| 糖尿病肾病进展性生物标志物的研究现状与挑战 |
| |
| 引用本文： | 冯松涛,刘必成.糖尿病肾病进展性生物标志物的研究现状与挑战[J].飞机设计,2021,2(1):28-32. |
| |
| 作者姓名： | 冯松涛 刘必成 |
| |
| 作者单位： | 东南大学附属中大医院肾脏科,东南大学肾脏病研究所,江苏 南京 210009 |
| |
| 基金项目： | 科技部国家重点研发计划(2018YFC1314000)；国家自然科学基金重点项目(8203000544)；国家自然科学基金重大国际合作项目(81720108007) |
| |
| 摘 要： | 糖尿病肾病(Diabetic Kidney Disease, DKD)是糖尿病(Diabetes Mellitus, DM)患者发生终末期肾病和死亡的主要原因。对 DKD 患者进行预后评估有助于降低疾病进展的风险及减少并发症和死亡的发生。本综述主要讨论 DKD 进展性生物标志物的现状和研究进展，包括常用的白蛋白尿和肾小球滤过率(Glomerular Filtration Rate, GFR)，以及新型生物标志物如肿瘤坏死因子受体(Tumor Necrosis Factor Alpha Receptor, TNFR)和肾小管标志物等。同时，本文还对 DKD 进展性标志物的开发和应用存在的挑战进行了讨论。
|
| 关 键 词： | 糖尿病肾病 生物标志物 预后 终末期肾病 |
Current status and challenge of biomarker studies for progressive diabetic kidney disease |
| |
| Feng Songtao,Liu Bicheng.Current status and challenge of biomarker studies for progressive diabetic kidney disease[J].Aircraft Design,2021,2(1):28-32. |
| |
| Authors: | Feng Songtao Liu Bicheng |
| |
| Institution: | Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing 210009 , Jiangsu, China |
| |
| Abstract: | Diabetic kidney disease (DKD) is the main cause of end stage renal disease and death in patients with diabetic mellitus (DM) . Prognostic assessment for patients with DKD is critical to reduce the risk of disease progression and incidence of complications or deaths. This review mainly discussed the current research status of biomarkers which might predict the progression of DKD, including the commonly used albuminuria and glomerular filtration rate (GFR) , as well as novel biomarkers like tumor necrosis factor receptor (TNFR) and renal tubular markers. Meanwhile, we discussed the potential challenges in the development and application of these biomarkers in progressive DKD. |
| |
| Keywords: | |
|
| 点击此处可从《飞机设计》浏览原始摘要信息 |
| 点击此处可从《飞机设计》下载免费的PDF全文 |
|
