HNIW中间体纯度测定方法

建立了测定六硝六氮杂异戊兹烷基(HNIW)两个主要中间体四乙酰基六氮杂异戊兹烷(TAIW)和四乙酰基二苄基六氮杂异戊兹烷(TADB IW)纯度的高效液相色谱法。采用二极管阵列紫外检测器检测,检测波长230 nm;中间体TAIW采用水作溶剂,DE-613反相色谱柱,甲醇流动相分离;中间体TADB IW采用冰醋酸溶解后水稀释,Symm etry-C18反相色谱柱,甲醇-水流动相分离。结果表明,两中间体分析方法标准偏差均小于1.0%,标准样品回收率均在100.0%左右,准确度和精密度较好,满足HNIW生产工艺和质量控制要求。

Determination methods for purity of intermediate products of HNIW

High performance chromatograph(HPLC) method used to determine purity of the two main intermediate products of hexanitra-hexaaza-isowurtzitane(HNIW) was established,including tetraacetyl-hexaaza-isowurtzitane(TAIW) and tetraacetyl-hexaaza-isowurtzitane(TDBIW).Photodiode array IR detector was used for detection,detection wavelength is 230 nm.TAIW is dissolved in water,separated with DE-613 column and methanol mobile phase;TADBIW is dissolved in ice acetic acid,diluted in water,separated with Symmetry-C18 column and methanol-water mobile phase.The standard deviations of intermediate products are not more than 1.0%,and the recovery ratios of the standard samples are 100.0% or so.With high precision and accuracy,the method can meet the demands of HNIW production process and quality control.