DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

ADI方法求解完全跨声速非定常小扰动方程

本文修改了Whitlow的ADI格式,以便求解另一变形的完全跨声速小扰动方程。本文给出的NACA64A006和NACA0012翼型的非定常跨声速流动的计算结果与其它数值结果和实验结果的比较表明本文格式是合理的且便于实际应用的。     

高速低压差分信号（LVDS）器件应用设计方法研究

随着高速LVDS器件得到广泛应用，在高速信号使用LVDS传输时，信号传输线路问题、信号传输波形的最佳化成为非常重要的课题之一。由于印制电路板的布局布线直接影响信号传输质量，因此利用仿真对印制板分析成为设计上不可缺少的手段。有鉴于此，文章深入探讨了高速电路的设计，总结出设计技巧。     

飞机燃油油量测量及姿态误差修正方法

提出了一种基于 CAD技术的航空燃油油量实时测量方法。采用三维实体造型技术 ,建立了某飞机机翼油箱模型 ,利用油量传感器的输出值及飞机姿态信息 ,对燃油油量进行实时测量及姿态误差修正。     

High speed driving of a gain-switched laser diode with anexponential transmission line

With the increase of information capacity of an airborne system, high speed driving of laser diodes have been of interest. In order to match the low resistive LD, proposed in this paper is an exponential transmission line, which is used as preshaping to compensate the pattern effect in gain switching of laser diodes. It also will be used to overcome the effect of parasitic elements in high speed driving to improve the rise and trail edges of the output waveform. An accurate circuit model of the exponential line for the PSPICE program has been developed and simulations are conveniently carried out by employing PSPICE     

我省高职高专院校图书馆现代技术应用情况调查

目的比较与探讨不同类型高职高专图书馆现代化技术应用情况方法采用自编问卷对部分高职高专图书馆进行调查结果高职高专图书馆情况差异较大二级学院、民办学院处于前列,新高职、高专、职工大学紧随其后,挂靠学院与普通中专正在崛起。     

高速低压差分信号(LVDS)器件应用设计方法研究

随着高速LVDS器件得到广泛应用,在高速信号使用LVDS传输时,信号传输线路问题、信号传输波形的最佳化成为非常重要的课题之一。由于印制电路板的布局布线直接影响信号传输质量,因此利用仿真对印制板分析成为设计上不可缺少的手段。有鉴于此,文章深入探讨了高速电路的设计,总结出设计技巧。     

阳极氧化铝模板法制备CoPt纳米管

采用电化学直流沉积,首次在氧化铝模板中成功制备出直径为50 nm的CoPt纳米管高度有序阵列。利用透射电子显微镜(TEM)、扫描电子显微镜(SEM)、X射线衍射仪(XRD)以及振动样品磁强计(VSM)对样品的结构和磁学特性进行测试。分析表明,CoPt纳米管是以面心立方(fcc)结构存在。当外加磁场与纳米线平行时,CoPt合金纳米管的矫顽力达450 Oe,这种大面积制备的CoPt纳米管希望在超高密度信息磁存储上得到应用。     

应用泰勒中值定理研究函数的方法总结

本文讨论了应用泰勒中值定理研究函数时，如何合理选择展开点的问题，概括了以下三种方法。1、选择已知条件最多的点展开。2、选择问题所要讨论的点展开。3、选择极值点处展开。     

悬停状态下旋翼模型桨叶气弹稳定性试验研究

详细介绍了旋翼桨叶气弹稳定性试验采用的试验模型，试验设备，试验状态和试验方法。重点论述了先进旋翼的结构形式，以及简单可靠的周期变矩激振方法。试验用液压作动简对自动倾斜器的不动环激振，共进行４６种状态结果，其结果符合要求，与理论分析结果有较好的一致性。该项试验的激振方法和数据采集处理技术可直接用于直升机型号研制中的旋翼气弹稳定性试验，为进一步发展我国旋翼气弹稳定性试验技术打下了良好的基础。