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1.
Gabrion J Herbute S Oliver J Maurel D Davet J Clavel B Gharib C Fareh J Fagette S Nguyen B 《Acta Astronautica》1995,36(8-12):439-448
Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity. 相似文献
2.
Charged-particle mutagenesis II. Mutagenic effects of high energy charged particles in normal human fibroblasts. 总被引:1,自引:0,他引:1
D J Chen K Tsuboi T Nguyen T C Yang 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1994,14(10):347-354
The biological effects of high LET charged particles are a subject of great concern with regard to the prediction of radiation risk in space. In this report, mutagenic effects of high LET charged particles are quantitatively measured using primary cultures of human skin fibroblasts, and the spectrum of induced mutations are analyzed. The LET of the charged particles ranged from 25 KeV/micrometer to 975 KeV/micrometer with particle energy (on the cells) between 94-603 MeV/u. The X-chromosome linked hypoxanthine guanine phosphoribosyl transferase (hprt) locus was used as the target gene. Exposure to these high LET charged particles resulted in exponential survival curves; whereas, mutation induction was fitted by a linear model. The Relative Biological Effect (RBE) for cell-killing ranged from 3.73 to 1.25, while that for mutant induction ranged from 5.74 to 0.48. Maximum RBE values were obtained at the LET of 150 keV/micrometer. The inactivation cross-section (alpha i) and the action cross-section for mutant induction (alpha m) ranged from 2.2 to 92.0 micrometer2 and 0.09 to 5.56 x 10(-3) micrometer2, respectively. The maximum values were obtained by 56Fe with an LET of 200 keV/micrometer. The mutagenicity (alpha m/alpha i) ranged from 2.05 to 7.99 x 10(-5) with the maximum value at 150 keV/micrometer. Furthermore, molecular analysis of mutants induced by charged particles indicates that higher LET beams are more likely to cause larger deletions in the hprt locus. 相似文献
3.
V. V. Kalegaev W. O. Barinova I. N. Myagkova V. E. Eremeev D. A. Parunakyan M. D. Nguyen O. G. Barinov 《Cosmic Research》2018,56(1):32-37
An empirical model of the high-latitude boundary of the outer Earth’s radiation belt (ERB) has been presented, which is based on the measurement data of electron fluxes on the polar low-orbit CORONAS-Photon, Meteor-M1, and Meteor-M2 satellites. The boundary was determined by a sharp decrease to the background level of the flux of trapped electrons with energies of 100 or 200 keV in the polar part of the profile of the outer radiation belt. A numerical algorithm has been implemented to determine the time moment, when the fastest flux changes are recorded. The primary search was carried out, first, on 30 s averaged data, then repeated on data with a higher resolution. A functional dependence was obtained in order to approximate the obtained set of intersections of the boundary by elliptical curve. The empirical model constructed using the CORONAS-Photon measurement data in the epoch of anomalously low geomagnetic activity reflects the longitude structure of the high-latitude boundary of the outer radiation belt associated with the internal Earth’s magnetic field (MF), as well as its dependence on the universal time. Based on the data of intersections of the high-latitude boundary of the outer ERB (OERB) in the epoch of 2014–2016, the latitudinal shift of the boundary to the equator dependent on geomagnetic activity has been determined, as well as the nightside shift of the boundary due to the diurnal rotation of the Earth. 相似文献
4.
J. B. Blake P. A. Carranza S. G. Claudepierre J. H. Clemmons W. R. Crain Jr. Y. Dotan J. F. Fennell F. H. Fuentes R. M. Galvan J. S. George M. G. Henderson M. Lalic A. Y. Lin M. D. Looper D. J. Mabry J. E. Mazur B. McCarthy C. Q. Nguyen T. P. O’Brien M. A. Perez M. T. Redding J. L. Roeder D. J. Salvaggio G. A. Sorensen H. E. Spence S. Yi M. P. Zakrzewski 《Space Science Reviews》2013,179(1-4):383-421
This paper describes the Magnetic Electron Ion Spectrometer (MagEIS) instruments aboard the RBSP spacecraft from an instrumentation and engineering point of view. There are four magnetic spectrometers aboard each of the two spacecraft, one low-energy unit (20–240 keV), two medium-energy units (80–1200 keV), and a high-energy unit (800–4800 keV). The high unit also contains a proton telescope (55 keV–20 MeV). The magnetic spectrometers focus electrons within a selected energy pass band upon a focal plane of several silicon detectors where pulse-height analysis is used to determine if the energy of the incident electron is appropriate for the electron momentum selected by the magnet. Thus each event is a two-parameter analysis, an approach leading to a greatly reduced background. The physics of these instruments are described in detail followed by the engineering implementation. The data outputs are described, and examples of the calibration results and early flight data presented. 相似文献
5.
J. B. Blake B. H. Mauk D. N. Baker P. Carranza J. H. Clemmons J. Craft W. R. Crain A. Crew Y. Dotan J. F. Fennell R. H. Friedel L. M. Friesen F. Fuentes R. Galvan C. Ibscher A. Jaynes N. Katz M. Lalic A. Y. Lin D. M. Mabry T. Nguyen C. Pancratz M. Redding G. D. Reeves S. Smith H. E. Spence J. Westlake 《Space Science Reviews》2016,199(1-4):309-329
6.
