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Sterken Veerle J. Baalmann Lennart R. Draine Bruce T. Godenko Egor Herbst Konstantin Hsu Hsiang-Wen Hunziker Silvan Izmodenov Vladislav Lallement Rosine Slavin Jonathan D. 《Space Science Reviews》2022,218(8):1-15
Space Science Reviews - The ESA Swarm mission, launched on 22 November 2013, consists of three spacecraft each equipped with a Micro Advanced Stellar Compass ( $\mu $ ASC) from the Technical... 相似文献
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Katrin Paulsen Svantje Tauber Nadine Goelz Dana Michaela Simmet Stephanie Engeli Maria Birlem Claudia Dumrese Anissja Karer Sandra Hunziker Josefine Biskup Shalimar Konopasek Durie Suh Eva Hürlimann Christoph Signer Anna Wang Chen Sang Karl-Heinrich Grote Fengyuan Zhuang Oliver Ullrich 《Acta Astronautica》2014
During spaceflight the immune system is one of the most affected systems of the human body. During the SIMBOX (Science in Microgravity Box) mission on Shenzhou-8, we investigated microgravity-associated long-term alterations in macrophageal cells, the most important effector cells of the immune system. We analyzed the effect of long-term microgravity on the cytoskeleton and immunologically relevant surface molecules. Human U937 cells were differentiated into a macrophageal phenotype and exposed to microgravity or 1g on a reference centrifuge on-orbit for 5 days. After on-orbit fixation, the samples were analyzed with immunocytochemical staining and confocal microscopy after landing. The unmanned Shenzhou-8 spacecraft was launched on board a Long March 2F (CZ-2F) rocket from the Jiuquan Satellite Launch Center (JSLC) and landed after a 17-day-mission. We found a severely disturbed actin cytoskeleton, disorganized tubulin and distinctly reduced expression of CD18, CD36 and MHC-II after the 5 days in microgravity. The disturbed cytoskeleton, the loss of surface receptors for bacteria recognition, the activation of T lymphocytes, the loss of an important scavenger receptor and of antigen-presenting molecules could represent a dysfunctional macrophage phenotype. This phenotype in microgravity would be not capable of migrating or recognizing and attacking pathogens, and it would no longer activate the specific immune system, which could be investigated in functional assays. Obviously, the results have to be interpreted with caution as the model system has some limitations and due to numerous technical and biological restrictions (e.g. 23 °C and no CO2 supply during in-flight incubation). All parameter were carefully pre-tested on ground. Therefore, the experiment could be adapted to the experimental conditions available on Shenzhou-8. 相似文献
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