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1.
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. 总被引:3,自引:0,他引:3
T K Hei Y L Zhao D Roy C Q Piao G Calaf E J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):411-419
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process. 相似文献
2.
Hwu S.U. Loh Y.C. Dobbins J.A. Kroll Q.D. Sham C.C. 《Aerospace and Electronic Systems Magazine, IEEE》2005,20(10):9-14
Computational investigations and experimental measurements were performed to evaluate the Space Shuttle UHF communication system performance for payload bay antenna at the proposed new location. To insure adequate communication coverage at relocated new location, the link margin for the Extravehicular Activity (EVA) astronauts and between Space Shuttle Orbiter and International Space Station (SSO-ISS) during rendezvous were analyzed. The multipath effects from the vehicle structures surrounding the antenna were investigated. The Radio Frequency (RF) electromagnetic radiation to the Orbiter Docking System (ODS) pyrotechnics was also analyzed to ensure the EMC/EMI compliances. 相似文献
3.
M. Kawaji R.Q. Liang M. Nasr-Esfahany S. Simic-Stefani S. Yoda 《Acta Astronautica》2006,58(12):622-632
The effects of small vibrations on Marangoni convection were investigated experimentally using a liquid bridge of 5 cSt silicone oil with a disk diameter of 7.0 mm, and an aspect ratio close to 0.5. Experiments were performed to determine the critical temperature difference data for no vibration case and with small vibrations applied. The experimental results have shown that the effect of small vibrations on the onset of oscillatory flow is small since the critical temperature difference data for different aspect ratios were not affected by the vibrations. To clarify the surface oscillation phenomena induced by external vibrations, a 3-D numerical simulation model was also developed using a level set algorithm to predict the surface oscillations of isothermal silicone oil bridges. By subjecting the liquid bridge to small vibrations, the surface oscillation characteristics were predicted numerically, and the numerical results compared well with the predictions of an analytical model proposed previously. Furthermore, the effect of small vibrations on the surface vibration amplitude of the liquid bridge is also discussed. 相似文献
4.
Chao-Song Huang J.C. Foster K. Yumoto J.L. Chau O. Veliz 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2005,36(12):2407-2412
It is well known that the solar wind can significantly affect high-latitude ionospheric dynamics. However, the effects of the solar wind on the middle- and low-latitude ionosphere are much less studied. In this paper, we report observations that large perturbations in the middle- and low-latitude ionosphere are well correlated with solar wind variations. In one event, a significant (20–30%) decrease of the midlatitude ionospheric electron density over a large latitudinal range was related to a sudden drop in the solar wind pressure and a northward turning of the interplanetary magnetic field, and the density decrease became larger at lower latitudes. In another event, periodic perturbations in the dayside equatorial ionospheric E × B drift and electrojet were closely associated with variations in the interplanetary electric field. Since the solar wind is always changing with time, it can be a very important and common source of ionospheric perturbations at middle- and low-latitudes. The relationship between solar wind variations and significant ionospheric perturbations has important applications in space weather. 相似文献
5.
Lee C.Q. Liu R. Batarseh I. 《IEEE transactions on aerospace and electronic systems》1989,25(6):844-847
It is shown that by using a proper transformation of state variables, the third-order system of the parallel resonant converter (PRC) with LLC -type commutation can be analyzed by means of a two-dimensional state-plane diagram. A set of characteristic curves which can be used for the converter design is derived from the analysis. It is shown from these curves that the converter possesses more desirable features than the conventional PRC 相似文献
6.
Analysis based on the state-plane diagram is given for series resonant converters operating in the frequency range 0.5 ? fs/fo ? 1.0. When the voltages and currents in the converter are normalized, design parameters take on special geometric meanings in the normalized state diagram. Examples of converter design using graphical methods are given for the cases of ? and ? control. Control characteristics of the converter operating in the continuous conduction mode are derived. The concept of the energy reflection coefficient is introduced as a measure of power transfer efficiency in the converter design. 相似文献
7.
