Direct radiation action of heavy ions on DNA as studied by ESR-spectroscopy. |
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| Authors: | A Schaefer J Hüttermann G Kraft |
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| Institution: | Fachrichtung Biophysik und Phys. Grundlagen der Medizin, Universit?t des Saarlandes, Homburg/Saar, Germany. |
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| Abstract: | The effects of heavy ions on the mechanisms of free radical formation in DNA-constituents as compared to low-LET irradiation are investigated by means of Electron Spin Resonance (ESR) spectroscopy. Dose-yield curves were measured at low (T < 100 K) and ambient temperatures in order to obtain the G-value, that is number of radicals formed per 100 eV absorbed energy. These G-values show a characteristic LET-dependence and are one to two orders of magnitude lower than for low-LET irradiation. Measurements on 2'Deoxycytidine at 300 K using combined heavy ion and X-ray irradiation methods suggested that this effect can be partially explained by a destruction of radicals during the irradiation. |
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