Histologic effects of high energy electron and proton irradiation of rat brain detected with a silver-degeneration stain.

Application of the degeneration sensitive, cupric-silver staining method to brain sections of male Sprague-Dawley rats irradiated 4 days before sacrifice with 155 Mev protons, 2-8 Gy at 1 Gy/min (N=6) or 22-l0lGy at 20 Gy/min (N=16) or with 18.6 Mev electrons, 32-67 Gy at 20 Gy/min (N=20), doses which elicit behavioral changes (accelerod or conditioned taste aversion), resulted in a display of degeneration of astrocyte-like cell profiles which were not uniformly distributed. Plots of 'degeneration scores' (counts of profiles in 29 areas) vs. dose for the proton and electron irradiations displayed a linear dose response for protons in the range of 2-8 Gy. In the 20-100 Gy range, for both electrons and protons the points were distributed in a broad band suggesting a saturation curve. The dose range in which these astrocyte-like profiles becomes maximal corresponds well with the dose range for the X-ray eradication of a subtype of astrocytes, 'beta astrocytes'.     

On Increasing Usable MTI Filter Bandwidth by Removing Linear-Phase Constraint

It has been shown in the literature that the linear-phase constraint of finite-duration impulse-response (FIR) digital filters can, under certain circumstances, be effectively traded either for a better filter amplitude response or a reduction in the number of filter coeficients. It is shown that such a tradeoff can be exploited for moving target indicator (MTI) radar signal processors to increase the usable bandwidth for target detection. Although it is demonstrated that the increase is significant for narrowband (ground) clutter, it is negligible for wideband (weather) clutter.     

The telemedicine frontier: going the extra mile

Telemedicine has the potential to have a greater impact on the future of medicine than any other modality and will profoundly alter the medical landscape of the twenty-first century. In the most remote areas, it can bring high-quality health care where none is now available. In global health care, it can enhance and standardize the quality of medical care, including developing countries. In the realm of space flight, it can provide a lifeline to medical expertise and monitoring. Through its mobility, it can provide urgently needed health care in instances of natural disaster. However, a number of challenges exist in its coordination and implementation on a global scale, specifically in the international and remote disaster scenarios. In the area of spaceflight, telemedicine capability will remain a consultation/information ‘lifeline’, but additional onboard medical capability and expertise will become crucial complements as missions become more advanced and remote from Earth.