Natriuretic peptide-sensitive guanylyl cyclase expression is down-regulated in human melanoma cells at simulated weightlessness |
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| Authors: | Krassimira Ivanova Peter Eiermann Wasiliki Tsiockas Jens Hauslage Ruth Hemmersbach Rupert Gerzer |
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| Institution: | 1. Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, USA;2. Department of Chemical Engineering and Department of Bioengineering, University of California, Berkeley, California, USA;1. School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK;2. Conservation Research Institute, Dunhuang Academy, Gansu Province 736200, China |
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| Abstract: | The membrane-bound guanylyl cyclases A and B (GC-A/B), which are receptors for natriuretic peptides, are expressed in cancer cells including melanomas and may represent new anticancer targets. Here, we report down-regulation of GC-A/B expression in human metastatic melanoma cells at simulated weightlessness in comparison to 1g conditions, suggesting attenuation of metastatic potential in weightlessness. |
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