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Quantification of spatial structure of human proximal tibial bone biopsies using 3D measures of complexity |
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| Authors: | Saparin Peter I Thomsen Jesper Skovhus Prohaska Steffen Zaikin Alexei Kurths Jürgen Hege Hans-Christian Gowin Wolfgang |
| Institution: | aDepartment of Radiology and Nuclear Medicine, Center of Muscle and Bone Research, Charité – University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 20, 12203 Berlin, Germany bDepartment of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Århus C, Denmark cScientific Visualization Department, Zuse Institute Berlin (ZIB), Takustr. 7, 14195 Berlin, Germany dCenter for Dynamics of Complex Systems, Institute of Physics, University of Potsdam, Am Neuen Palais 10, 14415, Potsdam, Germany |
| Abstract: | Changes in trabecular bone composition during development of osteoporosis are used as a model for bone loss in microgravity conditions during a space flight. Symbolic dynamics and measures of complexity are proposed and applied to assess quantitatively the structural composition of bone tissue from 3D data sets of human tibia bone biopsies acquired by a micro-CT scanner. In order to justify the newly proposed approach, the measures of complexity of the bone architecture were compared with the results of traditional 2D bone histomorphometry. The proposed technique is able to quantify the structural loss of the bone tissue and may help to diagnose and to monitor changes in bone structure of patients on Earth as well as of the space-flying personnel. |
| Keywords: | 3D image analysis Measures of complexity Micro-CT Osteoporosis Histomorphometry |
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