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Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. 总被引:3,自引:0,他引:3
T K Hei Y L Zhao D Roy C Q Piao G Calaf E J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):411-419
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process. 相似文献
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Hwu S.U. Loh Y.C. Dobbins J.A. Kroll Q.D. Sham C.C. 《Aerospace and Electronic Systems Magazine, IEEE》2005,20(10):9-14
Computational investigations and experimental measurements were performed to evaluate the Space Shuttle UHF communication system performance for payload bay antenna at the proposed new location. To insure adequate communication coverage at relocated new location, the link margin for the Extravehicular Activity (EVA) astronauts and between Space Shuttle Orbiter and International Space Station (SSO-ISS) during rendezvous were analyzed. The multipath effects from the vehicle structures surrounding the antenna were investigated. The Radio Frequency (RF) electromagnetic radiation to the Orbiter Docking System (ODS) pyrotechnics was also analyzed to ensure the EMC/EMI compliances. 相似文献
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本文首先分析了空军航空修理企业的管理特点,然后详细论述了空军航空修理物资管理信息系统的设计原则、网络方案、总体结构及软件设计方法。 相似文献
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本文介绍一种新型磁粉探伤机周向电流的单片计算机控制器,文中详细介绍控制器的控制原理,结构,控制程序。该控制器对周向电流采用闭环控制,直接设定磁化电流,可保证电流稳定,电流设定值和实际电流值相差小于10%,控制器还具有了出错检测,自动退磁功能。 相似文献
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根据星群分离控制的一般要求,本文研究了卫星群的相对运动方程,分析了其相对运动特性,在合理的近似假设下对Hill方程为出发点,研究了各卫星相对距离限制下的分离控制方法。最后对精确方程与近似方程的仿真比较,表明所设计的健康控制方法是可行的,其结果是可信的。 相似文献
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通过嵌入光纤对芳纶/五氧复合材料板及环氧树脂浇注体的固化进行初步研究,结果表明,光纤嵌入法能准确监测出浇注体及芳纶/环氧复合材料的瞬时固化情况。 相似文献
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M. Kawaji R.Q. Liang M. Nasr-Esfahany S. Simic-Stefani S. Yoda 《Acta Astronautica》2006,58(12):622-632
The effects of small vibrations on Marangoni convection were investigated experimentally using a liquid bridge of 5 cSt silicone oil with a disk diameter of 7.0 mm, and an aspect ratio close to 0.5. Experiments were performed to determine the critical temperature difference data for no vibration case and with small vibrations applied. The experimental results have shown that the effect of small vibrations on the onset of oscillatory flow is small since the critical temperature difference data for different aspect ratios were not affected by the vibrations. To clarify the surface oscillation phenomena induced by external vibrations, a 3-D numerical simulation model was also developed using a level set algorithm to predict the surface oscillations of isothermal silicone oil bridges. By subjecting the liquid bridge to small vibrations, the surface oscillation characteristics were predicted numerically, and the numerical results compared well with the predictions of an analytical model proposed previously. Furthermore, the effect of small vibrations on the surface vibration amplitude of the liquid bridge is also discussed. 相似文献
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