Reloading partly recovers bone mineral density and mechanical properties in hind limb unloaded rats |
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Authors: | Fan Zhao Dijie Li Yasir Arfat Zhihao Chen Zonglin Liu Yu Lin Chong Ding Yulong Sun Lifang Hu Peng Shang Airong Qian |
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Affiliation: | Key Laboratory for Space Biosciences & Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Mailbox 707, 127 West Youyi Rd., Xi?an 710072, PR China |
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Abstract: | Skeletal unloading results in decreased bone formation and bone mass. During long-term space flight, the decreased bone mass is impossible to fully recover. Therefore, it is necessary to develop the effective countermeasures to prevent spaceflight-induced bone loss. Hindlimb Unloading (HLU) simulates effects of weightlessness and is utilized extensively to examine the response of musculoskeletal systems to certain aspects of space flight. The purpose of this study is to investigate the effects of a 4-week HLU in rats and subsequent reloading on the bone mineral density (BMD) and mechanical properties of load-bearing bones. |
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Keywords: | Bone loss Hindlimb unloading Reloading BMD Mechanical properties |
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