Heavy ion-induced chromosomal damage and repair. |
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| Authors: | E H Goodwin E A Blakely |
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| Institution: | Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA. |
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| Abstract: | We have been using the "premature chromosome condensation (PCC)" technique to investigate chromosomal breakage, rejoining and misrepair induced by accelerated heavy ions. With the presentation of new Fe experiments, we now review the available PCC data to summarize our current understanding of the action of high velocity charged particles on mammalian chromosomes. Implications for the survival RBE/LET relationship are also discussed. |
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