Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin.

Protective effects of indomethacin, a prototype prostaglandin-inhibiting agent, against early and late sequelae of radiation injury (after X-rays or gamma rays) in mice were investigated. The following tissues or organs were examined: hematopoietic tissue, esophagus, jejunum, colon, lung, hair follicles, and tissues involved in the development of radiation-induced leg contractures. In addition, the effect of indomethacin was tested against radiation-induced carcinogenesis. In all experiments, the radiation was delivered as a single dose. Indomethacin led to significant protection of hematopoietic tissue, by a factor of 1.3. There was also some protection against radiation-induced pneumonitis and against radiation-induced carcinogenesis (protection factor of 1.2). The other tissues tested showed no change in their radioresponse after being treated with indomethacin. Thus, indomethacin can act as a radioprotective agent against both early and late sequelae of radiation, but its effect is dependent on the tissue tested. This protection is smaller than that observed with WR-2721. However, indomethacin combined with WR-2721 produced a radioprotective effect greater than the radioprotection achieved by individual treatments.     

Optimization of Coverage Pattern for Regional Communications Satellite

An optimization problem of an antenna coverage pattern for a regional communications satellite when an antenna-pointing error exists is discussed. A new performance measure is introduced to evaluate the coverage pattern. This measure is defined as the statistical mean of the ratio between two areas, the full service area and the part of it covered by the antenna. The optimum coverage pattern which maximizes this measure under certain constraint is obtained. The results of numerical calculations are included to demonstrate the technique.     

Improved algorithm for estimating pulse repetition intervals

This paper presents an improved algorithm for estimating pulse repetition intervals (PRIs) of an interleaved pulse train which consists of several independent radar signals with different PRIs. The original version of this algorithm is a complex-valued autocorrelation-like integral, which leads to a kind of PRI spectrum wherein the locations of the spectral peaks indicate the PRI values. The original algorithm, however, has a serious drawback in that it is vulnerable to timing jitter (PRI jitter). We analyze the cause of this vulnerability and propose an improved algorithm using overlapped PRI bins which have shifting time origins. The improved algorithm has proven to be quite effective in obtaining the PRI spectrum for jittered pulse trains, which enables detection of mean PRIs by thresholding