This paper gives a complete analysis of the problem of aeroassisted return from a high Earth orbit to a low Earth orbit with plane change. A discussion of pure propulsive maneuver leads to the necessary change for improvement of the fuel consumption by inserting in the middle of the trajectory an atmospheric phase to obtain all or part of the required plane change. The variational problem is reduced to a parametric optimization problem by using the known results in optimal impulsive transfer and solving the atmospheric turning problem for storage and use in the optimization process. The coupling effect between space maneuver and atmospheric maneuver is discussed. Depending on the values of the plane change i, the ratios of the radii, between the orbits and between the low orbit and the atmosphere, and the maximum lift-to-drag ratio E1 of the vehicle, the optimal maneuver can be pure propulsive or aeroassisted. For aeroassisted maneuver, the optimal mode can be parabolic, which requires only drag capability of the vehicle, or elliptic. In the elliptic mode, it can be by one-impulse for deorbit and one or two-impulse in postatmospheric flight, or by two-impulse for deorbit with only one impulse for final circularization. It is shown that whenever an impulse is applied, a plane change is made. The necessary conditions for the optimal split of the plane changes are derived and mechanized in a program routine for obtaining the solution. 相似文献
7.
Jeng-Shing Chern Ching-Yew Yang Nguyen X. Vinh John M. Hanson 《Acta Astronautica》1985,12(10):819-829
With increasing frequency in shuttle operation, it is of interest to have more than one or two landing fields within the boundary of the reachable area of the reentry vehicle. This boundary, called the footprint, depends on the aerodynamic characteristics of the vehicle and is severely restricted by the deceleration and heating constraints imposed upon the atmospheric reentry trajectory. This paper gives a general assessment of the footprint as a function of various deceleration and heating constraints. The difficulties in the computation of the three-dimensional reentry trajectories with optimal modulation in both the angle-of-attack and the bank angle are alleviated by the following devices: (a) nondimensionalizing of the equations of motion and use of the density as the altitude variable; (b) use of the classical integrals of the motion; (c) transformation of the adjoint variables into physical variables; and (d) spherical rotation of the coordinates. 相似文献
8.
Stark L. Tendick F. Kim W. Anderson R. Hisey M. Mills B. Matsunaga K. An Nguyen Ramos C. Tyler M. Zahalak G. Amick M. Baker B. Brown N. Brown T. Chang J. Jyh-Horng Chen Chik J. Cohen D. Cox D. Dubey J. Ellis K. Engdahl E. Frederickson C. Halamka J. Hauser R. Jacobs J. Lee C. Lee D. Liu A. Ninomiya R. Rudolph J. Schafer S. Schendel E. So G. Takeda M. Tam L. Thompson M. Wood E. Woodruff T. 《IEEE transactions on aerospace and electronic systems》1988,24(5):542-551
With major emphasis on simulation, a university laboratory telerobotics facility permits problems to be approached by groups of graduate students. Helmet-mounded displays provide realism; the slaving of the display to the human operator's viewpoint gives a sense of `telepresence' that may be useful for prolonged tasks. Using top-down 3-D model control of distant images allows distant images to be reduced to a few parameters to update the model used for display to the human operator in a preview model to circumvent, in part, the communication delay. Also, the model can be used as a format for supervisory control and permit short-term local autonomous operations. Image processing algorithms can be made simpler and faster without trying to construct sensible images from the bottom. Control studies of telerobots lead to preferential manual control modes and, in this university environment, to basic paradigms for human motion and thence, perhaps, to redesign of robotic control, trajectory path planning, and rehabilitation prosthetics. Speculation as to future industrial drives for this telerobotic field suggests efficient roles for government agencies such as NASA 相似文献
9.
Chae Kyung Sim Huynh Anh Nguyen Le Soojong Pak Hye-In Lee Wonseok Kang Moo-Young Chun Ueejeong Jeong In-Soo Yuk Kang-Min Kim Chan Park Michael D. Pavel Daniel T. Jaffe 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2014
We present a Python-based data reduction pipeline package (PLP) for the Immersion GRating INfrared Spectrograph (IGRINS), an instrument that covers the complete H- and K-bands in one exposure with a spectral resolving power of 40,000. The reduction steps carried out by the PLP include flat-fielding, background removal, order extraction, distortion correction, wavelength calibration, and telluric correction using spectra of A type standard stars. As the spectrograph has no moving parts, the PLP automatically reduces the data using predefined functions for the processes of order extraction, distortion correction, and wavelength calibration. Before the telluric correction of the target spectra, the intrinsic hydrogen absorption features of the standard A star are removed with a Gaussian fitting algorithm. The final result is the flux of the target as a function of wavelength. Users can customize the predefined functions for the extraction of the spectrum from the echellogram and adjust the parameters for the fitting functions for the spectra of celestial objects, using “fine-tuning” options, as necessary. Presently, the PLP produces the best results for point-source targets. 相似文献
10.
V.V Benghin V.M Petrov Yu.V Ivanov V.A Shurshakov S.B Kozlova V.D Nguyen J.F Bottollier M Siegrist 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,18(12):167-170
The estimation of radiation quality factor in space flights is a serious problem of space dosimetry. The solution of this problem is based on LET-spectra measurements. The “NAUSICAA”-device installed on the “MIR” station has a detector with a large geometric factor, that gives the possibility of measuring LET-spectra with sufficient statistic in relatively short time interval and hence the corresponding Q. LET-spectra are accumulated through 24 hour periods and equivalent dose (H), absorbed dose (D), quality factor and flux (F) are measured every 10 minutes. The obtained data permit the estimate of the diurnal Q and Q in South Atlantic Anomaly. These values vary in the range of 1.4 – 2.2. The analysis of these values including their comparison with the calculated results is given in this paper. 相似文献