V. Yurchyshyn Q. Hu R.P. Lepping B.J. Lynch J. Krall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2007,40(12):1821-1826
Coronal mass ejections (CMEs) observed near the Sun via LASCO coronographic imaging are the most important solar drivers of geomagnetic storms. ICMEs, their interplanetary, near-Earth counterparts, can be detected in situ, for example, by the Wind and ACE spacecraft. An ICME usually exhibits a complex structure that very often includes a magnetic cloud (MC). They can be commonly modelled as magnetic flux ropes and there is observational evidence to expect that the orientation of a halo CME elongation corresponds to the orientation of the flux rope. In this study, we compare orientations of elongated CME halos and the corresponding MCs, measured by Wind and ACE spacecraft. We characterize the MC structures by using the Grad–Shafranov reconstruction technique and three MC fitting methods to obtain their axis directions. The CME tilt angles and MC fitted axis angles were compared without taking into account handedness of the underlying flux rope field and the polarity of its axial field. We report that for about 64% of CME–MC events, we found a good correspondence between the orientation angles implying that for the majority of interplanetary ejecta their orientations do not change significantly (less than 45 deg rotation) while travelling from the Sun to the near-Earth environment. 相似文献
8.
Q. Wang G. Xu S. Petrovic U. Schaefer U. Meyer T. Xu 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2011
A regional tropospheric model can be constructed using surveys from GPS ground networks. Using this model the tropospheric delays of a kinematic station within the region can be interpolated. However, such a model is generally not suitable for an airborne platform high above the ground networks. In this paper, a method of constructing a regional tropospheric model for airborne GPS applications is described. First, the kinematic station in the air is projected onto the ground. Then the tropospheric delays at projected point are interpolated from those of the ground networks. Finally, the tropospheric delays at projected point are extended upward to the airborne platform using pressure and temperature gradients and humidity exponential function. For validation of this method, the data of airborne campaign carried out by BKG in cooperation with GFZ and BGR 2008 in the northern Alps are used. The results show that GPS kinematic positioning precision in height component can be improved using this method. 相似文献
9.
昆虫(果蝇)悬停飞行中,翅膀按照特定的拍动方式往复运动,产生非定常高升力维持身体的平衡.研究昆虫高升力机理,需要探索拍动翼运动引发的三维空间非定常流场的特性,尤其是三维空间非定常涡的发展变化过程.本文将氢气泡流动显示技术应用于动态模型实验,定性的观察拍动翼前缘涡(LEV)的发展破裂过程.并利用数字体视粒子图像测速,DSPIV(Digital Steroscopic Particle Image Velocimetry)技术,测得了拍动翼运动瞬时相位和相位平均的三维空间流场信息(速度向量场、截面涡量场、空间涡量场,以及三维空间流线),揭示了拍动翼展向流动的存在,并结合定性和定量方法多角度说明了前缘涡沿展向发展到破裂的流动结构,并说明了侧缘涡与前缘涡的相互影响.测量结果表明:在雷诺数960的情况下,拍动翼运动至相位时,翼面上前缘涡在距翼根约60%展长的位置发生破裂;翼根至破裂点之间,展向流动稳定,指向翼梢;破裂点以后,展向流改变方向,指向翼根. 相似文献
10.
Q. Liu Z. Wu M. Zhu W.Q. Xu 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2014
The increase of balloon applications makes it necessary for a comprehensive understanding of the thermal and dynamic performance of scientific balloons. This paper proposed a novel numerical model to investigate the thermal and dynamic characteristics of scientific balloon in both ascending and floating conditions. The novel model consists of a dynamic model and thermal model, the dynamic model was solved numerically by a computer program developed with Matlab/Simulink to calculate the velocity and trajectory, the thermal model was solved by the Fluent program to find out the balloon film temperature distribution and inner Helium gas velocity and temperature field. These models were verified by comparing the numerical results with experimental data. Then the thermal and dynamic behavior of a scientific balloon in a real environment were simulated and discussed in details. 相似文献