Polysialylation of brain gangliosides as a possible molecular mechanism for survival of Antarctic ice fish below the freezing point |
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Authors: | K Becker H Rahmann |
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Institution: | Zoological Institute, University of Stuttgart-Hohenheim, Garbenstr. 30, D-70593, Stuttgart, Germany |
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Abstract: | In order to determine possible adaptation strategies of vertebrates to extreme low-temperature environments, we compared the concentration and composition of gangliosides from the brains of eight species of Antarctic Notothenioid “ice” fishes with those of warm-adapted species and those of fishes from habitats of moderate temperature. The concentration of whole-brain gangliosides in the ice fishes was comparable with that in moderate-temperature species (between 3.36 and 4.31 mg NeuAc/g protein). The composition of brain gangliosides differed, however. In particular, the relative concentrations of polysialogangliosides (= polarity) and alkali-labile gangliosides was higher in all Antarctic species investigated than in warm-adapted fish species. This difference is considered a suitable mechanism for keeping neuronal membranes functional even below the freezing point. This interpretation is supported by additional physicochemical results with artificial monolayer membranes, which give evidence for a high thermosensitivity of ganglioside complexes in connection with calcium. |
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