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Natriuretic peptide-sensitive guanylyl cyclase expression is down-regulated in human melanoma cells at simulated weightlessness 总被引:1,自引:0,他引:1
Krassimira Ivanova Peter Eiermann Wasiliki Tsiockas Jens Hauslage Ruth Hemmersbach Rupert Gerzer 《Acta Astronautica》2011,68(7-8):652-655
The membrane-bound guanylyl cyclases A and B (GC-A/B), which are receptors for natriuretic peptides, are expressed in cancer cells including melanomas and may represent new anticancer targets. Here, we report down-regulation of GC-A/B expression in human metastatic melanoma cells at simulated weightlessness in comparison to 1g conditions, suggesting attenuation of metastatic potential in weightlessness. 相似文献
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