| 细胞周期停滞：AKI向CKD转变的关键点 |
| |
| 引用本文： | 李慧霞,车若琛,张爱华.细胞周期停滞：AKI向CKD转变的关键点[J].飞机设计,2021,2(1):55-63. |
| |
| 作者姓名： | 李慧霞 车若琛 张爱华 |
| |
| 作者单位： | 南京医科大学附属儿童医院,江苏 南京 210008;南京医科大学附属儿童医院,江苏 南京 210008 ；南京医科大学重点实验室,江苏 南京 210008； |
| |
| 基金项目： | 国家自然科学基金重点项目(81830020) |
| |
| 摘 要： | 急性肾损伤(Acute Kidney Injury, AKI)向慢性肾脏病(Chronic Kidney Disease, CKD)的进展过程严重影响肾脏预后及患者生存质量，是目前研究热点之一，其中细胞周期停滞是 AKI 向 CKD 进展中一个重要的致病机制。其可能通过持续增加细胞因子及炎症因子生成和释放、上皮间充质转分化、细胞器应激 / 串扰、衰老激活、管周微血管稀疏等一系列适应性不良修复过程，加速 AKI 向 CKD 转变。故调控细胞周期有望成为预防、减缓甚至阻断 AKI-CKD 进展的新的靶点机制。
|
| 关 键 词： | 细胞周期停滞 G2/M 期 急性肾损伤 慢性肾脏病 适应性不良修复 |
Cell cycle arrest: a key point of AKI-to-CKD transition |
| |
| Li Huixi,Che Ruochen,Zhang Aihua.Cell cycle arrest: a key point of AKI-to-CKD transition[J].Aircraft Design,2021,2(1):55-63. |
| |
| Authors: | Li Huixi Che Ruochen Zhang Aihua |
| |
| Abstract: | As the major threat of poor renal outcome and survival quality, the mechanism of acute kidney injury (AKI) progressing to chronic kidney disease (CKD) has aroused much attention. The cell cycle arrest, one of the major culprits, accelerates the AKI-to-CKD transition through maladaptive repair that involved overwhelming cytokines excretion and inflammation storm, epithelial-mesenchymal transition, organelles stress/crosstalk, aging activation as well as peritubular capillary rarefaction. Therefore, the cell cycle regulation can serve as a novel potential therapeutic target for the prevention, alleviation and even interruption of AKI -to- CKD transition. |
| |
| Keywords: | |
|
| 点击此处可从《飞机设计》浏览原始摘要信息 |
| 点击此处可从《飞机设计》下载免费的PDF全文 |
|
