Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1

Loss of function of DNA repair genes has been implicated in the development of many types of cancer. In the last several years, heterozygosity leading to haploinsufficiency for proteins involved in DNA repair was shown to play a role in genomic instability and carcinogenesis after DNA damage is induced, for example by ionizing radiation. Since the effect of heterozygosity for one gene is relatively small, we hypothesize that predisposition to cancer could be a result of the additive effect of heterozygosity for two or more genes critical to pathways that control DNA damage signaling, repair or apoptosis. We investigated the role of heterozygosity for Atm, Rad9 and Brca1 on cell oncogenic transformation and cell survival induced by 1 GeV/n⁵⁶Fe ions. Our results show that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival rates and are more sensitive to transformation by high energy iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins. Since mutations or polymorphisms for similar genes exist in a small percentage of the human population, we have identified a radiosensitive sub-population. This finding has several implications. First, the existence of a radiosensitive sub-population may distort the shape of the dose–response relationship. Second, it would not be ethical to put exceptionally radiosensitive individuals into a setting where they may potentially be exposed to substantial doses of radiation.     

T cell regulation in microgravity – The current knowledge from in vitro experiments conducted in space,parabolic flights and ground-based facilities

Dating back to the Apollo and Skylab missions, it has been reported that astronauts suffered from bacterial and viral infections during space flight or after returning to Earth. Blood analyses revealed strongly reduced capability of human lymphocytes to become active upon mitogenic stimulation. Since then, a large number of in vitro studies on human immune cells have been conducted in space, in parabolic flights, and in ground-based facilities. It became obvious that microgravity affects cell morphology and important cellular functions. Observed changes include cell proliferation, the cytoskeleton, signal transduction and gene expression. This review gives an overview of the current knowledge of T cell regulation under altered gravity conditions obtained by in vitro studies with special emphasis on the cell culture conditions used. We propose that future in vitro experiments should follow rigorous standardized cell culture conditions, which allows better comparison of the results obtained in different flight- and ground-based experiment platforms.     

飞机燃油系统地面模拟试验干扰的产生和处理

分析燃油地面模拟试验台测控系统在调试过程中模拟量输出信号出现大幅度波动的原因,介绍其处理过程及实际效果,指出在试验中应采取的措施。     

河北省计算机一级考试上机操作题考点总结与分析

河北省计算机一级考试是面向省内普通高校在校学生的计算机等级考试，是用人单位进行计算机操作水平认定的重要标准，在高校中备受重视。本论文首先分析了河北省计算机一级考试的特点，然后总结分析了2006-2008年度考试操作题的考点分布及变化趋势。最后提出了正确备考的建议和策略。     

Upwards migration phenomenon on molten lunar regolith: New challenges and prospects for ISRU

As part of our research on the feasibility of producing commodities from lunar regolith by thermal-driven processes with minimal terrestrial precursors we need to characterize, reproduce, and understand thermophysical properties of the molten regolith still unforeseen under the lunar vacuum conditions at a scalable sample size. Two unanticipated phenomena, apparently caused by lunar melt’s surface tension under vacuum, have been revealed in our research work, vacuum void formation and upwards migration. In this paper we present our findings and thinkable explanation on the upwards migration phenomenon experimentally observed and consistently replicated as JSC-1A lunar regolith simulant melted at high vacuum. Upwards migration of molten lunar regolith will make future lunar ISRU’s melting processes both challenging as molten bulk material would migrate upwards along the container’s walls, and also promising on new opportunities for alternative ISRU’s sustainable processes as regolith’s upwards migration takes place in uniformed thin-film pattern. Among the potential ISRU’s processes that might use controlled thermal thin-film-based migration without the necessity of terrestrial precursors are production of feedstock for 3D printing, fractional separation of regolith’s component’s (O₂, metals, and alloys) via pyrolysis, film coating, purification of valuables solid crystals including silicon, and fabrication of key elements for microfluidic, and MEMS devices. Thermal upwards migration phenomenon on JSC-1A’s melt is formulated and explained by the authors as due to thermal Marangoni effect (also known as thermo-capillarity) in which temperature gradients within the melt’s bulk and along the crucible’s wall yield the surface tension large enough to supersede the gravitational force and yield the experimentally observed upwards thin-film migration. As far as the authors know, upwards thermal migration of molten JSC-1A (or other lunar simulant regolith) under vacuum has not been reported in the literature. A thermal mathematical model accounting for thermal Marangoni effect on molten JSC-1A agrees with what experimentally was observed, the formation of the meniscus on the melt-wall surface interface along with an incipient upwards migration in thin-film pattern along the crucible wall that, according to the model, experiences large temperature gradient, an important factor to trigger the thermal Marangoni effect along with the fact that surface tension of the molten lunar regolith material is temperature dependent.     

