DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

Heliospheric and Interstellar Phenomena Deduced From Pickup ion Observations

Pickup ions, created by ionization of slow moving atoms and molecules well inside the heliosphere, provide us with a new tool to probe remote regions in and beyond the heliosphere and to study injection and acceleration processes in the solar wind. Comprehensive and continuous measurements of H, He, C, N, O, Ne and other pickup ions, especially with the Solar Wind Ion Composition Spectrometer (SWICS) on both Ulysses and ACE, have given us a wealth of data that have been used to infer chemical and physical properties of the local interstellar cloud. With SWICS on Ulysses we discovered a new population of pickup ions, produced from atomic and molecular sources deep inside the heliosphere. The velocity distributions and composition of these “inner source” pickup ions are distinctly different from those of interstellar pickup ions, showing effects of strong adiabatic cooling, and a composition resembling that of the solar wind. Strong cooling indicates that the source of these pickup ions lies close to the Sun. The similarity of composition of inner source heavy ions to that of the solar wind implies that the dominant production mechanism for these pickup ions involves the absorption and re-emission of solar wind from interplanetary dust grains. While interstellar pickup ions are the seed population of the main Anomalous Cosmic Rays (ACRs), inner source pickup ions may be an important source of the rarer ACRs such as C, Mg, Si, S, and Fe. We present new results and review previous work with an emphasis on characteristics of the local interstellar cloud and properties of the inner source. This revised version was published online in August 2006 with corrections to the Cover Date.     

Developing countries and remote sensing: how intergovernmental factors impede progress

Developing countries lag significantly behind more advanced nations in the local adoption and application of satellite remote sensing technology. Narrowing this gap through appropriate international cooperation is, however, often constrained by national interests and priorities. The paper presents an overview of several of these inter-governmental constraints using as its main basis the outcomes of recent regional and international conferences hosted by the United Nations. Future enhancement of international cooperation in remote sensing will occur best within settings where both developing and technologically advanced countries are sensitive and responsive to each other's concerns.     

The applications of lower power satellites for direct television broadcasting

The use of 12 GHz satellites for TV broadcasting directly to individual homes and small communities has been the subject of analysis and design study by groups in many countries. Implementation of the concept has been slow to follow because of the high satellite transmitter powers of from 100 to 450 W that have usually been determined to be necessary. Accumulated experience in Canada with 12 GHz operation and the evolution of technology are leading to changes in the concept of direct broadcasting such that lower power satellites may be capable of meeting the requirements.

Hermes, the Canadian/U.S. 12/14 GHz Communications Technology Satellite, has been in use for over 3 years in a program of experiments and measurements. This program has included an extensive six month experiment in direct broadcasting to 7 small communities. Experience with Hermes has shown that the signal strength is stable over long periods of time and that in Canada, significant precipitation attenuation at 12 GHz is of relatively short duration and typically occurs only during certain seasons. Operation with low propagation margins is feasible if some picture degradation and some outages at these times are acceptable. The frequency and duration of occurrence of outages can be controlled by the Earth station G/T which is cost sensitive. An individual may choose to use a low cost system with a small antenna and accept a degraded picture and outages at some times. A small community may choose to pay more for a larger antenna and lower noise receiver to achieve better performance.

Developments in technology are reducing the noise figure of mass-producible receivers from more than 6 dB to as low as 4 dB. Another technology contribution is the use of reduced bandwidth and other signal processing techniques in low-cost receivers. While use of such techniques may introduce distortions that would be unacceptable in rebroadcasting systems, there is little impact for individual and community reception. Use of both technologies reduce the required satellite EIRP or ground terminal G/T.

A field trial was begun in April 1979 to test these concepts for use in television program delivery. One hundred Earth stations capable of being tuned across a 500 MHz band and having antennas with diameters of either 1.2 m or 1.8 m are being installed for a test in Canada to receive TV signals from the 20 W transponders of ANIK-B (peak EIRP of 51 dBw) on an experimental basis. The acceptability of the video signals and the technical performance of the low-cost terminals in the bands of non-technical users are being evaluated.

The paper will summarize the concept of TV broadcasting with lower power satellites and describe the results to date of the ANIK-B field trials.     

大型复合材料结构优化设计方法研究

建立了适合于大型复合材料结构的优化设计方法，该方法在复合材料结构有限元分析的基础上对复合材料结构进行优化设计。在建立有限元模型时应用了区域划分技术，然后对结构分两级进行优化：第一级是对结构的铺层角度进行优化。第二级对结构的铺层厚度进行优化。最后，以工字梁结构为例，进行了算法验证。     

基于粒子滤波的被动多基站跟踪算法

针对被动多基站跟踪的实际应用，提出了基于粒子滤波的被动多基站跟踪方法。该方法首先利用两个基站的观测数据融合目标位置，并用第三个基站的观测数据对目标位置进行检验，消除了错误融合位置；然后，推导了被动多基站粒子滤波模型，并根据被动多基站跟踪的特点，提出了顺序重抽样方法，有效地解决了被动多基站跟踪中的高度非线性、非高斯的影响；最后，给出了算法的性能仿真比较。仿真结果表明提出的方法性能明显优于其他跟踪方法（如PMHT、IMM-PDA）。     

S波段超小型调频发射机

介绍Ｓ波段超小型调频发动机方案的选择，电路设计，结构安排，并对该发射机的稳定性和质量进行了分析，该发射机已通过机载环境条件试验和地面接收机的对接试验，并已通过鉴定，具有９０年代国外同类产品的水平。     

计算机辅助任意多边形排料

 本文描述了一种计算机辅助排料的算法。它能自动处理二维不规则形状物体的排料。排料的处理过程分为两个阶段。现介绍的为第一阶段的算法。计算实例表明,该方法可以明显减少计算量。并具有原材料利用率高的特点。 飞机蒙皮等钣金件的下料就涉及到大量的排料问题,在整张的金属板材上排成所需要的零件形状。     

起落架落震试验的数字模拟方法

 <正> 在计算飞机起飞、着陆和滑行等地面运动的静、动态载荷时,除了需要飞机结构和气动参数外,起落架减震器的性能参数更占有重要地位。而这些性能参数中尤以决定油液阻尼力的流最系数为重要。长期以来,国内主要靠查手册、凭经验确定这个系数,如果能较准确地确定流量系数,对载荷计算是很有意义的事。     

SCR技术制备A2017半固态材料及其触变性能的研究

单辊搅拌技术 (SCRShearing/CoolingRollProcess)技术制备的A2 0 17半固态材料比常规铸造坯组织优良 ;SCR技术制备的A2 0 17半固态材料在 5 30～ 5 70℃范围内 ,可以进行触变成形 ;半固态成形平均屈服强度比热加工时的屈服强度低 10MPa ;A2 0 17半固态材料触变过程分为四个阶段 ,稳定触变阶段A2 0 17半固态材料的触变性能稳定 ,半固态加工时容许的最大加工变形范围为 6 4 %～ 72 %。