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Tesshu Ikawa Amu Kawaguchi Takahiro Okabe Tadashi Ninomiya Yuko Nakamichi Midori Nakamura Shunsuke Uehara Hiroaki Nakamura Nobuyuki Udagawa Naoyuki Takahashi Hiroaki Nakamura Shigeyuki Wakitani 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2011
The effects of gravity on bone metabolism are unclear, and little has been reported about the effects of hypergravity on the mature skeleton. Since low gravity has been shown to decrease bone volume, we hypothesized that hypergravity increases bone volume. To clarify this hypothesis, adult female rats were ovariectomized and exposed to hypergravity (2.9G) using a centrifugation system. The rats were killed 28 days after the start of loading, and the distal femoral metaphysis of the rats was studied. Bone architecture was assessed by micro-computed tomography (micro-CT) and bone mineral density was measured using peripheral quantitative CT (pQCT). Hypergravity increased the trabecular bone volume of ovariectomized rats. Histomorphometric analyses revealed that hypergravity suppressed both bone formation and resorption and increased bone volume in ovariectomized rats. 相似文献
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