淫羊藿苷促进骨折愈合作用机制的研究进展

近年来 , 国内外学者对中药淫羊藿主要有效成分淫羊藿苷加速骨折愈合的机制做了一系列研究，目前研究结果显示， 淫羊藿苷加速骨折愈合的机制主要是通过激活 Wnts、BMP、MAPK、ER 等相关信号通路促进 BMSCs、ASCs 的迁移归巢，进行成骨性分化为成骨细胞，同时促进成骨细胞的成熟、矿化以形成骨痂，并抑制破骨细胞的骨吸收活性。本文从淫羊藿苷对相关细胞以及对血管重建的作用方面对淫羊藿苷加速骨折愈合的作用机制做一回顾综述，以期为后续的研究提供参考。

The research progress on the mechanism of icariin accelerating fracture healing

In recent years, international and domestic academics have made a series of studies on the mechanism of icariin which is the main effective component of Herba Epimedii, to accelerate fracture healing. The current research results show that the mechanism of icariin accelerating fracture healing is to promote the migration and homing of BMSCs and ASCs by activating Wnts, BMP, MAPK, ER and other related signal pathways, so as to carry out osteogenic differentiation into osteoblasts. At the same time, it can promote the maturation and mineralization of osteoblasts to form callus, and inhibit the bone resorption activity of osteoclasts. This article reviews the mechanism of icariin in accelerating fracture healing from the aspects of its effects on related cells and vascular remodeling, so as to provide reference for the follow-up research.