Global and local geospace modeling in ISTP

The objective of the University of Maryland ISTP theory project is the development of the analytical and computational tools, which, combined with the data collected by the space and ground-based ISTP sensors, will lead to the construction of the first causal and predictive global geospace model. To attain this objective a research project composed of four complementary parts is conducted. First the global interaction of the solar wind-magnetosphe re system is studied using three-dimensional MHD simulations. Appropriate results of these simulations are made available to other ISTP investigators through the Central Data Handling Facility (CDHF) in a format suitable for comparison with the observations from the ISTP spacecrafts and ground instruments. Second, simulations of local processes are performed using a variety of non-MHD codes (hybrid, particle and multifluid) to study critical magnetospheric boundary layers, such as the magnetopause and the magnetotail. Third, a strong analytic effort using recently developed methods of nonlinear dynamics is conducted, to provide a complementary semi-empirical understanding of the nonlinear response of the magnetosphere and its parts to the solar wind input. The fourth part will be conducted during and following the data retrieval and its objective is to utilize the data base in conjunction with the above models to produce the next generation of global and local magnetospheric models. Special emphasis is paid to the development of advanced visualization packages that allow for interactive real time comparison of the experimental and computational data. Examples of the computational tools and of the ongoing investigations are presented.     

Electrophysiological, histochemical, and hormonal adaptation of rat muscle after prolonged hindlimb suspension

The perspective of long-duration flights for future exploration, imply more research in the field of human adaptation. Previous studies in rat muscles hindlimb suspension (HLS), indicated muscle atrophy and a change of fibre composition from slow-to-fast twitch types. However, the contractile responses to long-term unloading is still unclear. Fifteen adult Wistar rats were studied in 45 and 70 days of muscle unweighting and soleus (SOL) muscle as well as extensor digitorum longus (EDL) were prepared for electrophysiological recordings (single, twitch, tetanic contraction and fatigue) and histochemical stainings. The loss of muscle mass observed was greater in the soleus muscle. The analysis of electrophysiological properties of both EDL and SOL showed significant main effects of group, of number of unweighting days and fatigue properties. Single contraction for soleus muscle remained unchanged but there was statistically significant difference for tetanic contraction and fatigue. Fatigue index showed a decrease for the control rats, but increase for the HLS rats. According to the histochemical findings there was a shift from oxidative to glycolytic metabolism during HLS. The data suggested that muscles atrophied, but they presented an adaptation pattern, while their endurance in fatigue was decreased.