后掠翼身交接区流动结构及参数影响研究

在水槽中利用激光片光源及荧光素钠染色液显示方法 ,研究了圆柱、机翼与平板交接区及后掠圆柱、后掠机翼变迎角情况下的干扰流场结构、特性及参数影响规律。结果表明 ,除Re数之外模型迎角、后掠角等参数对干扰区马蹄涡特性有很大影响。研究发现后掠圆柱及后掠机翼在一定条件下存在一类既不同于马蹄涡也不同于卡门涡的空间稳定发展的三维旋涡系即背涡。讨论了干扰背涡产生的机制及其与马蹄涡的相互关系。     

Effects of simulated weightlessness on the intestinal mucosal barrier of rats

This study employed a rat tail-suspension model to investigate the effects of simulated weightlessness on the intestinal mucosal barrier. Twenty-four Wistar rats were randomly divided into control (CON), 14-day tail-suspension (SUS-14d), and 21-day tail-suspension (SUS-21d) groups (n = 8 per group). Expression of occludin and zonula occludins-1 (ZO-1), proteins of the tight junction (TJ), in the intestinal mucosa was measured by immunohistochemical analysis, Western blotting, and mRNA fluorescent quantitation PCR. Plasma concentrations of diamine oxidase (DAO) and d-lactate were determined using an enzymatic spectrophotometric assay. Expression of occludin and ZO-1 was reduced in the SUS-14d and SUS-21d groups as compared to the CON group, with lowest expression observed in the SUS-21d group (P < 0.01). Examination by transmission electron microscopy (TEM) of the jejunal epithelium revealed increased intercellular space, decreased TJ and desmosome densities, and destruction of microvilli in the SUS-14d and SUS-21d groups. Plasma DAO and d-lactate concentrations in the SUS-21d group were higher than those in SUS-14d group and significantly higher than those in the CON group (P < 0.01). In all three groups, the expression of occludin and ZO-1 was found to correlate negatively with DAO (P < 0.01) and d-lactate (P < 0.01) concentrations. It is concluded that simulated weightless results in down-regulation of expression of TJ proteins in the rat intestinal mucosa. Simulated weightlessness is proposed to increase intestinal permeability through damage to the TJ.     

Tight integration of BDS-3/BDS-2/GPS/Galileo observations considering the new overlapping DISBs and its application in obstructed environments

Tight integration can enhance the model strength and positioning performance by considering the characteristic of differential inter-system bias (DISB), especially in obstructed environments. However, limited work emphasizes the comprehensive analysis of five-frequency DISBs between BDS-3 and other systems considering the receiver type, receiver configuration, and antenna type. In addition, the overlapping DISBs between BDS-3 and BDS-2 are also in great demand for further investigation since they are often regarded as one system. In this study, one DISB-float model is introduced to estimate the DISBs, and one DISB-fixed model and one DISB-free model are formulated to enhance the model strength of tight integration. Four dedicated datasets were collected to estimate the DISBs, which are also comprehensively analyzed considering the receiver type, receiver configuration, and antenna type. The results show that the DISBs between BDS-3 and other systems are rather stable over a certain period and are related to the receiver type and receiver configuration, whereas are not related to the antenna type. More interestingly, the B1I code DISB between BDS-3 and BDS-2 exhibits significant magnitude with a mean value of ?1.44 m for the baseline composed of two different receivers. In this case, the B1I code DISB must be considered and the tight integration between BDS-3 and BDS-2 considering its calibration can improve the positioning performance. Besides, the tight integration of the DISB-fixed model can significantly improve the positioning accuracy between multiple GNSS. Compared to the loose integration, the improvement of 60.6 %, 56.6 %, and 61.2 % can be obtained in the E, N, and U directions, when only two satellites are available for each system. In real obstructed environments, the tight integration of the DISB-free model can also improve the positioning performance in terms of positioning availability and accuracy, as well as the ambiguity resolution performance.