Main medical results of extended flights on space station Mir in 1986-1990

During 1986-1990 seven prime spacecrews (16 cosmonauts) have flown on-board the Mir orbital complex. The longest space mission duration was 366 days The principal objectives of the medical tasks were the maintenance of good health and performance of the spacecrews and conducting medical research programs which included study of the cardiovascular, motor, endocrine, blood, immune, and metabolic systems. Results obtained point to the ability of humans to readily adapt to a year-long stay in space and maintain good health and performance. Readaptation had a similar course as after other previous long-term space flights of up to 8 months in duration. Primary body system changes were not qualitatively different from findings after flights aboard the Salyut 6 and 7 space stations. In this case, during and after an 11-12 month flight, body system alterations were even less severe which was a result of adequate countermeasure use, their systematic and creative employment and maintenance of required environments to support life and work in space.     

Human adaptation to simulated gravitational fields

We present the resuIts of manned studies in which test subjects were exposed to simulated zero g (water immersion or head-down tilt at -6 degrees) and head-to-feet acceleration. The findings give evidence that humans have different individual tolerances to an acceleration of +3 Gz after exposure to zero g, whether simulated by immersion or by head-down tilt. The paper discusses the role of functional relationship between water balance and cardiac output in the establishment of adaptive reactions to simulated zero g.     

Medical problems of manned space flights onboard orbital stations.

Medical aspects of crew safety and life support as well as biomedical investigations form part and parcel of the preparation and conduct of manned space programs. The list of biomedical problems related to these programs is very long. The present paper concentrates on some of them.     

Human adaptation to simulated gravitational fields

We present the results of manned studies in which test subjects were exposed to simulated zero $\text{g}$ (water immersion or head-down tilt at ?6°) and head-to-feet acceleration. The findings give evidence that humans have different individual tolerances to an acceleration of +3 G_z after exposure to zero $\text{g}$, whether simulated by immersion or by head-down tilt. The paper discusses the functional relationship between water balance and cardiac output in the establishment of adaptive reactions to simulated zero $\text{g}$.     

Central and regional hemodynamics in prolonged space flights.

This paper presents the results of measuring central and regional (head, forearm, calf) hemodynamics at rest and during provocative tests by the method of tetrapolar rheography in the course of Salyut-6-Soyuz and Salyut-7-Soyuz missions. The measurements were carried out during short-term (19 man-flights of 7 days in duration) and long-term (21 man-flights of 65-237 days in duration) manned missions. At rest, stroke volume (SV) and cardiac output (CO) as well as heart rate (HR) decreased insignificantly (in short-term flights) or remained essentially unchanged (in long-term flights). In prolonged flights CO increased significantly in response to exercise tests due to an increase in HR and the lack of changes in SV. After exercise tests SV and CO decreased as compared to the preflight level. During lower body negative pressure (LBNP) tests HR and CO were slightly higher than preflight. Changes in regional hemodynamics included a distinct decrease of pulse blood filling (PBF) of the calf, a reduction of the tone of large vessels of the calf and small vessels of the forearm. Head examination (in the region of the internal carotid artery) showed a decrease of PBF of the left hemisphere (during flight months 2-8) and a distinct decline of the tone of small vessels, mainly, in the right hemisphere. During LBNP tests the tone of pre- and postcapillary vessels of the brain returned to normal while PBF of the right and left hemisphere vessels declined. It has been shown that regional circulation variations depend on the area examined and are induced by a rearrangement of total hemodynamics of the human body in microgravity. This paper reviews the data concerning changes in central and regional circulation of men in space flights of different duration.