对未来实际工程任务具有很大的参考价值。     

超导核磁共振技术在航天员生命保障中的应用前景探究

长期空间飞行会对航天员的身心健康造成一定的不利影响,开展航天员生命保障的研究是非常必要的。核磁共振技术是疾病检查诊断的重要手段,同样在航天员生命保障医疗中将发挥重要的作用。文章结合国内外相关研究进展以及航天员选拔、训练和航天员医监医保的相关知识,探究了超导核磁共振技术在航天员生命保障中的应用前景。     

A gateway for human exploration of space? The weak stability boundary

NASA's plans for future human exploration of the Solar System describe only missions to Mars. Before such missions can be initiated, much study remains to be done in technology development, mission operations and human performance. While, for example, technology validation and operational experience could be gained in the context of lunar exploration missions, a NASA lunar program is seen as a competitor to a Mars mission rather than a step towards it. The recently characterized weak stability boundary in the Earth–Moon gravitational field may provide an operational approach to all types of planetary exploration, and infrastructure developed for a gateway to the Solar System may be a programmatic solution for exploration that avoids the fractious bickering between Mars and Moon advocates. This viewpoint proposes utilizing the concept of Greater Earth to educate policy makers, opinion makers and the public about these subtle attributes of our space neighborhood.     

航天员空间活动接受辐射剂量限值的研究

空间生物学辐射效应是由空间辐射环境引起的,空间辐射环境的变化受太阳活动性影响。空间辐射水平比地表面水平高,航天员在空间所接受剂量比地面人员接受的吸收剂量高出100倍甚至更高,并且高能重离子的生物效应显著。文章简要阐述了空间辐射环境、空间辐射生物学效应与航天员的辐射剂量限值等问题。