基于小波变换的卫星阻力系数分析

以不同弧长解算天宫一号空间实验室连续55天（d） GPS轨道数据得到卫星阻力系数Cd 序列,并对同期的太阳辐射通量 f 10.7 和地磁活动指数 ap,Ap序列高、低频多层小波分解。空间环境参量和Cd 序列各层信号滑动相关性的统计分析结果表明小波分解的阻力系数序列与对应的 f 10.7 ,Ap 序列整体具有很好的滞后相关性,验证了通过 f 10.7 ,Ap 预报 Cd 的可行性。对不同回归模型和回归分析样本序列长度n分析Cd预报值残差表明：采用f 10.7 一元回归模型,并取n20 d时, Cd 预报结果最优。另外,NRLMSIS-00模型在350km高度的中低纬度区域,地磁活动上升相响应过度,而下降相则响应不足;太阳辐射通量上升相响应适度,下降相响应过度。最后对应用前景进行总结,该方法对提高航天器轨道预报精度具有重要参考价值。     

“实践九号”A卫星光学遥感图像杂散光噪声去除

杂散光是影响卫星光学遥感图像像质的重要因素,严重时会在图像上形成明暗的杂散光条纹噪声,降低图像的对比度和清晰度。文章针对“实践九号”A（SJ-9A）卫星光学遥感图像存在的杂散光噪声现象,设计了一种基于成像载荷焦面入射杂散光空间分布特征的遥感图像杂散光条纹噪声去除方法,通过测量杂散光在推扫遥感图像上的空间分布特征,建立杂散光分布特征模型,采用分块自适应算法进行杂散光噪声滤波,消除SJ-9A遥感图像上随时空变化的杂散光条纹噪声。杂散光噪声去除后图像整体色调均匀,无条带噪声,满足CCD/TDI-CCD推扫遥感图像辐射校正精度（广义噪声）优于5%的指标要求。     

基于时间误差补偿的HJ-1C卫星几何定位改进

利用距离多普勒算法对 HJ-1C（“环境一号”C）卫星图像进行定位,其初始定位精度为1100~1400m,不能很好地满足实际应用的需要。进一步分析后发现,HJ-1C卫星图像几何定位误差主要分布在方位向,通过对影响HJ-1C卫星几何定位精度的因素进行分析,得出合成孔径雷达（Synthetic Aperture Radar, SAR）时间误差是影响几何定位的关键因素,因此文章提出通过时间误差补偿提高HJ-1C卫星几何定位精度。该方法首先计算SAR时间误差,然后对SAR载荷时间进行补偿,最后利用距离多普勒算法进行定位,并对HJ-1C卫星图像进行了验证。结果表明,HJ-1C卫星定位精度提高到300m左右,得到了有效的改进。     

高声强声场模拟装置设计与声试验1/3倍频程控制技术研究

为了提高混响室声场模拟能力,北京卫星环境工程研究所自研一套高声强声场模拟试验设备。文章介绍了该设备的行波管发声系统设计和消声降噪处理过程——行波终端设计以及声试验控制仪器的原理。经过调试试验验证,测量结果满足声压级165 d B行波声场的要求,行波管试验段性能良好,达到167.9 d B,消声道出口噪声能够满足环境模拟需求。     

Computations of unsteady transonic flow over airfoil at low Reynolds number

Transonic flow over a thin airfoil at low Reynolds number was studied numerically by directly solving two-dimensional full Navier-Stokes equations through 5th order weighted essentially non-oscillatory(WENO) scheme without using any turbulence model.A series of distinguished unsteady phenomena for a thin 2-D transonic airfoil flow were presented.Due to continuous adverse pressure gradient in the subsonic flow downstream of the sonic line, the unsteady separated boundary layer with main vortex and secondary vortex was developed at the rear of the airfoil.At the trailing edge,the vortex-shedding was characterized by periodical connection of the main vortex and secondary vortex on the other side of the airfoil.The unsteady separation and vortex-shedding occurred with the same period.On the airfoil surface,the average pulse pressure related to the unsteady supersonic region was obviously smaller than that related to the vortex-shedding at the trailing edge.With the attack angle increasing from 0° to 2°, the frequency of vortex-shedding decreases about 4.2%.At last, the turbulence intensity and many second-order statistics in the wake region were investigated.