Avoid online radiation risk: Theoretical simulation of chromosome breaks in cells exposed to heavy ions

In this study, we report an easy and quick method on simulating chromosome breaks in cells exposed to heavy charged particles. The theoretical value of chromosome break was calculated, and validated comparison with experimental value by using premature chromosome condensation technique. A good consistency was found between theoretical and experimental value. This suggested that higher relative biological effectiveness of heavy ions was closely correlated with its physical characteristics. Also, a safe approach on predicting chromosome breaks in cells exposed to heavy ions at off-line environment can be considered. Furthermore, three key factors influencing the theoretical simulation was investigated and discussed.